Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study

Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shreyas H Gupte [verfasserIn] Rinku D Kalra [verfasserIn] Thomson M Dcruz [verfasserIn] Sahil Kamble [verfasserIn] Ranjana S Patnaik [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	additives adrenaline clonidine hemodynamic variables local anesthetics

Übergeordnetes Werk:	In: Contemporary Clinical Dentistry - Wolters Kluwer Medknow Publications, 2010, 12(2021), 3, Seite 308-312
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:3 ; pages:308-312

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/ccd.ccd_665_20

Katalog-ID:	DOAJ054801249

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520			\|a Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline
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allfields	10.4103/ccd.ccd_665_20 doi (DE-627)DOAJ054801249 (DE-599)DOAJ57084b8d06a94ef7a6a805d1caaa9bc7 DE-627 ger DE-627 rakwb eng RK1-715 Shreyas H Gupte verfasserin aut Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline additives adrenaline clonidine hemodynamic variables local anesthetics Dentistry Rinku D Kalra verfasserin aut Thomson M Dcruz verfasserin aut Sahil Kamble verfasserin aut Ranjana S Patnaik verfasserin aut In Contemporary Clinical Dentistry Wolters Kluwer Medknow Publications, 2010 12(2021), 3, Seite 308-312 (DE-627)64057355X (DE-600)2582352-8 09762361 nnns volume:12 year:2021 number:3 pages:308-312 https://doi.org/10.4103/ccd.ccd_665_20 kostenfrei https://doaj.org/article/57084b8d06a94ef7a6a805d1caaa9bc7 kostenfrei http://www.contempclindent.org/article.asp?issn=0976-237X;year=2021;volume=12;issue=3;spage=308;epage=312;aulast=Gupte kostenfrei https://doaj.org/toc/0976-237X Journal toc kostenfrei https://doaj.org/toc/0976-2361 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 3 308-312
spelling	10.4103/ccd.ccd_665_20 doi (DE-627)DOAJ054801249 (DE-599)DOAJ57084b8d06a94ef7a6a805d1caaa9bc7 DE-627 ger DE-627 rakwb eng RK1-715 Shreyas H Gupte verfasserin aut Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline additives adrenaline clonidine hemodynamic variables local anesthetics Dentistry Rinku D Kalra verfasserin aut Thomson M Dcruz verfasserin aut Sahil Kamble verfasserin aut Ranjana S Patnaik verfasserin aut In Contemporary Clinical Dentistry Wolters Kluwer Medknow Publications, 2010 12(2021), 3, Seite 308-312 (DE-627)64057355X (DE-600)2582352-8 09762361 nnns volume:12 year:2021 number:3 pages:308-312 https://doi.org/10.4103/ccd.ccd_665_20 kostenfrei https://doaj.org/article/57084b8d06a94ef7a6a805d1caaa9bc7 kostenfrei http://www.contempclindent.org/article.asp?issn=0976-237X;year=2021;volume=12;issue=3;spage=308;epage=312;aulast=Gupte kostenfrei https://doaj.org/toc/0976-237X Journal toc kostenfrei https://doaj.org/toc/0976-2361 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 3 308-312
allfields_unstemmed	10.4103/ccd.ccd_665_20 doi (DE-627)DOAJ054801249 (DE-599)DOAJ57084b8d06a94ef7a6a805d1caaa9bc7 DE-627 ger DE-627 rakwb eng RK1-715 Shreyas H Gupte verfasserin aut Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline additives adrenaline clonidine hemodynamic variables local anesthetics Dentistry Rinku D Kalra verfasserin aut Thomson M Dcruz verfasserin aut Sahil Kamble verfasserin aut Ranjana S Patnaik verfasserin aut In Contemporary Clinical Dentistry Wolters Kluwer Medknow Publications, 2010 12(2021), 3, Seite 308-312 (DE-627)64057355X (DE-600)2582352-8 09762361 nnns volume:12 year:2021 number:3 pages:308-312 https://doi.org/10.4103/ccd.ccd_665_20 kostenfrei https://doaj.org/article/57084b8d06a94ef7a6a805d1caaa9bc7 kostenfrei http://www.contempclindent.org/article.asp?issn=0976-237X;year=2021;volume=12;issue=3;spage=308;epage=312;aulast=Gupte kostenfrei https://doaj.org/toc/0976-237X Journal toc kostenfrei https://doaj.org/toc/0976-2361 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 3 308-312
allfieldsGer	10.4103/ccd.ccd_665_20 doi (DE-627)DOAJ054801249 (DE-599)DOAJ57084b8d06a94ef7a6a805d1caaa9bc7 DE-627 ger DE-627 rakwb eng RK1-715 Shreyas H Gupte verfasserin aut Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline additives adrenaline clonidine hemodynamic variables local anesthetics Dentistry Rinku D Kalra verfasserin aut Thomson M Dcruz verfasserin aut Sahil Kamble verfasserin aut Ranjana S Patnaik verfasserin aut In Contemporary Clinical Dentistry Wolters Kluwer Medknow Publications, 2010 12(2021), 3, Seite 308-312 (DE-627)64057355X (DE-600)2582352-8 09762361 nnns volume:12 year:2021 number:3 pages:308-312 https://doi.org/10.4103/ccd.ccd_665_20 kostenfrei https://doaj.org/article/57084b8d06a94ef7a6a805d1caaa9bc7 kostenfrei http://www.contempclindent.org/article.asp?issn=0976-237X;year=2021;volume=12;issue=3;spage=308;epage=312;aulast=Gupte kostenfrei https://doaj.org/toc/0976-237X Journal toc kostenfrei https://doaj.org/toc/0976-2361 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 3 308-312
