Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat

We aimed to identify mechanisms by which apolipoprotein B-48 (apoB-48) could have an atherogenic role by simultaneously studying the metabolism of postprandial apoB-48 and apoB-100 lipoproteins. The kinetics of apoB-48 and apoB-100, each in four density subfractions of VLDL and intermediate density...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chunyu Zheng [verfasserIn] Katsunori Ikewaki [verfasserIn] Brian W. Walsh [verfasserIn] Frank M. Sacks [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2006

Schlagwörter:	kinetics stable isotopes triglyceride-rich lipoproteins apolipoprotein B-48 apolipoprotein B-100

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 47(2006), 8, Seite 1771-1779
Übergeordnetes Werk:	volume:47 ; year:2006 ; number:8 ; pages:1771-1779

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M500528-JLR200

Katalog-ID:	DOAJ05551510X

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520			\|a We aimed to identify mechanisms by which apolipoprotein B-48 (apoB-48) could have an atherogenic role by simultaneously studying the metabolism of postprandial apoB-48 and apoB-100 lipoproteins. The kinetics of apoB-48 and apoB-100, each in four density subfractions of VLDL and intermediate density lipoprotein (IDL), were studied by stable isotope labeling in a constantly fed state with half-hourly administration of almond oil in five postmenopausal women. A non-steady-state, multicompartmental model was used. Despite a much lower production rate, VLDL and IDL apoB-48 shared a similar secretion pattern with apoB-100: both were directly secreted into all fractions with similar percentage mass distributions. Fractional catabolic rates (FCRs) of apoB-48 and apoB-100 were similar in VLDL and IDL. We identified a fast turnover compartment of light VLDL that had a residence time of <30 min for apoB-48 and apoB-100. Finally, a high secretion rate of apoB-48 was associated with a slow FCR of VLDL and IDL apoB-100. In conclusion, the intestine secretes a spectrum of apoB lipoproteins, similar to what the liver secretes, albeit with a much lower secretion rate. Once in plasma, intestinal and hepatic triglyceride-rich lipoproteins have similar rates of clearance and participate interactively in similar metabolic pathways, with high apoB-48 production inhibiting the clearance of apoB-100.
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allfields	10.1194/jlr.M500528-JLR200 doi (DE-627)DOAJ05551510X (DE-599)DOAJb2f59745a64a44ae8c15738554548679 DE-627 ger DE-627 rakwb eng QD415-436 Chunyu Zheng verfasserin aut Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We aimed to identify mechanisms by which apolipoprotein B-48 (apoB-48) could have an atherogenic role by simultaneously studying the metabolism of postprandial apoB-48 and apoB-100 lipoproteins. The kinetics of apoB-48 and apoB-100, each in four density subfractions of VLDL and intermediate density lipoprotein (IDL), were studied by stable isotope labeling in a constantly fed state with half-hourly administration of almond oil in five postmenopausal women. A non-steady-state, multicompartmental model was used. Despite a much lower production rate, VLDL and IDL apoB-48 shared a similar secretion pattern with apoB-100: both were directly secreted into all fractions with similar percentage mass distributions. Fractional catabolic rates (FCRs) of apoB-48 and apoB-100 were similar in VLDL and IDL. We identified a fast turnover compartment of light VLDL that had a residence time of <30 min for apoB-48 and apoB-100. Finally, a high secretion rate of apoB-48 was associated with a slow FCR of VLDL and IDL apoB-100. In conclusion, the intestine secretes a spectrum of apoB lipoproteins, similar to what the liver secretes, albeit with a much lower secretion rate. Once in plasma, intestinal and hepatic triglyceride-rich lipoproteins have similar rates of clearance and participate interactively in similar metabolic pathways, with high apoB-48 production inhibiting the clearance of apoB-100. kinetics stable isotopes triglyceride-rich lipoproteins apolipoprotein B-48 apolipoprotein B-100 Biochemistry Katsunori Ikewaki verfasserin aut Brian W. Walsh verfasserin aut Frank M. Sacks verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 8, Seite 1771-1779 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:8 pages:1771-1779 https://doi.org/10.1194/jlr.M500528-JLR200 kostenfrei https://doaj.org/article/b2f59745a64a44ae8c15738554548679 kostenfrei http://www.sciencedirect.com/science/article/pii/S002222752033162X kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 8 1771-1779
