The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats
Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jung Hee Lee [verfasserIn] Yun Kyu Lee [verfasserIn] Hyun-Jong Lee [verfasserIn] Jae Soo Kim [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Koreanisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Acupuncture Research - E-Tree Publishing, 2019, 38(2021), 2, Seite 140-145 |
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| Übergeordnetes Werk: |
volume:38 ; year:2021 ; number:2 ; pages:140-145 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.13045/jar.2020.00409 |
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| Katalog-ID: |
DOAJ055132103 |
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| 520 | |a Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. | ||
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10.13045/jar.2020.00409 doi (DE-627)DOAJ055132103 (DE-599)DOAJ2327dd01e963418087e03eb63ff6e135 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Jung Hee Lee verfasserin aut The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. aconitum sinomontanum nakai pharmacopuncture analgesic effect pain control Miscellaneous systems and treatments Therapeutics. Pharmacology Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 2, Seite 140-145 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:2 pages:140-145 https://doi.org/10.13045/jar.2020.00409 kostenfrei https://doaj.org/article/2327dd01e963418087e03eb63ff6e135 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00409.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 2 140-145 |
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10.13045/jar.2020.00409 doi (DE-627)DOAJ055132103 (DE-599)DOAJ2327dd01e963418087e03eb63ff6e135 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Jung Hee Lee verfasserin aut The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. aconitum sinomontanum nakai pharmacopuncture analgesic effect pain control Miscellaneous systems and treatments Therapeutics. Pharmacology Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 2, Seite 140-145 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:2 pages:140-145 https://doi.org/10.13045/jar.2020.00409 kostenfrei https://doaj.org/article/2327dd01e963418087e03eb63ff6e135 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00409.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 2 140-145 |
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10.13045/jar.2020.00409 doi (DE-627)DOAJ055132103 (DE-599)DOAJ2327dd01e963418087e03eb63ff6e135 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Jung Hee Lee verfasserin aut The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. aconitum sinomontanum nakai pharmacopuncture analgesic effect pain control Miscellaneous systems and treatments Therapeutics. Pharmacology Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 2, Seite 140-145 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:2 pages:140-145 https://doi.org/10.13045/jar.2020.00409 kostenfrei https://doaj.org/article/2327dd01e963418087e03eb63ff6e135 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00409.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 2 140-145 |
| allfieldsGer |
10.13045/jar.2020.00409 doi (DE-627)DOAJ055132103 (DE-599)DOAJ2327dd01e963418087e03eb63ff6e135 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Jung Hee Lee verfasserin aut The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. aconitum sinomontanum nakai pharmacopuncture analgesic effect pain control Miscellaneous systems and treatments Therapeutics. Pharmacology Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 2, Seite 140-145 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:2 pages:140-145 https://doi.org/10.13045/jar.2020.00409 kostenfrei https://doaj.org/article/2327dd01e963418087e03eb63ff6e135 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00409.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 2 140-145 |
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10.13045/jar.2020.00409 doi (DE-627)DOAJ055132103 (DE-599)DOAJ2327dd01e963418087e03eb63ff6e135 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Jung Hee Lee verfasserin aut The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. aconitum sinomontanum nakai pharmacopuncture analgesic effect pain control Miscellaneous systems and treatments Therapeutics. Pharmacology Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 2, Seite 140-145 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:2 pages:140-145 https://doi.org/10.13045/jar.2020.00409 kostenfrei https://doaj.org/article/2327dd01e963418087e03eb63ff6e135 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00409.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 2 140-145 |
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In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). 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Jung Hee Lee |
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RZ409.7-999 RM1-950 The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats aconitum sinomontanum nakai pharmacopuncture analgesic effect pain control |
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The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats |
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The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats |
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Jung Hee Lee |
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Jung Hee Lee Yun Kyu Lee Hyun-Jong Lee Jae Soo Kim |
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analgesic effect of aconitum sinomontanum nakai pharmacopuncture in sprague-dawley rats |
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The Analgesic Effect of Aconitum Sinomontanum Nakai Pharmacopuncture in Sprague-Dawley Rats |
| abstract |
Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. |
| abstractGer |
Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. |
| abstract_unstemmed |
Background Aconitum sinomontanum Nakai (ASN) has been reported to have analgesic effects. In this study an animal model of pharmacopuncture using ASN (100–500 mg/kg) was examined. Methods Sprague-Dawley (SD) rats (n = 40) were randomly assigned to ASN-Low (1 mg/mL, 1.8 mL, ASN-L), ASN-Intermediate (5 mg/mL, 1.8 mL, ASN-M), ASN-High (10 mg/mL, 1.8 mL, ASN-H), negative control (0.2 mL normal saline), and positive control (0.2 mL 0.5% lidocaine) groups. All experiments were administered to the rats’ left hind leg. The analgesic response was assessed by monitoring the physical (hot plate, and von Frey test) and chemical (formalin) responses to pain. Results All ASN pharmacopuncture groups demonstrated significant differences in pain response to the hot plate test, von Frey test, and formalin test, compared to the control group (p < 0.05). The response of the ASN-M group and ASN-H groups to the hot plate, the formalin, and the von Frey tests were significantly different, compared to the lidocaine group (p < 0.05). Conclusion ASN pharmacopuncture had a significant analgesic effect on SD rats in response to physical and chemical models of pain. |
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