An update on oral drug delivery via intestinal lymphatic transport

Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metab...
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Autor*in:	Zichen Zhang [verfasserIn] Yi Lu [verfasserIn] Jianping Qi [verfasserIn] Wei Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell

Übergeordnetes Werk:	In: Acta Pharmaceutica Sinica B - Elsevier, 2013, 11(2021), 8, Seite 2449-2468
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:8 ; pages:2449-2468

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.apsb.2020.12.022

Katalog-ID:	DOAJ05517616X

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allfieldsSound	10.1016/j.apsb.2020.12.022 doi (DE-627)DOAJ05517616X (DE-599)DOAJ67139eee30734117a7987d4b1ed01707 DE-627 ger DE-627 rakwb eng RM1-950 Zichen Zhang verfasserin aut An update on oral drug delivery via intestinal lymphatic transport 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications. Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell Therapeutics. Pharmacology Yi Lu verfasserin aut Jianping Qi verfasserin aut Wei Wu verfasserin aut In Acta Pharmaceutica Sinica B Elsevier, 2013 11(2021), 8, Seite 2449-2468 (DE-627)670211095 (DE-600)2631779-5 22113843 nnns volume:11 year:2021 number:8 pages:2449-2468 https://doi.org/10.1016/j.apsb.2020.12.022 kostenfrei https://doaj.org/article/67139eee30734117a7987d4b1ed01707 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211383521000344 kostenfrei https://doaj.org/toc/2211-3835 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 8 2449-2468
language	English
source	In Acta Pharmaceutica Sinica B 11(2021), 8, Seite 2449-2468 volume:11 year:2021 number:8 pages:2449-2468
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institution	findex.gbv.de
topic_facet	Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell Therapeutics. Pharmacology
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container_title	Acta Pharmaceutica Sinica B
authorswithroles_txt_mv	Zichen Zhang @@aut@@ Yi Lu @@aut@@ Jianping Qi @@aut@@ Wei Wu @@aut@@
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callnumber-first	R - Medicine
author	Zichen Zhang
spellingShingle	Zichen Zhang misc RM1-950 misc Drug delivery misc Oral misc Lymphatic transport misc Drug absorption misc Chylomicron misc Microfold cell misc Therapeutics. Pharmacology An update on oral drug delivery via intestinal lymphatic transport
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topic_title	RM1-950 An update on oral drug delivery via intestinal lymphatic transport Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell
topic	misc RM1-950 misc Drug delivery misc Oral misc Lymphatic transport misc Drug absorption misc Chylomicron misc Microfold cell misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Drug delivery misc Oral misc Lymphatic transport misc Drug absorption misc Chylomicron misc Microfold cell misc Therapeutics. Pharmacology
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title	An update on oral drug delivery via intestinal lymphatic transport
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title_full	An update on oral drug delivery via intestinal lymphatic transport
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title_sort	update on oral drug delivery via intestinal lymphatic transport
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title_auth	An update on oral drug delivery via intestinal lymphatic transport
abstract	Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.
abstractGer	Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.
abstract_unstemmed	Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.
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title_short	An update on oral drug delivery via intestinal lymphatic transport
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An update on oral drug delivery via intestinal lymphatic transport

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Zugang & Verfügbarkeit

Vorhandene Bände

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