spelling	10.1194/jlr.M500528-JLR200 doi (DE-627)DOAJ05551510X (DE-599)DOAJb2f59745a64a44ae8c15738554548679 DE-627 ger DE-627 rakwb eng QD415-436 Chunyu Zheng verfasserin aut Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We aimed to identify mechanisms by which apolipoprotein B-48 (apoB-48) could have an atherogenic role by simultaneously studying the metabolism of postprandial apoB-48 and apoB-100 lipoproteins. The kinetics of apoB-48 and apoB-100, each in four density subfractions of VLDL and intermediate density lipoprotein (IDL), were studied by stable isotope labeling in a constantly fed state with half-hourly administration of almond oil in five postmenopausal women. A non-steady-state, multicompartmental model was used. Despite a much lower production rate, VLDL and IDL apoB-48 shared a similar secretion pattern with apoB-100: both were directly secreted into all fractions with similar percentage mass distributions. Fractional catabolic rates (FCRs) of apoB-48 and apoB-100 were similar in VLDL and IDL. We identified a fast turnover compartment of light VLDL that had a residence time of <30 min for apoB-48 and apoB-100. Finally, a high secretion rate of apoB-48 was associated with a slow FCR of VLDL and IDL apoB-100. In conclusion, the intestine secretes a spectrum of apoB lipoproteins, similar to what the liver secretes, albeit with a much lower secretion rate. Once in plasma, intestinal and hepatic triglyceride-rich lipoproteins have similar rates of clearance and participate interactively in similar metabolic pathways, with high apoB-48 production inhibiting the clearance of apoB-100. kinetics stable isotopes triglyceride-rich lipoproteins apolipoprotein B-48 apolipoprotein B-100 Biochemistry Katsunori Ikewaki verfasserin aut Brian W. Walsh verfasserin aut Frank M. Sacks verfasserin aut In Journal of Lipid Research Elsevier, 2021 47(2006), 8, Seite 1771-1779 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:47 year:2006 number:8 pages:1771-1779 https://doi.org/10.1194/jlr.M500528-JLR200 kostenfrei https://doaj.org/article/b2f59745a64a44ae8c15738554548679 kostenfrei http://www.sciencedirect.com/science/article/pii/S002222752033162X kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2006 8 1771-1779
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topic_facet	kinetics stable isotopes triglyceride-rich lipoproteins apolipoprotein B-48 apolipoprotein B-100 Biochemistry
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authorswithroles_txt_mv	Chunyu Zheng @@aut@@ Katsunori Ikewaki @@aut@@ Brian W. Walsh @@aut@@ Frank M. Sacks @@aut@@
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callnumber-first	Q - Science
author	Chunyu Zheng
spellingShingle	Chunyu Zheng misc QD415-436 misc kinetics misc stable isotopes misc triglyceride-rich lipoproteins misc apolipoprotein B-48 misc apolipoprotein B-100 misc Biochemistry Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat
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topic_title	QD415-436 Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat kinetics stable isotopes triglyceride-rich lipoproteins apolipoprotein B-48 apolipoprotein B-100
topic	misc QD415-436 misc kinetics misc stable isotopes misc triglyceride-rich lipoproteins misc apolipoprotein B-48 misc apolipoprotein B-100 misc Biochemistry
topic_unstemmed	misc QD415-436 misc kinetics misc stable isotopes misc triglyceride-rich lipoproteins misc apolipoprotein B-48 misc apolipoprotein B-100 misc Biochemistry
topic_browse	misc QD415-436 misc kinetics misc stable isotopes misc triglyceride-rich lipoproteins misc apolipoprotein B-48 misc apolipoprotein B-100 misc Biochemistry
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title	Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat
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title_full	Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat
author_sort	Chunyu Zheng
journal	Journal of Lipid Research
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author_browse	Chunyu Zheng Katsunori Ikewaki Brian W. Walsh Frank M. Sacks
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title_sort	metabolism of apob lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat
callnumber	QD415-436
title_auth	Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat
