Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults

Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H...
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Autor*in:	Komei Iwai [verfasserIn] Isao Watanabe [verfasserIn] Toshiro Yamamoto [verfasserIn] Nagato Kuriyama [verfasserIn] Daisuke Matsui [verfasserIn] Ryota Nomura [verfasserIn] Yuko Ogaya [verfasserIn] Fumishige Oseko [verfasserIn] Keiji Adachi [verfasserIn] Shigeta Takizawa [verfasserIn] Etsuko Ozaki [verfasserIn] Teruhide Koyama [verfasserIn] Kazuhiko Nakano [verfasserIn] Narisato Kanamura [verfasserIn] Ritei Uehara [verfasserIn] Yoshiyuki Watanabe [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Helicobacter pylori infection H. pylori Ulcer Gastric cancer Dental pulp Dental caries

Übergeordnetes Werk:	In: BMC Oral Health - BMC, 2003, 19(2019), 1, Seite 8
Übergeordnetes Werk:	volume:19 ; year:2019 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12903-019-0967-2

Katalog-ID:	DOAJ05552219X

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520			\|a Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal.
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allfields	10.1186/s12903-019-0967-2 doi (DE-627)DOAJ05552219X (DE-599)DOAJd4a492ba05a64fc6935f5bf38c798d2e DE-627 ger DE-627 rakwb eng RK1-715 Komei Iwai verfasserin aut Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal. Helicobacter pylori infection H. pylori Ulcer Gastric cancer Dental pulp Dental caries Dentistry Isao Watanabe verfasserin aut Toshiro Yamamoto verfasserin aut Nagato Kuriyama verfasserin aut Daisuke Matsui verfasserin aut Ryota Nomura verfasserin aut Yuko Ogaya verfasserin aut Fumishige Oseko verfasserin aut Keiji Adachi verfasserin aut Shigeta Takizawa verfasserin aut Etsuko Ozaki verfasserin aut Teruhide Koyama verfasserin aut Kazuhiko Nakano verfasserin aut Narisato Kanamura verfasserin aut Ritei Uehara verfasserin aut Yoshiyuki Watanabe verfasserin aut In BMC Oral Health BMC, 2003 19(2019), 1, Seite 8 (DE-627)355500108 (DE-600)2091511-1 14726831 nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/article/d4a492ba05a64fc6935f5bf38c798d2e kostenfrei https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/toc/1472-6831 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
spelling	10.1186/s12903-019-0967-2 doi (DE-627)DOAJ05552219X (DE-599)DOAJd4a492ba05a64fc6935f5bf38c798d2e DE-627 ger DE-627 rakwb eng RK1-715 Komei Iwai verfasserin aut Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal. Helicobacter pylori infection H. pylori Ulcer Gastric cancer Dental pulp Dental caries Dentistry Isao Watanabe verfasserin aut Toshiro Yamamoto verfasserin aut Nagato Kuriyama verfasserin aut Daisuke Matsui verfasserin aut Ryota Nomura verfasserin aut Yuko Ogaya verfasserin aut Fumishige Oseko verfasserin aut Keiji Adachi verfasserin aut Shigeta Takizawa verfasserin aut Etsuko Ozaki verfasserin aut Teruhide Koyama verfasserin aut Kazuhiko Nakano verfasserin aut Narisato Kanamura verfasserin aut Ritei Uehara verfasserin aut Yoshiyuki Watanabe verfasserin aut In BMC Oral Health BMC, 2003 19(2019), 1, Seite 8 (DE-627)355500108 (DE-600)2091511-1 14726831 nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/article/d4a492ba05a64fc6935f5bf38c798d2e kostenfrei https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/toc/1472-6831 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
