Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity

In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compat...
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Autor*in:	Primali Rukmal Jayasooriya [verfasserIn] Lindumini Nayanahari Madawalagamage [verfasserIn] Balapuwaduge Ranjit Rigorbert Nihal Mendis [verfasserIn] Tommaso Lombardi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Oral cavity Oral mucosa Head and neck Synovial sarcoma Diagnosis

Übergeordnetes Werk:	In: Dermatopathology - MDPI AG, 2016, 3(2016), 1, Seite 13-22
Übergeordnetes Werk:	volume:3 ; year:2016 ; number:1 ; pages:13-22

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1159/000444876

Katalog-ID:	DOAJ054982952

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topic_facet	Oral cavity Oral mucosa Head and neck Synovial sarcoma Diagnosis Dermatology
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container_title	Dermatopathology
authorswithroles_txt_mv	Primali Rukmal Jayasooriya @@aut@@ Lindumini Nayanahari Madawalagamage @@aut@@ Balapuwaduge Ranjit Rigorbert Nihal Mendis @@aut@@ Tommaso Lombardi @@aut@@
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callnumber-first	R - Medicine
author	Primali Rukmal Jayasooriya
spellingShingle	Primali Rukmal Jayasooriya misc RL1-803 misc Oral cavity misc Oral mucosa misc Head and neck misc Synovial sarcoma misc Diagnosis misc Dermatology Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
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topic_title	RL1-803 Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity Oral cavity Oral mucosa Head and neck Synovial sarcoma Diagnosis
topic	misc RL1-803 misc Oral cavity misc Oral mucosa misc Head and neck misc Synovial sarcoma misc Diagnosis misc Dermatology
topic_unstemmed	misc RL1-803 misc Oral cavity misc Oral mucosa misc Head and neck misc Synovial sarcoma misc Diagnosis misc Dermatology
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title	Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
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title_full	Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
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author_browse	Primali Rukmal Jayasooriya Lindumini Nayanahari Madawalagamage Balapuwaduge Ranjit Rigorbert Nihal Mendis Tommaso Lombardi
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title_sort	diagnostic approach to synovial sarcoma of the head and neck illustrated by two cases arising in the face and oral cavity
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title_auth	Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
abstract	In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compatible with the literature. Histopathologically, both tumours presented as unencapsulated spindle cell tumours arranged into short fascicles. Although the chromosomal translocation of t(X;18)(p11.2;q11.2), transducin-like enhancer of split 1 (TLE-1) and SMARCB1 antibodies derived from gene expression studies are considered as the most sensitive makers to diagnose SS, these facilities were not available. Therefore, our cases were diagnosed as monophasic fibrous SS, utilizing a panel of immunohistochemical markers, including cytokeratins, EMA, Bcl-2, and CD99 as positive indicators and CD34, SMA, MYO-D, and S-100 as negative indicators. PAS staining was used to identify glycogen and to exclude spindle cell carcinomas and leiomyosarcoma, while Alcian blue was used to identify myxoid ground substance and to exclude nodular fasciitis. In conclusion, SS, although rare, should be included in the differential diagnosis of spindle cell tumours of the face and oral mucosa.
abstractGer	In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compatible with the literature. Histopathologically, both tumours presented as unencapsulated spindle cell tumours arranged into short fascicles. Although the chromosomal translocation of t(X;18)(p11.2;q11.2), transducin-like enhancer of split 1 (TLE-1) and SMARCB1 antibodies derived from gene expression studies are considered as the most sensitive makers to diagnose SS, these facilities were not available. Therefore, our cases were diagnosed as monophasic fibrous SS, utilizing a panel of immunohistochemical markers, including cytokeratins, EMA, Bcl-2, and CD99 as positive indicators and CD34, SMA, MYO-D, and S-100 as negative indicators. PAS staining was used to identify glycogen and to exclude spindle cell carcinomas and leiomyosarcoma, while Alcian blue was used to identify myxoid ground substance and to exclude nodular fasciitis. In conclusion, SS, although rare, should be included in the differential diagnosis of spindle cell tumours of the face and oral mucosa.
abstract_unstemmed	In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compatible with the literature. Histopathologically, both tumours presented as unencapsulated spindle cell tumours arranged into short fascicles. Although the chromosomal translocation of t(X;18)(p11.2;q11.2), transducin-like enhancer of split 1 (TLE-1) and SMARCB1 antibodies derived from gene expression studies are considered as the most sensitive makers to diagnose SS, these facilities were not available. Therefore, our cases were diagnosed as monophasic fibrous SS, utilizing a panel of immunohistochemical markers, including cytokeratins, EMA, Bcl-2, and CD99 as positive indicators and CD34, SMA, MYO-D, and S-100 as negative indicators. PAS staining was used to identify glycogen and to exclude spindle cell carcinomas and leiomyosarcoma, while Alcian blue was used to identify myxoid ground substance and to exclude nodular fasciitis. In conclusion, SS, although rare, should be included in the differential diagnosis of spindle cell tumours of the face and oral mucosa.
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title_short	Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity
url	https://doi.org/10.1159/000444876 https://doaj.org/article/a15fbc65912d464c9fed2d1649893b11 http://www.karger.com/Article/FullText/444876 https://doaj.org/toc/2296-3529
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Diagnostic Approach to Synovial Sarcoma of the Head and Neck Illustrated by Two Cases Arising in the Face and Oral Cavity

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