Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells

Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellu...
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Autor*in:	Yaning Shi [verfasserIn] Jennifer Kovacs-Nolan [verfasserIn] Bo Jiang [verfasserIn] Rong Tsao [verfasserIn] Yoshinori Mine [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 11(2014), Seite 571-580
Übergeordnetes Werk:	volume:11 ; year:2014 ; pages:571-580

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2014.08.017

Katalog-ID:	DOAJ054971772

Internformat


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520			\|a Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste.
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650		4	\|a Oxidative stress
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650		4	\|a Glutathione synthesis
653		0	\|a Nutrition. Foods and food supply
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700	0		\|a Bo Jiang \|e verfasserin \|4 aut
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700	0		\|a Yoshinori Mine \|e verfasserin \|4 aut
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912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
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912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
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912			\|a GBV_ILN_4251
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912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
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951			\|a AR
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publishDate	2014
allfields	10.1016/j.jff.2014.08.017 doi (DE-627)DOAJ054971772 (DE-599)DOAJ8f9b10d5dfe7440ab84e0dae52536093 DE-627 ger DE-627 rakwb eng TX341-641 Yaning Shi verfasserin aut Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste. Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis Nutrition. Foods and food supply Jennifer Kovacs-Nolan verfasserin aut Bo Jiang verfasserin aut Rong Tsao verfasserin aut Yoshinori Mine verfasserin aut In Journal of Functional Foods Elsevier, 2021 11(2014), Seite 571-580 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:11 year:2014 pages:571-580 https://doi.org/10.1016/j.jff.2014.08.017 kostenfrei https://doaj.org/article/8f9b10d5dfe7440ab84e0dae52536093 kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461400276X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2014 571-580
spelling	10.1016/j.jff.2014.08.017 doi (DE-627)DOAJ054971772 (DE-599)DOAJ8f9b10d5dfe7440ab84e0dae52536093 DE-627 ger DE-627 rakwb eng TX341-641 Yaning Shi verfasserin aut Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste. Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis Nutrition. Foods and food supply Jennifer Kovacs-Nolan verfasserin aut Bo Jiang verfasserin aut Rong Tsao verfasserin aut Yoshinori Mine verfasserin aut In Journal of Functional Foods Elsevier, 2021 11(2014), Seite 571-580 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:11 year:2014 pages:571-580 https://doi.org/10.1016/j.jff.2014.08.017 kostenfrei https://doaj.org/article/8f9b10d5dfe7440ab84e0dae52536093 kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461400276X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2014 571-580
allfields_unstemmed	10.1016/j.jff.2014.08.017 doi (DE-627)DOAJ054971772 (DE-599)DOAJ8f9b10d5dfe7440ab84e0dae52536093 DE-627 ger DE-627 rakwb eng TX341-641 Yaning Shi verfasserin aut Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste. Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis Nutrition. Foods and food supply Jennifer Kovacs-Nolan verfasserin aut Bo Jiang verfasserin aut Rong Tsao verfasserin aut Yoshinori Mine verfasserin aut In Journal of Functional Foods Elsevier, 2021 11(2014), Seite 571-580 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:11 year:2014 pages:571-580 https://doi.org/10.1016/j.jff.2014.08.017 kostenfrei https://doaj.org/article/8f9b10d5dfe7440ab84e0dae52536093 kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461400276X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2014 571-580
allfieldsGer	10.1016/j.jff.2014.08.017 doi (DE-627)DOAJ054971772 (DE-599)DOAJ8f9b10d5dfe7440ab84e0dae52536093 DE-627 ger DE-627 rakwb eng TX341-641 Yaning Shi verfasserin aut Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste. Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis Nutrition. Foods and food supply Jennifer Kovacs-Nolan verfasserin aut Bo Jiang verfasserin aut Rong Tsao verfasserin aut Yoshinori Mine verfasserin aut In Journal of Functional Foods Elsevier, 2021 11(2014), Seite 571-580 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:11 year:2014 pages:571-580 https://doi.org/10.1016/j.jff.2014.08.017 kostenfrei https://doaj.org/article/8f9b10d5dfe7440ab84e0dae52536093 kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461400276X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2014 571-580
