High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study

Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Deepjyoti Kalita [verfasserIn] Ridip Kumar Sarma [verfasserIn] Kripesh Ranjan Sharma [verfasserIn] Sangeeta Deka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia

Übergeordnetes Werk:	In: Lung India - Wolters Kluwer Medknow Publications, 2009, 38(2021), 5, Seite 460-465
Übergeordnetes Werk:	volume:38 ; year:2021 ; number:5 ; pages:460-465

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/lungindia.lungindia_978_20

Katalog-ID:	DOAJ054809304

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520			\|a Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour.
650		4	\|a adult community-acquired pneumonia
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allfields	10.4103/lungindia.lungindia_978_20 doi (DE-627)DOAJ054809304 (DE-599)DOAJa0950c0d715a4b5594cbb51577d83bff DE-627 ger DE-627 rakwb eng RC705-779 Deepjyoti Kalita verfasserin aut High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour. adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia Diseases of the respiratory system Ridip Kumar Sarma verfasserin aut Kripesh Ranjan Sharma verfasserin aut Sangeeta Deka verfasserin aut In Lung India Wolters Kluwer Medknow Publications, 2009 38(2021), 5, Seite 460-465 (DE-627)558697895 (DE-600)2410801-7 0974598X nnns volume:38 year:2021 number:5 pages:460-465 https://doi.org/10.4103/lungindia.lungindia_978_20 kostenfrei https://doaj.org/article/a0950c0d715a4b5594cbb51577d83bff kostenfrei http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=5;spage=460;epage=465;aulast=Kalita kostenfrei https://doaj.org/toc/0970-2113 Journal toc kostenfrei https://doaj.org/toc/0974-598X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 38 2021 5 460-465
spelling	10.4103/lungindia.lungindia_978_20 doi (DE-627)DOAJ054809304 (DE-599)DOAJa0950c0d715a4b5594cbb51577d83bff DE-627 ger DE-627 rakwb eng RC705-779 Deepjyoti Kalita verfasserin aut High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour. adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia Diseases of the respiratory system Ridip Kumar Sarma verfasserin aut Kripesh Ranjan Sharma verfasserin aut Sangeeta Deka verfasserin aut In Lung India Wolters Kluwer Medknow Publications, 2009 38(2021), 5, Seite 460-465 (DE-627)558697895 (DE-600)2410801-7 0974598X nnns volume:38 year:2021 number:5 pages:460-465 https://doi.org/10.4103/lungindia.lungindia_978_20 kostenfrei https://doaj.org/article/a0950c0d715a4b5594cbb51577d83bff kostenfrei http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=5;spage=460;epage=465;aulast=Kalita kostenfrei https://doaj.org/toc/0970-2113 Journal toc kostenfrei https://doaj.org/toc/0974-598X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 38 2021 5 460-465
allfields_unstemmed	10.4103/lungindia.lungindia_978_20 doi (DE-627)DOAJ054809304 (DE-599)DOAJa0950c0d715a4b5594cbb51577d83bff DE-627 ger DE-627 rakwb eng RC705-779 Deepjyoti Kalita verfasserin aut High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour. adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia Diseases of the respiratory system Ridip Kumar Sarma verfasserin aut Kripesh Ranjan Sharma verfasserin aut Sangeeta Deka verfasserin aut In Lung India Wolters Kluwer Medknow Publications, 2009 38(2021), 5, Seite 460-465 (DE-627)558697895 (DE-600)2410801-7 0974598X nnns volume:38 year:2021 number:5 pages:460-465 https://doi.org/10.4103/lungindia.lungindia_978_20 kostenfrei https://doaj.org/article/a0950c0d715a4b5594cbb51577d83bff kostenfrei http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=5;spage=460;epage=465;aulast=Kalita kostenfrei https://doaj.org/toc/0970-2113 Journal toc kostenfrei https://doaj.org/toc/0974-598X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 38 2021 5 460-465
allfieldsGer	10.4103/lungindia.lungindia_978_20 doi (DE-627)DOAJ054809304 (DE-599)DOAJa0950c0d715a4b5594cbb51577d83bff DE-627 ger DE-627 rakwb eng RC705-779 Deepjyoti Kalita verfasserin aut High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour. adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia Diseases of the respiratory system Ridip Kumar Sarma verfasserin aut Kripesh Ranjan Sharma verfasserin aut Sangeeta Deka verfasserin aut In Lung India Wolters Kluwer Medknow Publications, 2009 38(2021), 5, Seite 460-465 (DE-627)558697895 (DE-600)2410801-7 0974598X nnns volume:38 year:2021 number:5 pages:460-465 https://doi.org/10.4103/lungindia.lungindia_978_20 kostenfrei https://doaj.org/article/a0950c0d715a4b5594cbb51577d83bff kostenfrei http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=5;spage=460;epage=465;aulast=Kalita kostenfrei https://doaj.org/toc/0970-2113 Journal toc kostenfrei https://doaj.org/toc/0974-598X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 38 2021 5 460-465
allfieldsSound	10.4103/lungindia.lungindia_978_20 doi (DE-627)DOAJ054809304 (DE-599)DOAJa0950c0d715a4b5594cbb51577d83bff DE-627 ger DE-627 rakwb eng RC705-779 Deepjyoti Kalita verfasserin aut High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour. adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia Diseases of the respiratory system Ridip Kumar Sarma verfasserin aut Kripesh Ranjan Sharma verfasserin aut Sangeeta Deka verfasserin aut In Lung India Wolters Kluwer Medknow Publications, 2009 38(2021), 5, Seite 460-465 (DE-627)558697895 (DE-600)2410801-7 0974598X nnns volume:38 year:2021 number:5 pages:460-465 https://doi.org/10.4103/lungindia.lungindia_978_20 kostenfrei https://doaj.org/article/a0950c0d715a4b5594cbb51577d83bff kostenfrei http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=5;spage=460;epage=465;aulast=Kalita kostenfrei https://doaj.org/toc/0970-2113 Journal toc kostenfrei https://doaj.org/toc/0974-598X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 38 2021 5 460-465
