Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation.

KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We invest...
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Autor*in:	Cristina Berastegui [verfasserIn] Susana Gómez-Ollés [verfasserIn] Alberto Mendoza-Valderrey [verfasserIn] Thais Pereira-Veiga [verfasserIn] Mario Culebras [verfasserIn] Victor Monforte [verfasserIn] Berta Saez [verfasserIn] Manuel López-Meseguer [verfasserIn] Helena Sintes-Permanyer [verfasserIn] Victoria Ruiz de Miguel [verfasserIn] Carlos Bravo [verfasserIn] Judit Sacanell [verfasserIn] María-Antonia Ramon [verfasserIn] Laura Romero [verfasserIn] María Deu [verfasserIn] Antonio Román [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 15(2020), 1, p e0226488
Übergeordnetes Werk:	volume:15 ; year:2020 ; number:1, p e0226488

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0226488

Katalog-ID:	DOAJ054536049

Internformat


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520			\|a KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.
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Indexfelder

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allfields	10.1371/journal.pone.0226488 doi (DE-627)DOAJ054536049 (DE-599)DOAJa4c6ffe37e664cf7a70ce747cac3c9d8 DE-627 ger DE-627 rakwb eng Cristina Berastegui verfasserin aut Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients. Medicine R Science Q Susana Gómez-Ollés verfasserin aut Alberto Mendoza-Valderrey verfasserin aut Thais Pereira-Veiga verfasserin aut Mario Culebras verfasserin aut Victor Monforte verfasserin aut Berta Saez verfasserin aut Manuel López-Meseguer verfasserin aut Helena Sintes-Permanyer verfasserin aut Victoria Ruiz de Miguel verfasserin aut Carlos Bravo verfasserin aut Judit Sacanell verfasserin aut María-Antonia Ramon verfasserin aut Laura Romero verfasserin aut María Deu verfasserin aut Antonio Román verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 15(2020), 1, p e0226488 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:15 year:2020 number:1, p e0226488 https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/article/a4c6ffe37e664cf7a70ce747cac3c9d8 kostenfrei https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1, p e0226488
spelling	10.1371/journal.pone.0226488 doi (DE-627)DOAJ054536049 (DE-599)DOAJa4c6ffe37e664cf7a70ce747cac3c9d8 DE-627 ger DE-627 rakwb eng Cristina Berastegui verfasserin aut Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients. Medicine R Science Q Susana Gómez-Ollés verfasserin aut Alberto Mendoza-Valderrey verfasserin aut Thais Pereira-Veiga verfasserin aut Mario Culebras verfasserin aut Victor Monforte verfasserin aut Berta Saez verfasserin aut Manuel López-Meseguer verfasserin aut Helena Sintes-Permanyer verfasserin aut Victoria Ruiz de Miguel verfasserin aut Carlos Bravo verfasserin aut Judit Sacanell verfasserin aut María-Antonia Ramon verfasserin aut Laura Romero verfasserin aut María Deu verfasserin aut Antonio Román verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 15(2020), 1, p e0226488 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:15 year:2020 number:1, p e0226488 https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/article/a4c6ffe37e664cf7a70ce747cac3c9d8 kostenfrei https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1, p e0226488
allfields_unstemmed	10.1371/journal.pone.0226488 doi (DE-627)DOAJ054536049 (DE-599)DOAJa4c6ffe37e664cf7a70ce747cac3c9d8 DE-627 ger DE-627 rakwb eng Cristina Berastegui verfasserin aut Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients. Medicine R Science Q Susana Gómez-Ollés verfasserin aut Alberto Mendoza-Valderrey verfasserin aut Thais Pereira-Veiga verfasserin aut Mario Culebras verfasserin aut Victor Monforte verfasserin aut Berta Saez verfasserin aut Manuel López-Meseguer verfasserin aut Helena Sintes-Permanyer verfasserin aut Victoria Ruiz de Miguel verfasserin aut Carlos Bravo verfasserin aut Judit Sacanell verfasserin aut María-Antonia Ramon verfasserin aut Laura Romero verfasserin aut María Deu verfasserin aut Antonio Román verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 15(2020), 1, p e0226488 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:15 year:2020 number:1, p e0226488 https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/article/a4c6ffe37e664cf7a70ce747cac3c9d8 kostenfrei https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1, p e0226488