allfields_unstemmed	10.1186/s12903-019-0967-2 doi (DE-627)DOAJ05552219X (DE-599)DOAJd4a492ba05a64fc6935f5bf38c798d2e DE-627 ger DE-627 rakwb eng RK1-715 Komei Iwai verfasserin aut Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal. Helicobacter pylori infection H. pylori Ulcer Gastric cancer Dental pulp Dental caries Dentistry Isao Watanabe verfasserin aut Toshiro Yamamoto verfasserin aut Nagato Kuriyama verfasserin aut Daisuke Matsui verfasserin aut Ryota Nomura verfasserin aut Yuko Ogaya verfasserin aut Fumishige Oseko verfasserin aut Keiji Adachi verfasserin aut Shigeta Takizawa verfasserin aut Etsuko Ozaki verfasserin aut Teruhide Koyama verfasserin aut Kazuhiko Nakano verfasserin aut Narisato Kanamura verfasserin aut Ritei Uehara verfasserin aut Yoshiyuki Watanabe verfasserin aut In BMC Oral Health BMC, 2003 19(2019), 1, Seite 8 (DE-627)355500108 (DE-600)2091511-1 14726831 nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/article/d4a492ba05a64fc6935f5bf38c798d2e kostenfrei https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/toc/1472-6831 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
allfieldsGer	10.1186/s12903-019-0967-2 doi (DE-627)DOAJ05552219X (DE-599)DOAJd4a492ba05a64fc6935f5bf38c798d2e DE-627 ger DE-627 rakwb eng RK1-715 Komei Iwai verfasserin aut Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal. Helicobacter pylori infection H. pylori Ulcer Gastric cancer Dental pulp Dental caries Dentistry Isao Watanabe verfasserin aut Toshiro Yamamoto verfasserin aut Nagato Kuriyama verfasserin aut Daisuke Matsui verfasserin aut Ryota Nomura verfasserin aut Yuko Ogaya verfasserin aut Fumishige Oseko verfasserin aut Keiji Adachi verfasserin aut Shigeta Takizawa verfasserin aut Etsuko Ozaki verfasserin aut Teruhide Koyama verfasserin aut Kazuhiko Nakano verfasserin aut Narisato Kanamura verfasserin aut Ritei Uehara verfasserin aut Yoshiyuki Watanabe verfasserin aut In BMC Oral Health BMC, 2003 19(2019), 1, Seite 8 (DE-627)355500108 (DE-600)2091511-1 14726831 nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/article/d4a492ba05a64fc6935f5bf38c798d2e kostenfrei https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/toc/1472-6831 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
allfieldsSound	10.1186/s12903-019-0967-2 doi (DE-627)DOAJ05552219X (DE-599)DOAJd4a492ba05a64fc6935f5bf38c798d2e DE-627 ger DE-627 rakwb eng RK1-715 Komei Iwai verfasserin aut Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal. Helicobacter pylori infection H. pylori Ulcer Gastric cancer Dental pulp Dental caries Dentistry Isao Watanabe verfasserin aut Toshiro Yamamoto verfasserin aut Nagato Kuriyama verfasserin aut Daisuke Matsui verfasserin aut Ryota Nomura verfasserin aut Yuko Ogaya verfasserin aut Fumishige Oseko verfasserin aut Keiji Adachi verfasserin aut Shigeta Takizawa verfasserin aut Etsuko Ozaki verfasserin aut Teruhide Koyama verfasserin aut Kazuhiko Nakano verfasserin aut Narisato Kanamura verfasserin aut Ritei Uehara verfasserin aut Yoshiyuki Watanabe verfasserin aut In BMC Oral Health BMC, 2003 19(2019), 1, Seite 8 (DE-627)355500108 (DE-600)2091511-1 14726831 nnns volume:19 year:2019 number:1 pages:8 https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/article/d4a492ba05a64fc6935f5bf38c798d2e kostenfrei https://doi.org/10.1186/s12903-019-0967-2 kostenfrei https://doaj.org/toc/1472-6831 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 8
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authorswithroles_txt_mv	Komei Iwai @@aut@@ Isao Watanabe @@aut@@ Toshiro Yamamoto @@aut@@ Nagato Kuriyama @@aut@@ Daisuke Matsui @@aut@@ Ryota Nomura @@aut@@ Yuko Ogaya @@aut@@ Fumishige Oseko @@aut@@ Keiji Adachi @@aut@@ Shigeta Takizawa @@aut@@ Etsuko Ozaki @@aut@@ Teruhide Koyama @@aut@@ Kazuhiko Nakano @@aut@@ Narisato Kanamura @@aut@@ Ritei Uehara @@aut@@ Yoshiyuki Watanabe @@aut@@
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callnumber-first	R - Medicine
author	Komei Iwai
spellingShingle	Komei Iwai misc RK1-715 misc Helicobacter pylori infection misc H. pylori misc Ulcer misc Gastric cancer misc Dental pulp misc Dental caries misc Dentistry Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults
