Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice

This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowere...
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Gespeichert in:

Autor*in:	Lingzhi Li [verfasserIn] Zhifeng Fang [verfasserIn] Zongmin Liu [verfasserIn] Jianxin Zhao [verfasserIn] Hao Zhang [verfasserIn] Shunyu Wang [verfasserIn] Jianxin He [verfasserIn] Wenwei Lu [verfasserIn] Wei Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Allergic asthma Lactobacillus reuteri Treg cells Propionate Gut microbiota

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 76(2021), Seite 104286-
Übergeordnetes Werk:	volume:76 ; year:2021 ; pages:104286-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2020.104286

Katalog-ID:	DOAJ055222447

Internformat


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245	1	0	\|a Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice
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520			\|a This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation.
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publishDate	2021
allfields	10.1016/j.jff.2020.104286 doi (DE-627)DOAJ055222447 (DE-599)DOAJ216d356299ab4adba51856e41f05c2d3 DE-627 ger DE-627 rakwb eng TX341-641 Lingzhi Li verfasserin aut Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation. Allergic asthma Lactobacillus reuteri Treg cells Propionate Gut microbiota Nutrition. Foods and food supply Zhifeng Fang verfasserin aut Zongmin Liu verfasserin aut Jianxin Zhao verfasserin aut Hao Zhang verfasserin aut Shunyu Wang verfasserin aut Jianxin He verfasserin aut Wenwei Lu verfasserin aut Wei Chen verfasserin aut In Journal of Functional Foods Elsevier, 2021 76(2021), Seite 104286- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:76 year:2021 pages:104286- https://doi.org/10.1016/j.jff.2020.104286 kostenfrei https://doaj.org/article/216d356299ab4adba51856e41f05c2d3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464620305107 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 76 2021 104286-
spelling	10.1016/j.jff.2020.104286 doi (DE-627)DOAJ055222447 (DE-599)DOAJ216d356299ab4adba51856e41f05c2d3 DE-627 ger DE-627 rakwb eng TX341-641 Lingzhi Li verfasserin aut Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation. Allergic asthma Lactobacillus reuteri Treg cells Propionate Gut microbiota Nutrition. Foods and food supply Zhifeng Fang verfasserin aut Zongmin Liu verfasserin aut Jianxin Zhao verfasserin aut Hao Zhang verfasserin aut Shunyu Wang verfasserin aut Jianxin He verfasserin aut Wenwei Lu verfasserin aut Wei Chen verfasserin aut In Journal of Functional Foods Elsevier, 2021 76(2021), Seite 104286- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:76 year:2021 pages:104286- https://doi.org/10.1016/j.jff.2020.104286 kostenfrei https://doaj.org/article/216d356299ab4adba51856e41f05c2d3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464620305107 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 76 2021 104286-
allfields_unstemmed	10.1016/j.jff.2020.104286 doi (DE-627)DOAJ055222447 (DE-599)DOAJ216d356299ab4adba51856e41f05c2d3 DE-627 ger DE-627 rakwb eng TX341-641 Lingzhi Li verfasserin aut Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation. Allergic asthma Lactobacillus reuteri Treg cells Propionate Gut microbiota Nutrition. Foods and food supply Zhifeng Fang verfasserin aut Zongmin Liu verfasserin aut Jianxin Zhao verfasserin aut Hao Zhang verfasserin aut Shunyu Wang verfasserin aut Jianxin He verfasserin aut Wenwei Lu verfasserin aut Wei Chen verfasserin aut In Journal of Functional Foods Elsevier, 2021 76(2021), Seite 104286- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:76 year:2021 pages:104286- https://doi.org/10.1016/j.jff.2020.104286 kostenfrei https://doaj.org/article/216d356299ab4adba51856e41f05c2d3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464620305107 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 76 2021 104286-
