The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza

In this review, we discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection. Importantly, we cover the current understanding on the mechanisms by which SARS-CoV-2 may fail to engage a coordin...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sabina Sahanic [verfasserIn] Judith Löffler-Ragg [verfasserIn] Piotr Tymoszuk [verfasserIn] Richard Hilbe [verfasserIn] Egon Demetz [verfasserIn] Rebecca K Masanetz [verfasserIn] Markus Theurl [verfasserIn] Johannes Holfeld [verfasserIn] Can Gollmann-Tepeköylü [verfasserIn] Alexandar Tzankov [verfasserIn] Guenter Weiss [verfasserIn] Martin Giera [verfasserIn] Ivan Tancevski [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	innate immunity COVID-19 lipid mediator metabololipidomics influenza virus macrophages and neutrophils

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2021.688946

Katalog-ID:	DOAJ054815347

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author	Sabina Sahanic
spellingShingle	Sabina Sahanic misc QP1-981 misc innate immunity misc COVID-19 misc lipid mediator misc metabololipidomics misc influenza virus misc macrophages and neutrophils misc Physiology The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza
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topic_title	QP1-981 The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza innate immunity COVID-19 lipid mediator metabololipidomics influenza virus macrophages and neutrophils
topic	misc QP1-981 misc innate immunity misc COVID-19 misc lipid mediator misc metabololipidomics misc influenza virus misc macrophages and neutrophils misc Physiology
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title	The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza
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title_auth	The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza
abstract	In this review, we discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection. Importantly, we cover the current understanding on the mechanisms by which SARS-CoV-2 may fail to engage a coordinated type I response and instead may lead to exaggerated inflammation and death. This knowledge is central for the understanding of available data on specialized pro-resolving lipid mediators in severe SARS-CoV-2 infection pointing toward inhibited E-series resolvin synthesis in severe cases. By investigating a publicly available RNA-seq database of bronchoalveolar lavage cells from patients affected by COVID-19, we moreover offer insights into the regulation of key enzymes involved in lipid mediator synthesis, critically complementing the current knowledge about the mediator lipidome in severely affected patients. This review finally discusses different potential approaches to sustain the synthesis of 3-PUFA-derived pro-resolving lipid mediators, including resolvins and lipoxins, which may critically aid in the prevention of acute lung injury and death from COVID-19.
abstractGer	In this review, we discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection. Importantly, we cover the current understanding on the mechanisms by which SARS-CoV-2 may fail to engage a coordinated type I response and instead may lead to exaggerated inflammation and death. This knowledge is central for the understanding of available data on specialized pro-resolving lipid mediators in severe SARS-CoV-2 infection pointing toward inhibited E-series resolvin synthesis in severe cases. By investigating a publicly available RNA-seq database of bronchoalveolar lavage cells from patients affected by COVID-19, we moreover offer insights into the regulation of key enzymes involved in lipid mediator synthesis, critically complementing the current knowledge about the mediator lipidome in severely affected patients. This review finally discusses different potential approaches to sustain the synthesis of 3-PUFA-derived pro-resolving lipid mediators, including resolvins and lipoxins, which may critically aid in the prevention of acute lung injury and death from COVID-19.
abstract_unstemmed	In this review, we discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection. Importantly, we cover the current understanding on the mechanisms by which SARS-CoV-2 may fail to engage a coordinated type I response and instead may lead to exaggerated inflammation and death. This knowledge is central for the understanding of available data on specialized pro-resolving lipid mediators in severe SARS-CoV-2 infection pointing toward inhibited E-series resolvin synthesis in severe cases. By investigating a publicly available RNA-seq database of bronchoalveolar lavage cells from patients affected by COVID-19, we moreover offer insights into the regulation of key enzymes involved in lipid mediator synthesis, critically complementing the current knowledge about the mediator lipidome in severely affected patients. This review finally discusses different potential approaches to sustain the synthesis of 3-PUFA-derived pro-resolving lipid mediators, including resolvins and lipoxins, which may critically aid in the prevention of acute lung injury and death from COVID-19.
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title_short	The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza
url	https://doi.org/10.3389/fphys.2021.688946 https://doaj.org/article/5c4b9d0a77e34c118a01e0d8a13a63d6 https://www.frontiersin.org/articles/10.3389/fphys.2021.688946/full https://doaj.org/toc/1664-042X
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up_date	2024-07-04T00:42:46.463Z
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The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza

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