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topic_title	RK1-715 Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults Helicobacter pylori infection H. pylori Ulcer Gastric cancer Dental pulp Dental caries
topic	misc RK1-715 misc Helicobacter pylori infection misc H. pylori misc Ulcer misc Gastric cancer misc Dental pulp misc Dental caries misc Dentistry
topic_unstemmed	misc RK1-715 misc Helicobacter pylori infection misc H. pylori misc Ulcer misc Gastric cancer misc Dental pulp misc Dental caries misc Dentistry
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title	Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults
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title_full	Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults
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author_browse	Komei Iwai Isao Watanabe Toshiro Yamamoto Nagato Kuriyama Daisuke Matsui Ryota Nomura Yuko Ogaya Fumishige Oseko Keiji Adachi Shigeta Takizawa Etsuko Ozaki Teruhide Koyama Kazuhiko Nakano Narisato Kanamura Ritei Uehara Yoshiyuki Watanabe
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title_sort	association between helicobacter pylori infection and dental pulp reservoirs in japanese adults
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title_auth	Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults
abstract	Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal.
abstractGer	Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal.
abstract_unstemmed	Abstract Background Helicobacter pylori (H. pylori) colonize the stomach and are considered an etiological agent of gastric cancer. The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. Moreover, H. pylori are likely transmitted from dental caries to the root canal.
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title_short	Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults
url	https://doi.org/10.1186/s12903-019-0967-2 https://doaj.org/article/d4a492ba05a64fc6935f5bf38c798d2e https://doaj.org/toc/1472-6831
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author2	Isao Watanabe Toshiro Yamamoto Nagato Kuriyama Daisuke Matsui Ryota Nomura Yuko Ogaya Fumishige Oseko Keiji Adachi Shigeta Takizawa Etsuko Ozaki Teruhide Koyama Kazuhiko Nakano Narisato Kanamura Ritei Uehara Yoshiyuki Watanabe
author2Str	Isao Watanabe Toshiro Yamamoto Nagato Kuriyama Daisuke Matsui Ryota Nomura Yuko Ogaya Fumishige Oseko Keiji Adachi Shigeta Takizawa Etsuko Ozaki Teruhide Koyama Kazuhiko Nakano Narisato Kanamura Ritei Uehara Yoshiyuki Watanabe
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The oral cavity is a transmission route to the stomach, but the exact site of colonization has not yet been explicated. Our study investigated the association between H. pylori infection and presence in oral samples. Methods Dental pulp, supragingival plaque, and saliva from 192 patients visiting the Dentistry’s outpatient clinic were collected for testing. The H. pylori ureA gene was identified via Nested PCR. Urine anti-H. pylori antibody test was utilized to detect infection. Results Twenty-five subjects were found to be antibody-positive. PCR analysis of dental pulp revealed that 23 subjects possessed the ureA gene. Twenty-one subjects were positive for both antibodies and genes in dental pulp. PCR testing revealed that 2 subjects were positive in dental plaque but negative for saliva. The subjects positive for H. pylori in dental pulp expressed clinical signs of severe dental caries. Conclusions H. pylori infected subjects expressed H. pylori in samples from the oral cavity. The main reservoir for infection within the oral cavity was determined to be dental pulp. 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Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults

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