language	English
source	In Lung India 38(2021), 5, Seite 460-465 volume:38 year:2021 number:5 pages:460-465
sourceStr	In Lung India 38(2021), 5, Seite 460-465 volume:38 year:2021 number:5 pages:460-465
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia Diseases of the respiratory system
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container_title	Lung India
authorswithroles_txt_mv	Deepjyoti Kalita @@aut@@ Ridip Kumar Sarma @@aut@@ Kripesh Ranjan Sharma @@aut@@ Sangeeta Deka @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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language_de	englisch
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Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. 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callnumber-first	R - Medicine
author	Deepjyoti Kalita
spellingShingle	Deepjyoti Kalita misc RC705-779 misc adult community-acquired pneumonia misc atypical agents misc community-acquired pneumonia misc drug-resistant pneumococci misc drug-resistant streptococcus pneumonia misc macrolide resistance misc multidrug resistance misc multidrug-resistant streptococcus pneumonia misc Diseases of the respiratory system High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study
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topic_title	RC705-779 High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study adult community-acquired pneumonia atypical agents community-acquired pneumonia drug-resistant pneumococci drug-resistant streptococcus pneumonia macrolide resistance multidrug resistance multidrug-resistant streptococcus pneumonia
topic	misc RC705-779 misc adult community-acquired pneumonia misc atypical agents misc community-acquired pneumonia misc drug-resistant pneumococci misc drug-resistant streptococcus pneumonia misc macrolide resistance misc multidrug resistance misc multidrug-resistant streptococcus pneumonia misc Diseases of the respiratory system
topic_unstemmed	misc RC705-779 misc adult community-acquired pneumonia misc atypical agents misc community-acquired pneumonia misc drug-resistant pneumococci misc drug-resistant streptococcus pneumonia misc macrolide resistance misc multidrug resistance misc multidrug-resistant streptococcus pneumonia misc Diseases of the respiratory system
topic_browse	misc RC705-779 misc adult community-acquired pneumonia misc atypical agents misc community-acquired pneumonia misc drug-resistant pneumococci misc drug-resistant streptococcus pneumonia misc macrolide resistance misc multidrug resistance misc multidrug-resistant streptococcus pneumonia misc Diseases of the respiratory system
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title	High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study
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title_full	High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study
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author_browse	Deepjyoti Kalita Ridip Kumar Sarma Kripesh Ranjan Sharma Sangeeta Deka
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title_sort	high proportion of drug-resistant isolates in adult community-acquired pneumonia from northeast india: a hospital-based study
callnumber	RC705-779
title_auth	High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study
abstract	Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour.
abstractGer	Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour.
abstract_unstemmed	Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Methods: This cross-sectional study was done on adult CAP patients from medicine, respiratory medicine, and intensive care unit area in our tertiary care hospital between May 1, 2015, and October 30, 2016. Subjects were enrolled continuously, and expectorated sputum, bronchoalveolar lavage fluid, and blood culture were performed. Urine antigen test was done for Streptococcus pneumoniae and Legionella pneumophila. Three types of ELISA (IgM, IgG, and IgA) were performed for atypical agents (Mycoplasma, Chlamydia, and Legionella) of CAP. Isolates obtained from culture of Sputum/BAL/Blood were further processed for antibiotic susceptibility testing - by disc diffusion as well as E-test method (latter for MIC i.e. minimum inhibitory concentration, determination). Results: About 574 subjects were included, and in 266 (46.3%) cases, bacterial pathogen could be detected. Klebsiella pneumoniae (33.6%) and S. pneumoniae (32.9%) were the predominant agents identified. Atypical agents (Mycoplasma, Legionella, and Chlamydia) were at 15.1%. A high proportion of pneumococci isolates were multidrug resistant (52.6%). Resistance to beta-lactams, macrolide, and other agents was on the higher side, but fluoroquinolones were found to be less resistant (15.8%–21.1%). Extended-spectrum beta-lactamase (among Klebsiella isolates) and methicillin-resistant Staphylococcus aureus were also detected. Conclusion: A moderate-to-high degree of drug-resistant in adult CAP was evident, which is detrimental in effective empirical management of such cases. Urgent implementation of antibiotic stewardship scheme is the need of the hour.
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title_short	High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study
url	https://doi.org/10.4103/lungindia.lungindia_978_20 https://doaj.org/article/a0950c0d715a4b5594cbb51577d83bff http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=5;spage=460;epage=465;aulast=Kalita https://doaj.org/toc/0970-2113 https://doaj.org/toc/0974-598X
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High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study

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