allfieldsGer	10.1371/journal.pone.0226488 doi (DE-627)DOAJ054536049 (DE-599)DOAJa4c6ffe37e664cf7a70ce747cac3c9d8 DE-627 ger DE-627 rakwb eng Cristina Berastegui verfasserin aut Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients. Medicine R Science Q Susana Gómez-Ollés verfasserin aut Alberto Mendoza-Valderrey verfasserin aut Thais Pereira-Veiga verfasserin aut Mario Culebras verfasserin aut Victor Monforte verfasserin aut Berta Saez verfasserin aut Manuel López-Meseguer verfasserin aut Helena Sintes-Permanyer verfasserin aut Victoria Ruiz de Miguel verfasserin aut Carlos Bravo verfasserin aut Judit Sacanell verfasserin aut María-Antonia Ramon verfasserin aut Laura Romero verfasserin aut María Deu verfasserin aut Antonio Román verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 15(2020), 1, p e0226488 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:15 year:2020 number:1, p e0226488 https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/article/a4c6ffe37e664cf7a70ce747cac3c9d8 kostenfrei https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1, p e0226488
allfieldsSound	10.1371/journal.pone.0226488 doi (DE-627)DOAJ054536049 (DE-599)DOAJa4c6ffe37e664cf7a70ce747cac3c9d8 DE-627 ger DE-627 rakwb eng Cristina Berastegui verfasserin aut Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation. 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients. Medicine R Science Q Susana Gómez-Ollés verfasserin aut Alberto Mendoza-Valderrey verfasserin aut Thais Pereira-Veiga verfasserin aut Mario Culebras verfasserin aut Victor Monforte verfasserin aut Berta Saez verfasserin aut Manuel López-Meseguer verfasserin aut Helena Sintes-Permanyer verfasserin aut Victoria Ruiz de Miguel verfasserin aut Carlos Bravo verfasserin aut Judit Sacanell verfasserin aut María-Antonia Ramon verfasserin aut Laura Romero verfasserin aut María Deu verfasserin aut Antonio Román verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 15(2020), 1, p e0226488 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:15 year:2020 number:1, p e0226488 https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/article/a4c6ffe37e664cf7a70ce747cac3c9d8 kostenfrei https://doi.org/10.1371/journal.pone.0226488 kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2020 1, p e0226488
language	English
source	In PLoS ONE 15(2020), 1, p e0226488 volume:15 year:2020 number:1, p e0226488
sourceStr	In PLoS ONE 15(2020), 1, p e0226488 volume:15 year:2020 number:1, p e0226488
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
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container_title	PLoS ONE
authorswithroles_txt_mv	Cristina Berastegui @@aut@@ Susana Gómez-Ollés @@aut@@ Alberto Mendoza-Valderrey @@aut@@ Thais Pereira-Veiga @@aut@@ Mario Culebras @@aut@@ Victor Monforte @@aut@@ Berta Saez @@aut@@ Manuel López-Meseguer @@aut@@ Helena Sintes-Permanyer @@aut@@ Victoria Ruiz de Miguel @@aut@@ Carlos Bravo @@aut@@ Judit Sacanell @@aut@@ María-Antonia Ramon @@aut@@ Laura Romero @@aut@@ María Deu @@aut@@ Antonio Román @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ054536049
language_de	englisch
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author	Cristina Berastegui
spellingShingle	Cristina Berastegui misc Medicine misc R misc Science misc Q Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation.
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topic_title	Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation
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title	Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation.
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title_full	Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation
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author_browse	Cristina Berastegui Susana Gómez-Ollés Alberto Mendoza-Valderrey Thais Pereira-Veiga Mario Culebras Victor Monforte Berta Saez Manuel López-Meseguer Helena Sintes-Permanyer Victoria Ruiz de Miguel Carlos Bravo Judit Sacanell María-Antonia Ramon Laura Romero María Deu Antonio Román
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title_sort	use of serum kl-6 level for detecting patients with restrictive allograft syndrome after lung transplantation
title_auth	Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation.
abstract	KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.
abstractGer	KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.
abstract_unstemmed	KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.
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title_short	Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation.
url	https://doi.org/10.1371/journal.pone.0226488 https://doaj.org/article/a4c6ffe37e664cf7a70ce747cac3c9d8 https://doaj.org/toc/1932-6203
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Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation.

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