allfieldsSound	10.1016/j.jff.2014.08.017 doi (DE-627)DOAJ054971772 (DE-599)DOAJ8f9b10d5dfe7440ab84e0dae52536093 DE-627 ger DE-627 rakwb eng TX341-641 Yaning Shi verfasserin aut Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste. Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis Nutrition. Foods and food supply Jennifer Kovacs-Nolan verfasserin aut Bo Jiang verfasserin aut Rong Tsao verfasserin aut Yoshinori Mine verfasserin aut In Journal of Functional Foods Elsevier, 2021 11(2014), Seite 571-580 (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:11 year:2014 pages:571-580 https://doi.org/10.1016/j.jff.2014.08.017 kostenfrei https://doaj.org/article/8f9b10d5dfe7440ab84e0dae52536093 kostenfrei http://www.sciencedirect.com/science/article/pii/S175646461400276X kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 11 2014 571-580
language	English
source	In Journal of Functional Foods 11(2014), Seite 571-580 volume:11 year:2014 pages:571-580
sourceStr	In Journal of Functional Foods 11(2014), Seite 571-580 volume:11 year:2014 pages:571-580
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Journal of Functional Foods
authorswithroles_txt_mv	Yaning Shi @@aut@@ Jennifer Kovacs-Nolan @@aut@@ Bo Jiang @@aut@@ Rong Tsao @@aut@@ Yoshinori Mine @@aut@@
publishDateDaySort_date	2014-01-01T00:00:00Z
hierarchy_top_id	587138432
id	DOAJ054971772
language_de	englisch
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callnumber-first	T - Technology
author	Yaning Shi
spellingShingle	Yaning Shi misc TX341-641 misc Eggshell membrane hydrolysate misc Oxidative stress misc Lipid peroxidation misc Protein oxidation misc Antioxidant enzyme misc Glutathione synthesis misc Nutrition. Foods and food supply Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells
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topic_title	TX341-641 Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells Eggshell membrane hydrolysate Oxidative stress Lipid peroxidation Protein oxidation Antioxidant enzyme Glutathione synthesis
topic	misc TX341-641 misc Eggshell membrane hydrolysate misc Oxidative stress misc Lipid peroxidation misc Protein oxidation misc Antioxidant enzyme misc Glutathione synthesis misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Eggshell membrane hydrolysate misc Oxidative stress misc Lipid peroxidation misc Protein oxidation misc Antioxidant enzyme misc Glutathione synthesis misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc Eggshell membrane hydrolysate misc Oxidative stress misc Lipid peroxidation misc Protein oxidation misc Antioxidant enzyme misc Glutathione synthesis misc Nutrition. Foods and food supply
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title	Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells
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title_full	Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells
author_sort	Yaning Shi
journal	Journal of Functional Foods
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title_sort	peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in caco-2 cells
callnumber	TX341-641
title_auth	Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells
abstract	Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste.
abstractGer	Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste.
abstract_unstemmed	Excess reactive oxygen species (ROS) cause oxidative stress that is associated with the development of oxidative damage and chronic inflammation. The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. This study confirms that ESM peptides are able to reduce intestinal oxidative stress and thus validates their use as a valuable source material of ESM waste.
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title_short	Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells
url	https://doi.org/10.1016/j.jff.2014.08.017 https://doaj.org/article/8f9b10d5dfe7440ab84e0dae52536093 http://www.sciencedirect.com/science/article/pii/S175646461400276X https://doaj.org/toc/1756-4646
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up_date	2024-07-04T01:18:52.097Z
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The objective of this study was to evaluate the bioactivity of eggshell membrane (ESM) peptides digested with Alcalase and Protease S (AL-PS) at the cellular level. Effects were tested for inhibition of lipid and protein oxidation, synthesis of glutathione (GSH), and cellular antioxidant enzyme activity in H2O2-stimulated Caco-2 cells. AL-PS and its ultrafiltered fraction AL-PS-I (MWCO < 5 kDa) significantly suppressed the formation of H2O2-induced malondialdehyde (MDA) and protein carbonyl derivatives. AL-PS and AL-PS-I also increased glutathione peroxidase (GPx), glutathione S transferase (GST), and glutathione reductase (GR) activity. The peptides also elevated cellular GSH levels via up-regulation of γ-glutamylcysteine synthetase (γ-GCS) activity and its mRNA expression. 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Peptides derived from eggshell membrane improve antioxidant enzyme activity and glutathione synthesis against oxidative damage in Caco-2 cells

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