Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views

Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current...
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Gespeichert in:

Autor*in:	Moon Jong Kim [verfasserIn] Yuanjian Huang [verfasserIn] Jae-Il Park [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Wnt signaling β-catenin cancer gastrointestinal cancers therapeutic targeting of Wnt signaling β-catenin paradox

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2020), 12, p 3638
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:12, p 3638

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12123638

Katalog-ID:	DOAJ054870046

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source	In Cancers 12(2020), 12, p 3638 volume:12 year:2020 number:12, p 3638
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institution	findex.gbv.de
topic_facet	Wnt signaling β-catenin cancer gastrointestinal cancers therapeutic targeting of Wnt signaling β-catenin paradox Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
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callnumber-first	R - Medicine
author	Moon Jong Kim
spellingShingle	Moon Jong Kim misc RC254-282 misc Wnt signaling misc β-catenin misc cancer misc gastrointestinal cancers misc therapeutic targeting of Wnt signaling misc β-catenin paradox misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
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topic_title	RC254-282 Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views Wnt signaling β-catenin cancer gastrointestinal cancers therapeutic targeting of Wnt signaling β-catenin paradox
topic	misc RC254-282 misc Wnt signaling misc β-catenin misc cancer misc gastrointestinal cancers misc therapeutic targeting of Wnt signaling misc β-catenin paradox misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
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title_full	Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
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title_sort	targeting wnt signaling for gastrointestinal cancer therapy: present and evolving views
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title_auth	Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
abstract	Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.
abstractGer	Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.
abstract_unstemmed	Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.
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title_short	Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
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