Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation

Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine t...
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Autor*in:	Melissa L Wilkinson [verfasserIn] Andrew J Gow [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Innate Immunity - SAGE Publishing, 2020, 27(2021)
Übergeordnetes Werk:	volume:27 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1177/17534259211015330

Katalog-ID:	DOAJ054890241

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520			\|a Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO 2 -FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein’s expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO 2 -FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO 2 -FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury.
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allfields	10.1177/17534259211015330 doi (DE-627)DOAJ054890241 (DE-599)DOAJa84e83cb6a50438b883cc4e488055474 DE-627 ger DE-627 rakwb eng RC581-607 Melissa L Wilkinson verfasserin aut Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO 2 -FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein’s expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO 2 -FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO 2 -FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury. Immunologic diseases. Allergy Andrew J Gow verfasserin aut In Innate Immunity SAGE Publishing, 2020 27(2021) (DE-627)539000159 (DE-600)2381250-3 17534267 nnns volume:27 year:2021 https://doi.org/10.1177/17534259211015330 kostenfrei https://doaj.org/article/a84e83cb6a50438b883cc4e488055474 kostenfrei https://doi.org/10.1177/17534259211015330 kostenfrei https://doaj.org/toc/1753-4259 Journal toc kostenfrei https://doaj.org/toc/1753-4267 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2021
spelling	10.1177/17534259211015330 doi (DE-627)DOAJ054890241 (DE-599)DOAJa84e83cb6a50438b883cc4e488055474 DE-627 ger DE-627 rakwb eng RC581-607 Melissa L Wilkinson verfasserin aut Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO 2 -FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein’s expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO 2 -FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO 2 -FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury. Immunologic diseases. Allergy Andrew J Gow verfasserin aut In Innate Immunity SAGE Publishing, 2020 27(2021) (DE-627)539000159 (DE-600)2381250-3 17534267 nnns volume:27 year:2021 https://doi.org/10.1177/17534259211015330 kostenfrei https://doaj.org/article/a84e83cb6a50438b883cc4e488055474 kostenfrei https://doi.org/10.1177/17534259211015330 kostenfrei https://doaj.org/toc/1753-4259 Journal toc kostenfrei https://doaj.org/toc/1753-4267 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2021
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allfieldsSound	10.1177/17534259211015330 doi (DE-627)DOAJ054890241 (DE-599)DOAJa84e83cb6a50438b883cc4e488055474 DE-627 ger DE-627 rakwb eng RC581-607 Melissa L Wilkinson verfasserin aut Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO 2 -FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein’s expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO 2 -FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO 2 -FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury. Immunologic diseases. Allergy Andrew J Gow verfasserin aut In Innate Immunity SAGE Publishing, 2020 27(2021) (DE-627)539000159 (DE-600)2381250-3 17534267 nnns volume:27 year:2021 https://doi.org/10.1177/17534259211015330 kostenfrei https://doaj.org/article/a84e83cb6a50438b883cc4e488055474 kostenfrei https://doi.org/10.1177/17534259211015330 kostenfrei https://doaj.org/toc/1753-4259 Journal toc kostenfrei https://doaj.org/toc/1753-4267 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_121 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2021
language	English
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callnumber-first	R - Medicine
author	Melissa L Wilkinson
spellingShingle	Melissa L Wilkinson misc RC581-607 misc Immunologic diseases. Allergy Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
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topic_title	RC581-607 Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
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title	Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
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title_full	Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
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title_sort	effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
callnumber	RC581-607
title_auth	Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
abstract	Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO 2 -FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein’s expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO 2 -FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO 2 -FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury.
abstractGer	Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO 2 -FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein’s expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO 2 -FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO 2 -FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury.
abstract_unstemmed	Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and display anti-inflammatory, pro-survival actions. These actions are elicited through the alteration of signal transduction proteins via a Michael addition on nucleophilic cysteine thiols. Nitrated fatty acids (NO 2 -FAs), like 9- or 10-nitro-octadec-9-enolic acid, will act on signal transduction proteins directly or on key regulatory proteins to cause an up-regulation or down-regulation of the protein’s expression, yielding an anti-inflammatory response. These responses have been characterized in many organ systems, such as the cardiovascular system, with the pulmonary system less well defined. Macrophages are one of the most abundant immune cells in the lung and are essential in maintaining lung homeostasis. Despite this, macrophages can play a role in both acute and chronic lung injury due to up-regulation of anti-inflammatory signal transduction pathways and down-regulation of pro-inflammatory pathways. Through their propensity to alter signal transduction pathways, NO 2 -FAs may be able to reduce macrophage activation during pulmonary injury. This review will focus on the implications of NO 2 -FAs on macrophage activation in the lung and the signal transduction pathways that may be altered, leading to reduced pulmonary injury.
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title_short	Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
url	https://doi.org/10.1177/17534259211015330 https://doaj.org/article/a84e83cb6a50438b883cc4e488055474 https://doaj.org/toc/1753-4259 https://doaj.org/toc/1753-4267
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