Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study

Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs379...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sergey Tereshchenko [verfasserIn] Edward Kasparov [verfasserIn] Svetlana Zobova [verfasserIn] Marina Smolnikova [verfasserIn] Lidia Evert [verfasserIn] Nadezhda Semenova [verfasserIn] Olga Zaitseva [verfasserIn] Margarita Shubina [verfasserIn] Nina Gorbacheva [verfasserIn] Ludmila Lapteva [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2021.714093

Katalog-ID:	DOAJ055525245

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ055525245
003	DE-627
005	20230308191846.0
007	cr uuu---uuuuu
008	230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3389/fpsyt.2021.714093 \|2 doi
035			\|a (DE-627)DOAJ055525245
035			\|a (DE-599)DOAJ5bec23211b084ba78564af04de77a5ee
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RC435-571
100	0		\|a Sergey Tereshchenko \|e verfasserin \|4 aut
245	1	0	\|a Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study
264		1	\|c 2021
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents.
650		4	\|a oxytocin
650		4	\|a CD38
650		4	\|a OXTR
650		4	\|a rs3796863
650		4	\|a rs53576
650		4	\|a gene polymorphism
653		0	\|a Psychiatry
700	0		\|a Edward Kasparov \|e verfasserin \|4 aut
700	0		\|a Svetlana Zobova \|e verfasserin \|4 aut
700	0		\|a Svetlana Zobova \|e verfasserin \|4 aut
700	0		\|a Marina Smolnikova \|e verfasserin \|4 aut
700	0		\|a Lidia Evert \|e verfasserin \|4 aut
700	0		\|a Nadezhda Semenova \|e verfasserin \|4 aut
700	0		\|a Olga Zaitseva \|e verfasserin \|4 aut
700	0		\|a Margarita Shubina \|e verfasserin \|4 aut
700	0		\|a Nina Gorbacheva \|e verfasserin \|4 aut
700	0		\|a Ludmila Lapteva \|e verfasserin \|4 aut
773	0	8	\|i In \|t Frontiers in Psychiatry \|d Frontiers Media S.A., 2010 \|g 12(2021) \|w (DE-627)631498796 \|w (DE-600)2564218-2 \|x 16640640 \|7 nnns
773	1	8	\|g volume:12 \|g year:2021
856	4	0	\|u https://doi.org/10.3389/fpsyt.2021.714093 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/5bec23211b084ba78564af04de77a5ee \|z kostenfrei
856	4	0	\|u https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/1664-0640 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 12 \|j 2021