abstract	We aimed to identify mechanisms by which apolipoprotein B-48 (apoB-48) could have an atherogenic role by simultaneously studying the metabolism of postprandial apoB-48 and apoB-100 lipoproteins. The kinetics of apoB-48 and apoB-100, each in four density subfractions of VLDL and intermediate density lipoprotein (IDL), were studied by stable isotope labeling in a constantly fed state with half-hourly administration of almond oil in five postmenopausal women. A non-steady-state, multicompartmental model was used. Despite a much lower production rate, VLDL and IDL apoB-48 shared a similar secretion pattern with apoB-100: both were directly secreted into all fractions with similar percentage mass distributions. Fractional catabolic rates (FCRs) of apoB-48 and apoB-100 were similar in VLDL and IDL. We identified a fast turnover compartment of light VLDL that had a residence time of <30 min for apoB-48 and apoB-100. Finally, a high secretion rate of apoB-48 was associated with a slow FCR of VLDL and IDL apoB-100. In conclusion, the intestine secretes a spectrum of apoB lipoproteins, similar to what the liver secretes, albeit with a much lower secretion rate. Once in plasma, intestinal and hepatic triglyceride-rich lipoproteins have similar rates of clearance and participate interactively in similar metabolic pathways, with high apoB-48 production inhibiting the clearance of apoB-100.
abstractGer	We aimed to identify mechanisms by which apolipoprotein B-48 (apoB-48) could have an atherogenic role by simultaneously studying the metabolism of postprandial apoB-48 and apoB-100 lipoproteins. The kinetics of apoB-48 and apoB-100, each in four density subfractions of VLDL and intermediate density lipoprotein (IDL), were studied by stable isotope labeling in a constantly fed state with half-hourly administration of almond oil in five postmenopausal women. A non-steady-state, multicompartmental model was used. Despite a much lower production rate, VLDL and IDL apoB-48 shared a similar secretion pattern with apoB-100: both were directly secreted into all fractions with similar percentage mass distributions. Fractional catabolic rates (FCRs) of apoB-48 and apoB-100 were similar in VLDL and IDL. We identified a fast turnover compartment of light VLDL that had a residence time of <30 min for apoB-48 and apoB-100. Finally, a high secretion rate of apoB-48 was associated with a slow FCR of VLDL and IDL apoB-100. In conclusion, the intestine secretes a spectrum of apoB lipoproteins, similar to what the liver secretes, albeit with a much lower secretion rate. Once in plasma, intestinal and hepatic triglyceride-rich lipoproteins have similar rates of clearance and participate interactively in similar metabolic pathways, with high apoB-48 production inhibiting the clearance of apoB-100.
abstract_unstemmed	We aimed to identify mechanisms by which apolipoprotein B-48 (apoB-48) could have an atherogenic role by simultaneously studying the metabolism of postprandial apoB-48 and apoB-100 lipoproteins. The kinetics of apoB-48 and apoB-100, each in four density subfractions of VLDL and intermediate density lipoprotein (IDL), were studied by stable isotope labeling in a constantly fed state with half-hourly administration of almond oil in five postmenopausal women. A non-steady-state, multicompartmental model was used. Despite a much lower production rate, VLDL and IDL apoB-48 shared a similar secretion pattern with apoB-100: both were directly secreted into all fractions with similar percentage mass distributions. Fractional catabolic rates (FCRs) of apoB-48 and apoB-100 were similar in VLDL and IDL. We identified a fast turnover compartment of light VLDL that had a residence time of <30 min for apoB-48 and apoB-100. Finally, a high secretion rate of apoB-48 was associated with a slow FCR of VLDL and IDL apoB-100. In conclusion, the intestine secretes a spectrum of apoB lipoproteins, similar to what the liver secretes, albeit with a much lower secretion rate. Once in plasma, intestinal and hepatic triglyceride-rich lipoproteins have similar rates of clearance and participate interactively in similar metabolic pathways, with high apoB-48 production inhibiting the clearance of apoB-100.
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title_short	Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat
url	https://doi.org/10.1194/jlr.M500528-JLR200 https://doaj.org/article/b2f59745a64a44ae8c15738554548679 http://www.sciencedirect.com/science/article/pii/S002222752033162X https://doaj.org/toc/0022-2275
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author2	Katsunori Ikewaki Brian W. Walsh Frank M. Sacks
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up_date	2024-07-03T15:26:01.898Z
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Metabolism of apoB lipoproteins of intestinal and hepatic origin during constant feeding of small amounts of fat

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