allfieldsSound	10.4103/ccd.ccd_665_20 doi (DE-627)DOAJ054801249 (DE-599)DOAJ57084b8d06a94ef7a6a805d1caaa9bc7 DE-627 ger DE-627 rakwb eng RK1-715 Shreyas H Gupte verfasserin aut Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline additives adrenaline clonidine hemodynamic variables local anesthetics Dentistry Rinku D Kalra verfasserin aut Thomson M Dcruz verfasserin aut Sahil Kamble verfasserin aut Ranjana S Patnaik verfasserin aut In Contemporary Clinical Dentistry Wolters Kluwer Medknow Publications, 2010 12(2021), 3, Seite 308-312 (DE-627)64057355X (DE-600)2582352-8 09762361 nnns volume:12 year:2021 number:3 pages:308-312 https://doi.org/10.4103/ccd.ccd_665_20 kostenfrei https://doaj.org/article/57084b8d06a94ef7a6a805d1caaa9bc7 kostenfrei http://www.contempclindent.org/article.asp?issn=0976-237X;year=2021;volume=12;issue=3;spage=308;epage=312;aulast=Gupte kostenfrei https://doaj.org/toc/0976-237X Journal toc kostenfrei https://doaj.org/toc/0976-2361 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 3 308-312
language	English
source	In Contemporary Clinical Dentistry 12(2021), 3, Seite 308-312 volume:12 year:2021 number:3 pages:308-312
sourceStr	In Contemporary Clinical Dentistry 12(2021), 3, Seite 308-312 volume:12 year:2021 number:3 pages:308-312
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	additives adrenaline clonidine hemodynamic variables local anesthetics Dentistry
isfreeaccess_bool	true
container_title	Contemporary Clinical Dentistry
authorswithroles_txt_mv	Shreyas H Gupte @@aut@@ Rinku D Kalra @@aut@@ Thomson M Dcruz @@aut@@ Sahil Kamble @@aut@@ Ranjana S Patnaik @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	64057355X
id	DOAJ054801249
language_de	englisch
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callnumber-first	R - Medicine
author	Shreyas H Gupte
spellingShingle	Shreyas H Gupte misc RK1-715 misc additives misc adrenaline misc clonidine misc hemodynamic variables misc local anesthetics misc Dentistry Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study
authorStr	Shreyas H Gupte
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topic_title	RK1-715 Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study additives adrenaline clonidine hemodynamic variables local anesthetics
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title	Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study
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title_full	Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study
author_sort	Shreyas H Gupte
journal	Contemporary Clinical Dentistry
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author_browse	Shreyas H Gupte Rinku D Kalra Thomson M Dcruz Sahil Kamble Ranjana S Patnaik
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doi_str_mv	10.4103/ccd.ccd_665_20
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title_sort	comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: a randomized controlled clinical study
callnumber	RK1-715
title_auth	Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study
abstract	Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline
abstractGer	Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline
abstract_unstemmed	Background and Objectives: Clonidine is a common additive to local anesthetics for various regional and local nerve blocks. However, its effectiveness in dentistry has not yet been fully explored. Thus, this study was performed to evaluate the quality of anesthesia, vasoconstrictive effects, hemodynamic response, and pain control using a solution of 2% lignocaine hydrochloride with clonidine hydrochloride in comparison with the standard solution of 2% lignocaine hydrochloride and adrenaline bitartrate for pterygomandibular nerve blocks. Materials and Methods: A parallel arm, triple-blind randomized controlled study was conducted on 152 patients belonging to ASA-I (American Society of Anesthesiologists) category in the age group of 18-45 years, requiring surgical extraction of impacted mandibular third molars. The patients were divided equally into two groups randomly by computer-generated sequence; Group 1: 2% lignocaine hydrochloride with 1 ml of clonidine hydrochloride (150 μg/ml) and Group 2: 2% lignocaine hydrochloride with adrenaline bitartrate 1: 80,000 (12.5 μg/ml). The variables evaluated were systolic, diastolic, and mean arterial blood pressures, heart rate (HR), blood loss, onset, depth (pain), and duration of anesthesia. Results: There was a statistically nonsignificant difference seen between the two groups (P < 0.05) for the onset of anesthesia, pain assessed, and blood loss, whereas a statistically highly significant difference was seen for cardiovascular variables (systolic, diastolic and mean arterial blood pressures, and HR) at various intervals with higher values for Group 2 (P < 0.001) and for the duration of action of local anesthesia (LA), with higher values for Group 1 (P < 0.001). Conclusions: Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline
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title_short	Comparative evaluation of effectiveness of 2% lignocaine hydrochloride with clonidine hydrochloride versus 2% lignocaine hydrochloride with adrenaline bitartrate as local anesthetic for adult patients undergoing surgical extraction of impacted mandibular third molars: A randomized controlled clinical study
url	https://doi.org/10.4103/ccd.ccd_665_20 https://doaj.org/article/57084b8d06a94ef7a6a805d1caaa9bc7 http://www.contempclindent.org/article.asp?issn=0976-237X;year=2021;volume=12;issue=3;spage=308;epage=312;aulast=Gupte https://doaj.org/toc/0976-237X https://doaj.org/toc/0976-2361
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author2	Rinku D Kalra Thomson M Dcruz Sahil Kamble Ranjana S Patnaik
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up_date	2024-07-04T00:39:33.144Z
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