Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs
As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we asses...
Ausführliche Beschreibung
Autor*in: |
Amir Arastehfar [verfasserIn] Tahmineh Shaban [verfasserIn] Hossein Zarrinfar [verfasserIn] Maryam Roudbary [verfasserIn] Mona Ghazanfari [verfasserIn] Mohammad-Taghi Hedayati [verfasserIn] Alireza Sedaghat [verfasserIn] Macit Ilkit [verfasserIn] Mohammad Javad Najafzadeh [verfasserIn] David S. Perlin [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Journal of Fungi - MDPI AG, 2015, 7(2021), 4, p 280 |
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Übergeordnetes Werk: |
volume:7 ; year:2021 ; number:4, p 280 |
Links: |
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DOI / URN: |
10.3390/jof7040280 |
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Katalog-ID: |
DOAJ054878624 |
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10.3390/jof7040280 doi (DE-627)DOAJ054878624 (DE-599)DOAJ2082c129806e4c24bbd7c03190ff77b3 DE-627 ger DE-627 rakwb eng QH301-705.5 Amir Arastehfar verfasserin aut Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. The high mortality of patients with CAC, despite antifungal therapy, reflects the severity of the disease in these patients and underscores the importance of rapid diagnosis and timely initiation of antifungal treatment. COVID-19 COVID-19-associated candidemia multidrug resistance <i<Candida albicans</i< <i<Candida glabrata</i< <i<Rhodotorula mucilaginosa</i< Biology (General) Tahmineh Shaban verfasserin aut Hossein Zarrinfar verfasserin aut Maryam Roudbary verfasserin aut Mona Ghazanfari verfasserin aut Mohammad-Taghi Hedayati verfasserin aut Alireza Sedaghat verfasserin aut Macit Ilkit verfasserin aut Mohammad Javad Najafzadeh verfasserin aut David S. Perlin verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 4, p 280 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:4, p 280 https://doi.org/10.3390/jof7040280 kostenfrei https://doaj.org/article/2082c129806e4c24bbd7c03190ff77b3 kostenfrei https://www.mdpi.com/2309-608X/7/4/280 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 4, p 280 |
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10.3390/jof7040280 doi (DE-627)DOAJ054878624 (DE-599)DOAJ2082c129806e4c24bbd7c03190ff77b3 DE-627 ger DE-627 rakwb eng QH301-705.5 Amir Arastehfar verfasserin aut Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. The high mortality of patients with CAC, despite antifungal therapy, reflects the severity of the disease in these patients and underscores the importance of rapid diagnosis and timely initiation of antifungal treatment. COVID-19 COVID-19-associated candidemia multidrug resistance <i<Candida albicans</i< <i<Candida glabrata</i< <i<Rhodotorula mucilaginosa</i< Biology (General) Tahmineh Shaban verfasserin aut Hossein Zarrinfar verfasserin aut Maryam Roudbary verfasserin aut Mona Ghazanfari verfasserin aut Mohammad-Taghi Hedayati verfasserin aut Alireza Sedaghat verfasserin aut Macit Ilkit verfasserin aut Mohammad Javad Najafzadeh verfasserin aut David S. Perlin verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 4, p 280 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:4, p 280 https://doi.org/10.3390/jof7040280 kostenfrei https://doaj.org/article/2082c129806e4c24bbd7c03190ff77b3 kostenfrei https://www.mdpi.com/2309-608X/7/4/280 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 4, p 280 |
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10.3390/jof7040280 doi (DE-627)DOAJ054878624 (DE-599)DOAJ2082c129806e4c24bbd7c03190ff77b3 DE-627 ger DE-627 rakwb eng QH301-705.5 Amir Arastehfar verfasserin aut Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. The high mortality of patients with CAC, despite antifungal therapy, reflects the severity of the disease in these patients and underscores the importance of rapid diagnosis and timely initiation of antifungal treatment. COVID-19 COVID-19-associated candidemia multidrug resistance <i<Candida albicans</i< <i<Candida glabrata</i< <i<Rhodotorula mucilaginosa</i< Biology (General) Tahmineh Shaban verfasserin aut Hossein Zarrinfar verfasserin aut Maryam Roudbary verfasserin aut Mona Ghazanfari verfasserin aut Mohammad-Taghi Hedayati verfasserin aut Alireza Sedaghat verfasserin aut Macit Ilkit verfasserin aut Mohammad Javad Najafzadeh verfasserin aut David S. Perlin verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 4, p 280 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:4, p 280 https://doi.org/10.3390/jof7040280 kostenfrei https://doaj.org/article/2082c129806e4c24bbd7c03190ff77b3 kostenfrei https://www.mdpi.com/2309-608X/7/4/280 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 4, p 280 |
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10.3390/jof7040280 doi (DE-627)DOAJ054878624 (DE-599)DOAJ2082c129806e4c24bbd7c03190ff77b3 DE-627 ger DE-627 rakwb eng QH301-705.5 Amir Arastehfar verfasserin aut Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. The high mortality of patients with CAC, despite antifungal therapy, reflects the severity of the disease in these patients and underscores the importance of rapid diagnosis and timely initiation of antifungal treatment. COVID-19 COVID-19-associated candidemia multidrug resistance <i<Candida albicans</i< <i<Candida glabrata</i< <i<Rhodotorula mucilaginosa</i< Biology (General) Tahmineh Shaban verfasserin aut Hossein Zarrinfar verfasserin aut Maryam Roudbary verfasserin aut Mona Ghazanfari verfasserin aut Mohammad-Taghi Hedayati verfasserin aut Alireza Sedaghat verfasserin aut Macit Ilkit verfasserin aut Mohammad Javad Najafzadeh verfasserin aut David S. Perlin verfasserin aut In Journal of Fungi MDPI AG, 2015 7(2021), 4, p 280 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:7 year:2021 number:4, p 280 https://doi.org/10.3390/jof7040280 kostenfrei https://doaj.org/article/2082c129806e4c24bbd7c03190ff77b3 kostenfrei https://www.mdpi.com/2309-608X/7/4/280 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 4, p 280 |
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Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs |
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As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. The high mortality of patients with CAC, despite antifungal therapy, reflects the severity of the disease in these patients and underscores the importance of rapid diagnosis and timely initiation of antifungal treatment. |
abstractGer |
As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. The high mortality of patients with CAC, despite antifungal therapy, reflects the severity of the disease in these patients and underscores the importance of rapid diagnosis and timely initiation of antifungal treatment. |
abstract_unstemmed |
As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. The high mortality of patients with CAC, despite antifungal therapy, reflects the severity of the disease in these patients and underscores the importance of rapid diagnosis and timely initiation of antifungal treatment. |
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Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the intensive care units (ICUs) of two COVID-19 centers in Mashhad, Iran, from early November 2020 to late January 2021. Yeast isolates from patients’ blood were identified by 21-plex polymerase chain reaction (PCR) and sequencing, then subjected to antifungal susceptibility testing according to the CLSI M27-A3 protocol. Among 1988 patients with COVID-19 admitted to ICUs, seven had fungemia (7/1988; 0.03%), among whom six had CAC. The mortality of the limited CAC cases was high and greatly exceeded that of patients with COVID-19 but without candidemia (100% (6/6) vs. 22.7% (452/1988)). In total, nine yeast isolates were collected from patients with fungemia: five <i<Candida albicans</i<, three <i<C. glabrata</i<, and one <i<Rhodotorula mucilaginosa</i<. Half of the patients infected with <i<C. albicans</i< (2/4) were refractory to both azoles and echinocandins. 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