Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise

This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, appr...
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Autor*in:	Wenyuan G. Zhu [verfasserIn] Jamie E. Hibbert [verfasserIn] Kuan Hung Lin [verfasserIn] Nathaniel D. Steinert [verfasserIn] Jake L. Lemens [verfasserIn] Kent W. Jorgenson [verfasserIn] Sarah M. Newman [verfasserIn] Dudley W. Lamming [verfasserIn] Troy A. Hornberger [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	skeletal muscle hypertrophy myonuclear accretion protein synthesis signaling growth

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 10(2021), 9, p 2459
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:9, p 2459

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells10092459

Katalog-ID:	DOAJ055154344

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callnumber-first	Q - Science
author	Wenyuan G. Zhu
spellingShingle	Wenyuan G. Zhu misc QH573-671 misc skeletal muscle misc hypertrophy misc myonuclear accretion misc protein synthesis misc signaling misc growth misc Cytology Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
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topic_title	QH573-671 Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise skeletal muscle hypertrophy myonuclear accretion protein synthesis signaling growth
topic	misc QH573-671 misc skeletal muscle misc hypertrophy misc myonuclear accretion misc protein synthesis misc signaling misc growth misc Cytology
topic_unstemmed	misc QH573-671 misc skeletal muscle misc hypertrophy misc myonuclear accretion misc protein synthesis misc signaling misc growth misc Cytology
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title	Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
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title_full	Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
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author_browse	Wenyuan G. Zhu Jamie E. Hibbert Kuan Hung Lin Nathaniel D. Steinert Jake L. Lemens Kent W. Jorgenson Sarah M. Newman Dudley W. Lamming Troy A. Hornberger
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title_sort	weight pulling: a novel mouse model of human progressive resistance exercise
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title_auth	Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
abstract	This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual’s performance). We demonstrate that weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, we demonstrate that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this study indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise.
abstractGer	This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual’s performance). We demonstrate that weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, we demonstrate that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this study indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise.
abstract_unstemmed	This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual’s performance). We demonstrate that weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, we demonstrate that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this study indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise.
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title_short	Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
url	https://doi.org/10.3390/cells10092459 https://doaj.org/article/a8c60c5da2fe40e0b413a2e752c319a0 https://www.mdpi.com/2073-4409/10/9/2459 https://doaj.org/toc/2073-4409
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