Indexfelder

author_variant	s t st e k ek s z sz s z sz m s ms l e le n s ns o z oz m s ms n g ng l l ll
matchkey_str	article:16640640:2021----::xtcnahagnc3otvrataeorltdoscooilhrceitcdfndyteghadifclisusi
hierarchy_sort_str	2021
callnumber-subject-code	RC
publishDate	2021
allfields	10.3389/fpsyt.2021.714093 doi (DE-627)DOAJ055525245 (DE-599)DOAJ5bec23211b084ba78564af04de77a5ee DE-627 ger DE-627 rakwb eng RC435-571 Sergey Tereshchenko verfasserin aut Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents. oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism Psychiatry Edward Kasparov verfasserin aut Svetlana Zobova verfasserin aut Svetlana Zobova verfasserin aut Marina Smolnikova verfasserin aut Lidia Evert verfasserin aut Nadezhda Semenova verfasserin aut Olga Zaitseva verfasserin aut Margarita Shubina verfasserin aut Nina Gorbacheva verfasserin aut Ludmila Lapteva verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.714093 kostenfrei https://doaj.org/article/5bec23211b084ba78564af04de77a5ee kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
spelling	10.3389/fpsyt.2021.714093 doi (DE-627)DOAJ055525245 (DE-599)DOAJ5bec23211b084ba78564af04de77a5ee DE-627 ger DE-627 rakwb eng RC435-571 Sergey Tereshchenko verfasserin aut Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents. oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism Psychiatry Edward Kasparov verfasserin aut Svetlana Zobova verfasserin aut Svetlana Zobova verfasserin aut Marina Smolnikova verfasserin aut Lidia Evert verfasserin aut Nadezhda Semenova verfasserin aut Olga Zaitseva verfasserin aut Margarita Shubina verfasserin aut Nina Gorbacheva verfasserin aut Ludmila Lapteva verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.714093 kostenfrei https://doaj.org/article/5bec23211b084ba78564af04de77a5ee kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfields_unstemmed	10.3389/fpsyt.2021.714093 doi (DE-627)DOAJ055525245 (DE-599)DOAJ5bec23211b084ba78564af04de77a5ee DE-627 ger DE-627 rakwb eng RC435-571 Sergey Tereshchenko verfasserin aut Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents. oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism Psychiatry Edward Kasparov verfasserin aut Svetlana Zobova verfasserin aut Svetlana Zobova verfasserin aut Marina Smolnikova verfasserin aut Lidia Evert verfasserin aut Nadezhda Semenova verfasserin aut Olga Zaitseva verfasserin aut Margarita Shubina verfasserin aut Nina Gorbacheva verfasserin aut Ludmila Lapteva verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.714093 kostenfrei https://doaj.org/article/5bec23211b084ba78564af04de77a5ee kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsGer	10.3389/fpsyt.2021.714093 doi (DE-627)DOAJ055525245 (DE-599)DOAJ5bec23211b084ba78564af04de77a5ee DE-627 ger DE-627 rakwb eng RC435-571 Sergey Tereshchenko verfasserin aut Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents. oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism Psychiatry Edward Kasparov verfasserin aut Svetlana Zobova verfasserin aut Svetlana Zobova verfasserin aut Marina Smolnikova verfasserin aut Lidia Evert verfasserin aut Nadezhda Semenova verfasserin aut Olga Zaitseva verfasserin aut Margarita Shubina verfasserin aut Nina Gorbacheva verfasserin aut Ludmila Lapteva verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.714093 kostenfrei https://doaj.org/article/5bec23211b084ba78564af04de77a5ee kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fpsyt.2021.714093 doi (DE-627)DOAJ055525245 (DE-599)DOAJ5bec23211b084ba78564af04de77a5ee DE-627 ger DE-627 rakwb eng RC435-571 Sergey Tereshchenko verfasserin aut Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents. oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism Psychiatry Edward Kasparov verfasserin aut Svetlana Zobova verfasserin aut Svetlana Zobova verfasserin aut Marina Smolnikova verfasserin aut Lidia Evert verfasserin aut Nadezhda Semenova verfasserin aut Olga Zaitseva verfasserin aut Margarita Shubina verfasserin aut Nina Gorbacheva verfasserin aut Ludmila Lapteva verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.714093 kostenfrei https://doaj.org/article/5bec23211b084ba78564af04de77a5ee kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Psychiatry 12(2021) volume:12 year:2021
sourceStr	In Frontiers in Psychiatry 12(2021) volume:12 year:2021
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism Psychiatry
isfreeaccess_bool	true
container_title	Frontiers in Psychiatry
authorswithroles_txt_mv	Sergey Tereshchenko @@aut@@ Edward Kasparov @@aut@@ Svetlana Zobova @@aut@@ Marina Smolnikova @@aut@@ Lidia Evert @@aut@@ Nadezhda Semenova @@aut@@ Olga Zaitseva @@aut@@ Margarita Shubina @@aut@@ Nina Gorbacheva @@aut@@ Ludmila Lapteva @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	631498796
id	DOAJ055525245
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ055525245</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308191846.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fpsyt.2021.714093</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ055525245</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5bec23211b084ba78564af04de77a5ee</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC435-571</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Sergey Tereshchenko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">oxytocin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CD38</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">OXTR</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">rs3796863</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">rs53576</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">gene polymorphism</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Psychiatry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edward Kasparov</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Svetlana Zobova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Svetlana Zobova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marina Smolnikova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lidia Evert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nadezhda Semenova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olga Zaitseva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Margarita Shubina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nina Gorbacheva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ludmila Lapteva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Frontiers in Psychiatry</subfield><subfield code="d">Frontiers Media S.A., 2010</subfield><subfield code="g">12(2021)</subfield><subfield code="w">(DE-627)631498796</subfield><subfield code="w">(DE-600)2564218-2</subfield><subfield code="x">16640640</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2021</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3389/fpsyt.2021.714093</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/5bec23211b084ba78564af04de77a5ee</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1664-0640</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2021</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Sergey Tereshchenko
