Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3

Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in g...
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Autor*in:	Liang Liu [verfasserIn] Peng Zhang [verfasserIn] Xuchen Dong [verfasserIn] Haoran Li [verfasserIn] Suwen Li [verfasserIn] Shan Cheng [verfasserIn] Jiaqi Yuan [verfasserIn] Xuejun Yang [verfasserIn] Zhiyuan Qian [verfasserIn] Jun Dong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Cell Death and Disease - Nature Publishing Group, 2010, 12(2021), 6, Seite 12
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:6 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41419-021-03834-1

Katalog-ID:	DOAJ054999987

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520			\|a Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas.
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allfields	10.1038/s41419-021-03834-1 doi (DE-627)DOAJ054999987 (DE-599)DOAJ20935000559b481ba0dd57f8fd0d9abf DE-627 ger DE-627 rakwb eng QH573-671 Liang Liu verfasserin aut Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas. Cytology Peng Zhang verfasserin aut Xuchen Dong verfasserin aut Haoran Li verfasserin aut Suwen Li verfasserin aut Shan Cheng verfasserin aut Jiaqi Yuan verfasserin aut Xuejun Yang verfasserin aut Zhiyuan Qian verfasserin aut Jun Dong verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 12(2021), 6, Seite 12 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:12 year:2021 number:6 pages:12 https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/article/20935000559b481ba0dd57f8fd0d9abf kostenfrei https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 12
spelling	10.1038/s41419-021-03834-1 doi (DE-627)DOAJ054999987 (DE-599)DOAJ20935000559b481ba0dd57f8fd0d9abf DE-627 ger DE-627 rakwb eng QH573-671 Liang Liu verfasserin aut Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas. Cytology Peng Zhang verfasserin aut Xuchen Dong verfasserin aut Haoran Li verfasserin aut Suwen Li verfasserin aut Shan Cheng verfasserin aut Jiaqi Yuan verfasserin aut Xuejun Yang verfasserin aut Zhiyuan Qian verfasserin aut Jun Dong verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 12(2021), 6, Seite 12 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:12 year:2021 number:6 pages:12 https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/article/20935000559b481ba0dd57f8fd0d9abf kostenfrei https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 12
allfields_unstemmed	10.1038/s41419-021-03834-1 doi (DE-627)DOAJ054999987 (DE-599)DOAJ20935000559b481ba0dd57f8fd0d9abf DE-627 ger DE-627 rakwb eng QH573-671 Liang Liu verfasserin aut Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas. Cytology Peng Zhang verfasserin aut Xuchen Dong verfasserin aut Haoran Li verfasserin aut Suwen Li verfasserin aut Shan Cheng verfasserin aut Jiaqi Yuan verfasserin aut Xuejun Yang verfasserin aut Zhiyuan Qian verfasserin aut Jun Dong verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 12(2021), 6, Seite 12 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:12 year:2021 number:6 pages:12 https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/article/20935000559b481ba0dd57f8fd0d9abf kostenfrei https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 12
allfieldsGer	10.1038/s41419-021-03834-1 doi (DE-627)DOAJ054999987 (DE-599)DOAJ20935000559b481ba0dd57f8fd0d9abf DE-627 ger DE-627 rakwb eng QH573-671 Liang Liu verfasserin aut Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas. Cytology Peng Zhang verfasserin aut Xuchen Dong verfasserin aut Haoran Li verfasserin aut Suwen Li verfasserin aut Shan Cheng verfasserin aut Jiaqi Yuan verfasserin aut Xuejun Yang verfasserin aut Zhiyuan Qian verfasserin aut Jun Dong verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 12(2021), 6, Seite 12 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:12 year:2021 number:6 pages:12 https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/article/20935000559b481ba0dd57f8fd0d9abf kostenfrei https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 12
allfieldsSound	10.1038/s41419-021-03834-1 doi (DE-627)DOAJ054999987 (DE-599)DOAJ20935000559b481ba0dd57f8fd0d9abf DE-627 ger DE-627 rakwb eng QH573-671 Liang Liu verfasserin aut Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas. Cytology Peng Zhang verfasserin aut Xuchen Dong verfasserin aut Haoran Li verfasserin aut Suwen Li verfasserin aut Shan Cheng verfasserin aut Jiaqi Yuan verfasserin aut Xuejun Yang verfasserin aut Zhiyuan Qian verfasserin aut Jun Dong verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 12(2021), 6, Seite 12 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:12 year:2021 number:6 pages:12 https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/article/20935000559b481ba0dd57f8fd0d9abf kostenfrei https://doi.org/10.1038/s41419-021-03834-1 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 6 12
language	English
source	In Cell Death and Disease 12(2021), 6, Seite 12 volume:12 year:2021 number:6 pages:12
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authorswithroles_txt_mv	Liang Liu @@aut@@ Peng Zhang @@aut@@ Xuchen Dong @@aut@@ Haoran Li @@aut@@ Suwen Li @@aut@@ Shan Cheng @@aut@@ Jiaqi Yuan @@aut@@ Xuejun Yang @@aut@@ Zhiyuan Qian @@aut@@ Jun Dong @@aut@@
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callnumber-first	Q - Science
author	Liang Liu
spellingShingle	Liang Liu misc QH573-671 misc Cytology Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3
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topic_title	QH573-671 Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3
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title	Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3
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title_full	Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3
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author_browse	Liang Liu Peng Zhang Xuchen Dong Haoran Li Suwen Li Shan Cheng Jiaqi Yuan Xuejun Yang Zhiyuan Qian Jun Dong
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title_sort	circ_0001367 inhibits glioma proliferation, migration and invasion by sponging mir-431 and thus regulating nrxn3
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title_auth	Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3
abstract	Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas.
abstractGer	Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas.
abstract_unstemmed	Abstract Many studies have reported that circular RNAs play a vital role in the malignant progression of human cancers. However, the role and underlying mechanism of circRNAs in the development of gliomas have not been fully clarified. In this study, we found that circ_0001367 was downregulated in glioma tissues and showed a close correlation with glioma patient survival. Functional assays demonstrated that upregulation of circ_0001367 could suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo. Furthermore, bioinformatics analysis, luciferase reporter assay and RNA immunoprecipitation assay indicated that circ_0001367 can serve as a sponge for miR-431 and that miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3). In addition, rescue experiments verified that circ_0001367 could regulate both the expression and function of NRXN3 in a miR-431-dependent manner. In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas.
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title_short	Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3
url	https://doi.org/10.1038/s41419-021-03834-1 https://doaj.org/article/20935000559b481ba0dd57f8fd0d9abf https://doaj.org/toc/2041-4889
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