Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells
Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferat...
Ausführliche Beschreibung
Autor*in: |
Saki Onuma [verfasserIn] Aya Manabe [verfasserIn] Yuta Yoshino [verfasserIn] Toshiyuki Matsunaga [verfasserIn] Tomohiro Asai [verfasserIn] Akira Ikari [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Cells - MDPI AG, 2012, 10(2021), 5, p 1179 |
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Übergeordnetes Werk: |
volume:10 ; year:2021 ; number:5, p 1179 |
Links: |
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DOI / URN: |
10.3390/cells10051179 |
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Katalog-ID: |
DOAJ055486711 |
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10.3390/cells10051179 doi (DE-627)DOAJ055486711 (DE-599)DOAJ8a547cd278e64ec49c5c85f53e5083d4 DE-627 ger DE-627 rakwb eng QH573-671 Saki Onuma verfasserin aut Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. lung adenocarcinoma chemoresistance ABCB1 hypomagnesemia Cytology Aya Manabe verfasserin aut Yuta Yoshino verfasserin aut Toshiyuki Matsunaga verfasserin aut Tomohiro Asai verfasserin aut Akira Ikari verfasserin aut In Cells MDPI AG, 2012 10(2021), 5, p 1179 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:5, p 1179 https://doi.org/10.3390/cells10051179 kostenfrei https://doaj.org/article/8a547cd278e64ec49c5c85f53e5083d4 kostenfrei https://www.mdpi.com/2073-4409/10/5/1179 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 5, p 1179 |
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10.3390/cells10051179 doi (DE-627)DOAJ055486711 (DE-599)DOAJ8a547cd278e64ec49c5c85f53e5083d4 DE-627 ger DE-627 rakwb eng QH573-671 Saki Onuma verfasserin aut Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. lung adenocarcinoma chemoresistance ABCB1 hypomagnesemia Cytology Aya Manabe verfasserin aut Yuta Yoshino verfasserin aut Toshiyuki Matsunaga verfasserin aut Tomohiro Asai verfasserin aut Akira Ikari verfasserin aut In Cells MDPI AG, 2012 10(2021), 5, p 1179 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:5, p 1179 https://doi.org/10.3390/cells10051179 kostenfrei https://doaj.org/article/8a547cd278e64ec49c5c85f53e5083d4 kostenfrei https://www.mdpi.com/2073-4409/10/5/1179 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 5, p 1179 |
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10.3390/cells10051179 doi (DE-627)DOAJ055486711 (DE-599)DOAJ8a547cd278e64ec49c5c85f53e5083d4 DE-627 ger DE-627 rakwb eng QH573-671 Saki Onuma verfasserin aut Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. lung adenocarcinoma chemoresistance ABCB1 hypomagnesemia Cytology Aya Manabe verfasserin aut Yuta Yoshino verfasserin aut Toshiyuki Matsunaga verfasserin aut Tomohiro Asai verfasserin aut Akira Ikari verfasserin aut In Cells MDPI AG, 2012 10(2021), 5, p 1179 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:5, p 1179 https://doi.org/10.3390/cells10051179 kostenfrei https://doaj.org/article/8a547cd278e64ec49c5c85f53e5083d4 kostenfrei https://www.mdpi.com/2073-4409/10/5/1179 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 5, p 1179 |
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10.3390/cells10051179 doi (DE-627)DOAJ055486711 (DE-599)DOAJ8a547cd278e64ec49c5c85f53e5083d4 DE-627 ger DE-627 rakwb eng QH573-671 Saki Onuma verfasserin aut Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. lung adenocarcinoma chemoresistance ABCB1 hypomagnesemia Cytology Aya Manabe verfasserin aut Yuta Yoshino verfasserin aut Toshiyuki Matsunaga verfasserin aut Tomohiro Asai verfasserin aut Akira Ikari verfasserin aut In Cells MDPI AG, 2012 10(2021), 5, p 1179 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:5, p 1179 https://doi.org/10.3390/cells10051179 kostenfrei https://doaj.org/article/8a547cd278e64ec49c5c85f53e5083d4 kostenfrei https://www.mdpi.com/2073-4409/10/5/1179 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 5, p 1179 |
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10.3390/cells10051179 doi (DE-627)DOAJ055486711 (DE-599)DOAJ8a547cd278e64ec49c5c85f53e5083d4 DE-627 ger DE-627 rakwb eng QH573-671 Saki Onuma verfasserin aut Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. lung adenocarcinoma chemoresistance ABCB1 hypomagnesemia Cytology Aya Manabe verfasserin aut Yuta Yoshino verfasserin aut Toshiyuki Matsunaga verfasserin aut Tomohiro Asai verfasserin aut Akira Ikari verfasserin aut In Cells MDPI AG, 2012 10(2021), 5, p 1179 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:5, p 1179 https://doi.org/10.3390/cells10051179 kostenfrei https://doaj.org/article/8a547cd278e64ec49c5c85f53e5083d4 kostenfrei https://www.mdpi.com/2073-4409/10/5/1179 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 5, p 1179 |
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Saki Onuma misc QH573-671 misc lung adenocarcinoma misc chemoresistance misc ABCB1 misc hypomagnesemia misc Cytology Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells |
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QH573-671 Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells lung adenocarcinoma chemoresistance ABCB1 hypomagnesemia |
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Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells |
abstract |
Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. |
abstractGer |
Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. |
abstract_unstemmed |
Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup<2+</sup< deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup<2+</sup< concentration (LM) on proliferation and chemosensitivity using human lung adenocarcinoma A549 cells. Cell proliferation was reduced by continuous culture with LM accompanied with the elevation of G1 phase proportion. The amounts of reactive oxygen species (ROS) and stress makers such as phosphorylated-ataxia telangiectasia mutated and phosphorylated-p53 were increased by LM. Cell injury was dose-dependently increased by anticancer drugs such as CDDP and doxorubicin (DXR), which were suppressed by LM. Similar results were obtained by roscovitine, a cell cycle inhibitor. These results suggest that LM induces chemoresistance mediated by ROS production and G1 arrest. The mRNA and protein levels of ATP binding cassette subfamily B member 1 (ABCB1) were increased by LM and roscovitine. The LM-induced elevation of ABCB1 and nuclear p38 expression was suppressed by SB203580, a p38 MAPK inhibitor. PSC833, an ABCB1 inhibitor, and SB203580 rescued the sensitivity to anticancer drugs. In addition, cancer stemness properties were suppressed by SB203580. We suggest that Mg<sup<2+</sup< deficiency reduces the chemotherapy sensitivity of A549 cells, although it suppresses cell proliferation. |
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Upregulation of Chemoresistance by Mg<sup<2+</sup< Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells |
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