Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study

The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Thibaud Mathis [verfasserIn] Sarra Dimassi [verfasserIn] Olivier Loria [verfasserIn] Aditya Sudhalkar [verfasserIn] Alper Bilgic [verfasserIn] Philippe Denis [verfasserIn] Pierre Pradat [verfasserIn] Laurent Kodjikian [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	age-related macular degeneration exudation optical coherence tomography angiography

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 7, p 1524
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:7, p 1524

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10071524

Katalog-ID:	DOAJ054920124

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520			\|a The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD.
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allfields	10.3390/jcm10071524 doi (DE-627)DOAJ054920124 (DE-599)DOAJe33b5269a18f42209ab4fea7f3ae5c4c DE-627 ger DE-627 rakwb eng Thibaud Mathis verfasserin aut Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD. age-related macular degeneration exudation optical coherence tomography angiography Medicine R Sarra Dimassi verfasserin aut Olivier Loria verfasserin aut Aditya Sudhalkar verfasserin aut Alper Bilgic verfasserin aut Philippe Denis verfasserin aut Pierre Pradat verfasserin aut Laurent Kodjikian verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 7, p 1524 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:7, p 1524 https://doi.org/10.3390/jcm10071524 kostenfrei https://doaj.org/article/e33b5269a18f42209ab4fea7f3ae5c4c kostenfrei https://www.mdpi.com/2077-0383/10/7/1524 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 7, p 1524
spelling	10.3390/jcm10071524 doi (DE-627)DOAJ054920124 (DE-599)DOAJe33b5269a18f42209ab4fea7f3ae5c4c DE-627 ger DE-627 rakwb eng Thibaud Mathis verfasserin aut Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD. age-related macular degeneration exudation optical coherence tomography angiography Medicine R Sarra Dimassi verfasserin aut Olivier Loria verfasserin aut Aditya Sudhalkar verfasserin aut Alper Bilgic verfasserin aut Philippe Denis verfasserin aut Pierre Pradat verfasserin aut Laurent Kodjikian verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 7, p 1524 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:7, p 1524 https://doi.org/10.3390/jcm10071524 kostenfrei https://doaj.org/article/e33b5269a18f42209ab4fea7f3ae5c4c kostenfrei https://www.mdpi.com/2077-0383/10/7/1524 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 7, p 1524
allfields_unstemmed	10.3390/jcm10071524 doi (DE-627)DOAJ054920124 (DE-599)DOAJe33b5269a18f42209ab4fea7f3ae5c4c DE-627 ger DE-627 rakwb eng Thibaud Mathis verfasserin aut Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD. age-related macular degeneration exudation optical coherence tomography angiography Medicine R Sarra Dimassi verfasserin aut Olivier Loria verfasserin aut Aditya Sudhalkar verfasserin aut Alper Bilgic verfasserin aut Philippe Denis verfasserin aut Pierre Pradat verfasserin aut Laurent Kodjikian verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 7, p 1524 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:7, p 1524 https://doi.org/10.3390/jcm10071524 kostenfrei https://doaj.org/article/e33b5269a18f42209ab4fea7f3ae5c4c kostenfrei https://www.mdpi.com/2077-0383/10/7/1524 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 7, p 1524
allfieldsGer	10.3390/jcm10071524 doi (DE-627)DOAJ054920124 (DE-599)DOAJe33b5269a18f42209ab4fea7f3ae5c4c DE-627 ger DE-627 rakwb eng Thibaud Mathis verfasserin aut Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD. age-related macular degeneration exudation optical coherence tomography angiography Medicine R Sarra Dimassi verfasserin aut Olivier Loria verfasserin aut Aditya Sudhalkar verfasserin aut Alper Bilgic verfasserin aut Philippe Denis verfasserin aut Pierre Pradat verfasserin aut Laurent Kodjikian verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 7, p 1524 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:7, p 1524 https://doi.org/10.3390/jcm10071524 kostenfrei https://doaj.org/article/e33b5269a18f42209ab4fea7f3ae5c4c kostenfrei https://www.mdpi.com/2077-0383/10/7/1524 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 7, p 1524
allfieldsSound	10.3390/jcm10071524 doi (DE-627)DOAJ054920124 (DE-599)DOAJe33b5269a18f42209ab4fea7f3ae5c4c DE-627 ger DE-627 rakwb eng Thibaud Mathis verfasserin aut Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD. age-related macular degeneration exudation optical coherence tomography angiography Medicine R Sarra Dimassi verfasserin aut Olivier Loria verfasserin aut Aditya Sudhalkar verfasserin aut Alper Bilgic verfasserin aut Philippe Denis verfasserin aut Pierre Pradat verfasserin aut Laurent Kodjikian verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 7, p 1524 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:7, p 1524 https://doi.org/10.3390/jcm10071524 kostenfrei https://doaj.org/article/e33b5269a18f42209ab4fea7f3ae5c4c kostenfrei https://www.mdpi.com/2077-0383/10/7/1524 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 7, p 1524
language	English
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author	Thibaud Mathis
spellingShingle	Thibaud Mathis misc age-related macular degeneration misc exudation misc optical coherence tomography angiography misc Medicine misc R Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study
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topic_title	Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study age-related macular degeneration exudation optical coherence tomography angiography
topic	misc age-related macular degeneration misc exudation misc optical coherence tomography angiography misc Medicine misc R
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title	Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study
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title_sort	retinal vascularization analysis on optical coherence tomography angiography before and after intraretinal or subretinal fluid resorption in exudative age-related macular degeneration: a pilot study
title_auth	Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study
abstract	The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD.
abstractGer	The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD.
abstract_unstemmed	The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. The present study shows that retinal vascular changes do occur in the case of exudative AMD.
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doi_str	10.3390/jcm10071524
up_date	2024-07-04T01:07:14.080Z
_version_	1803608637131718656
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ054920124</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412184919.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/jcm10071524</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ054920124</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe33b5269a18f42209ab4fea7f3ae5c4c</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Thibaud Mathis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The aim was to analyze the variations in macular vascularization on optical coherence tomography angiography (OCTA) according to the presence of intraretinal fluid (IRF) induced by exudative age-related macular degeneration (AMD). We included exudative AMD patients with IRF and/or subretinal fluid (SRF) and age-matched control eyes. All patients underwent a macular 6 × 6 mm swept-source OCTA. The mean perfusion density (MPD) and mean vascular density (MVD) were calculated in the superficial (SCP) and the deep (DCP) capillary plexus at two timepoints: during an episode of exudation (T0) and after its total resorption (T1). A total of 22 eyes in the IRF ± SRF group, 11 eyes in the SRF group and 11 eyes in the healthy group were analyzed. At T0, the IRF ± SRF group showed significantly lower MPD and MVD than healthy eyes in the SCP (<i<p</i< < 0.001) and DCP (<i<p</i< < 0.001). At T1, MPD and MVD significantly increased from T0 in the SCP (<i<p</i< = 0.027 and <i<p</i< = 0.0093) and DCP (<i<p</i< = 0.013 and <i<p</i< = 0.046) but remained statistically lower than in the healthy eyes. For the SRF group, only the DCP showed significantly lower MPD (<i<p</i< = 0.012) and MVD (<i<p</i< = 0.046) in comparison to the healthy eyes at T0. 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Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study

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