allfieldsGer	10.1016/j.jff.2020.104286 doi (DE-627)DOAJ055222447 (DE-599)DOAJ216d356299ab4adba51856e41f05c2d3 DE-627 ger DE-627 rakwb eng TX341-641 Lingzhi Li verfasserin aut Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation. Allergic asthma Lactobacillus reuteri Treg cells Propionate Gut microbiota Nutrition. Foods and food supply Zhifeng Fang verfasserin aut Zongmin Liu verfasserin aut Jianxin Zhao verfasserin aut Hao Zhang verfasserin aut Shunyu Wang verfasserin aut Jianxin He verfasserin aut Wenwei Lu verfasserin aut Wei Chen verfasserin aut In Journal of Functional Foods Elsevier, 2021 76(2021), Seite 104286- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:76 year:2021 pages:104286- https://doi.org/10.1016/j.jff.2020.104286 kostenfrei https://doaj.org/article/216d356299ab4adba51856e41f05c2d3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464620305107 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 76 2021 104286-
allfieldsSound	10.1016/j.jff.2020.104286 doi (DE-627)DOAJ055222447 (DE-599)DOAJ216d356299ab4adba51856e41f05c2d3 DE-627 ger DE-627 rakwb eng TX341-641 Lingzhi Li verfasserin aut Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation. Allergic asthma Lactobacillus reuteri Treg cells Propionate Gut microbiota Nutrition. Foods and food supply Zhifeng Fang verfasserin aut Zongmin Liu verfasserin aut Jianxin Zhao verfasserin aut Hao Zhang verfasserin aut Shunyu Wang verfasserin aut Jianxin He verfasserin aut Wenwei Lu verfasserin aut Wei Chen verfasserin aut In Journal of Functional Foods Elsevier, 2021 76(2021), Seite 104286- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:76 year:2021 pages:104286- https://doi.org/10.1016/j.jff.2020.104286 kostenfrei https://doaj.org/article/216d356299ab4adba51856e41f05c2d3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464620305107 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 76 2021 104286-
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topic_title	TX341-641 Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice Allergic asthma Lactobacillus reuteri Treg cells Propionate Gut microbiota
topic	misc TX341-641 misc Allergic asthma misc Lactobacillus reuteri misc Treg cells misc Propionate misc Gut microbiota misc Nutrition. Foods and food supply
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title_auth	Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice
abstract	This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation.
abstractGer	This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation.
abstract_unstemmed	This study investigated the effects of Lactobacillus (L.) reuteri strains on airway inflammation, immune responses, and gut microbiota in a house dust mite (HDM)-induced allergic asthma murine model. The L. reuteri strains CCFM1072 and CCFM1040, which increased Treg populations in the spleen, lowered airway inflammation as compared to other strains, downregulated histamine, IL-17A, IL-5, and IL-13 levels in the lungs, and reduced Th2-related immunoglobulin concentrations in serum. Gut microbiota and metabolism analysis revealed that CCFM1072 maintained the diversity of the gut microbiota, promoted the growth of L. reuteri and Bacteroides thetaiotaomicron, and increased propionate levels, whereas CCFM1040 remodeled the structure of the gut microbiota, particularly promoting the growth of Bifidobacterium, and these promoted bacteria were linked to the improvement of airway inflammation. In summary, the two L. reuteri strains have effects on alleviating airway inflammation partly depending on modulating gut microbiota, albeit differently, and promoting Tregs proliferation.
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title_short	Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice
url	https://doi.org/10.1016/j.jff.2020.104286 https://doaj.org/article/216d356299ab4adba51856e41f05c2d3 http://www.sciencedirect.com/science/article/pii/S1756464620305107 https://doaj.org/toc/1756-4646
remote_bool	true
author2	Zhifeng Fang Zongmin Liu Jianxin Zhao Hao Zhang Shunyu Wang Jianxin He Wenwei Lu Wei Chen
author2Str	Zhifeng Fang Zongmin Liu Jianxin Zhao Hao Zhang Shunyu Wang Jianxin He Wenwei Lu Wei Chen
ppnlink	587138432
callnumber-subject	TX - Home Economics
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isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1016/j.jff.2020.104286
callnumber-a	TX341-641
up_date	2024-07-03T13:42:32.266Z
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Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice

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