spellingShingle	Sergey Tereshchenko misc RC435-571 misc oxytocin misc CD38 misc OXTR misc rs3796863 misc rs53576 misc gene polymorphism misc Psychiatry Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study
authorStr	Sergey Tereshchenko
ppnlink_with_tag_str_mv	@@773@@(DE-627)631498796
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RC435-571
illustrated	Not Illustrated
issn	16640640
topic_title	RC435-571 Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study oxytocin CD38 OXTR rs3796863 rs53576 gene polymorphism
topic	misc RC435-571 misc oxytocin misc CD38 misc OXTR misc rs3796863 misc rs53576 misc gene polymorphism misc Psychiatry
topic_unstemmed	misc RC435-571 misc oxytocin misc CD38 misc OXTR misc rs3796863 misc rs53576 misc gene polymorphism misc Psychiatry
topic_browse	misc RC435-571 misc oxytocin misc CD38 misc OXTR misc rs3796863 misc rs53576 misc gene polymorphism misc Psychiatry
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Frontiers in Psychiatry
hierarchy_parent_id	631498796
hierarchy_top_title	Frontiers in Psychiatry
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)631498796 (DE-600)2564218-2
title	Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study
ctrlnum	(DE-627)DOAJ055525245 (DE-599)DOAJ5bec23211b084ba78564af04de77a5ee
title_full	Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study
author_sort	Sergey Tereshchenko
journal	Frontiers in Psychiatry
journalStr	Frontiers in Psychiatry
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2021
contenttype_str_mv	txt
author_browse	Sergey Tereshchenko Edward Kasparov Svetlana Zobova Marina Smolnikova Lidia Evert Nadezhda Semenova Olga Zaitseva Margarita Shubina Nina Gorbacheva Ludmila Lapteva
container_volume	12
class	RC435-571
format_se	Elektronische Aufsätze
author-letter	Sergey Tereshchenko
doi_str_mv	10.3389/fpsyt.2021.714093
author2-role	verfasserin
title_sort	oxytocin pathway gene (cd38, oxtr) variants are not related to psychosocial characteristics defined by strengths and difficulties questionnaire in adolescents: a field school-based study
callnumber	RC435-571
title_auth	Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study
abstract	Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents.
abstractGer	Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents.
abstract_unstemmed	Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study
url	https://doi.org/10.3389/fpsyt.2021.714093 https://doaj.org/article/5bec23211b084ba78564af04de77a5ee https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full https://doaj.org/toc/1664-0640
remote_bool	true
author2	Edward Kasparov Svetlana Zobova Marina Smolnikova Lidia Evert Nadezhda Semenova Olga Zaitseva Margarita Shubina Nina Gorbacheva Ludmila Lapteva
author2Str	Edward Kasparov Svetlana Zobova Marina Smolnikova Lidia Evert Nadezhda Semenova Olga Zaitseva Margarita Shubina Nina Gorbacheva Ludmila Lapteva
ppnlink	631498796
callnumber-subject	RC - Internal Medicine
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3389/fpsyt.2021.714093
callnumber-a	RC435-571
up_date	2024-07-03T15:29:42.242Z
_version_	1803572302049181696
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ055525245</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308191846.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fpsyt.2021.714093</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ055525245</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5bec23211b084ba78564af04de77a5ee</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC435-571</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Sergey Tereshchenko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: CD38 is a transmembrane glycoprotein that regulates oxytocin (OT) production and influences social interactions. The oxytocin receptor (OXTR) has been studied intensively regarding its association with human psychosocial functions. Many studies have demonstrated a link between CD38 rs3796863 and OXTR rs53576 polymorphic regions and psychosocial characteristics as well as various psychiatric disorders in adolescents. Some studies, however, have reported null findings.Methods: The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathologic screening tool recommended for detecting psychosocial problems and psychiatric disorders in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18), explored the SDQ scales in relation to polymorphisms of the CD38 and the OXTR genes (rs3796863 and rs53576, respectively).Results: None of the studied genotypes were associated with the SDQ results for the complete sample with presumed statistical power as 0.80 to detect a medium-size effect (Cramer's V = 0.3) at α = 0.0083. Post-hoc analysis in subgroups showed that OT pathway high activity may cause some negative consequences, such as emotional instability in older (aged 15–18) adolescent boys who are carriers of the rs53576 GG variant.Conclusion: Variations at the CD38 rs3796863 and OXTR rs53576 loci were not associated with psychosocial characteristics of adolescents assessed with the SDQ. In studies with a similar design, we recommend replication with larger samples and greater power to detect small effects, especially in age–sex subgroups of adolescents.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">oxytocin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CD38</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">OXTR</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">rs3796863</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">rs53576</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">gene polymorphism</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Psychiatry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edward Kasparov</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Svetlana Zobova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Svetlana Zobova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marina Smolnikova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lidia Evert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nadezhda Semenova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olga Zaitseva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Margarita Shubina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nina Gorbacheva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ludmila Lapteva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Frontiers in Psychiatry</subfield><subfield code="d">Frontiers Media S.A., 2010</subfield><subfield code="g">12(2021)</subfield><subfield code="w">(DE-627)631498796</subfield><subfield code="w">(DE-600)2564218-2</subfield><subfield code="x">16640640</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2021</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3389/fpsyt.2021.714093</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/5bec23211b084ba78564af04de77a5ee</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714093/full</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1664-0640</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2021</subfield></datafield></record></collection>
score	7.3983774

Nicht das Richtige dabei?

Schreiben Sie uns!

Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?