New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells

We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignan...
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Autor*in:	Cristian Hernández [verfasserIn] Gustavo Moreno [verfasserIn] Angie Herrera-R [verfasserIn] Wilson Cardona-G [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	curcumin resveratrol hybrid molecules colorectal cancer cytotoxicity antiproliferative activity

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 26(2021), 9, p 2661
Übergeordnetes Werk:	volume:26 ; year:2021 ; number:9, p 2661

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules26092661

Katalog-ID:	DOAJ055669557

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520			\|a We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids <b<3e</b< and <b<3i</b< (for SW480) and <b<3a</b<, <b<3e</b< and <b<3k</b< (for SW620) displayed the best cytotoxic activity with IC<sub<50</sub< values ranging from 11.52 ± 2.78 to 29.33 ± 4.73 µM for both cell lines, with selectivity indices (SI) higher than 1, after 48 h of treatment. Selectivity indices were even higher than those reported for the reference drug, 5-fluorouracil (SI = 0.96), the starting compound resveratrol (SI = 0.45) and the equimolar mixture of curcumin plus resveratrol (SI = 0.77). The previous hybrids showed good antiproliferative activity.
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allfieldsSound	10.3390/molecules26092661 doi (DE-627)DOAJ055669557 (DE-599)DOAJ931387aa57024d0f9294b2b4047dbc36 DE-627 ger DE-627 rakwb eng QD241-441 Cristian Hernández verfasserin aut New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids <b<3e</b< and <b<3i</b< (for SW480) and <b<3a</b<, <b<3e</b< and <b<3k</b< (for SW620) displayed the best cytotoxic activity with IC<sub<50</sub< values ranging from 11.52 ± 2.78 to 29.33 ± 4.73 µM for both cell lines, with selectivity indices (SI) higher than 1, after 48 h of treatment. Selectivity indices were even higher than those reported for the reference drug, 5-fluorouracil (SI = 0.96), the starting compound resveratrol (SI = 0.45) and the equimolar mixture of curcumin plus resveratrol (SI = 0.77). The previous hybrids showed good antiproliferative activity. curcumin resveratrol hybrid molecules colorectal cancer cytotoxicity antiproliferative activity Organic chemistry Gustavo Moreno verfasserin aut Angie Herrera-R verfasserin aut Wilson Cardona-G verfasserin aut In Molecules MDPI AG, 2003 26(2021), 9, p 2661 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:9, p 2661 https://doi.org/10.3390/molecules26092661 kostenfrei https://doaj.org/article/931387aa57024d0f9294b2b4047dbc36 kostenfrei https://www.mdpi.com/1420-3049/26/9/2661 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 9, p 2661
language	English
source	In Molecules 26(2021), 9, p 2661 volume:26 year:2021 number:9, p 2661
sourceStr	In Molecules 26(2021), 9, p 2661 volume:26 year:2021 number:9, p 2661
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	curcumin resveratrol hybrid molecules colorectal cancer cytotoxicity antiproliferative activity Organic chemistry
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container_title	Molecules
authorswithroles_txt_mv	Cristian Hernández @@aut@@ Gustavo Moreno @@aut@@ Angie Herrera-R @@aut@@ Wilson Cardona-G @@aut@@
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callnumber-first	Q - Science
author	Cristian Hernández
spellingShingle	Cristian Hernández misc QD241-441 misc curcumin misc resveratrol misc hybrid molecules misc colorectal cancer misc cytotoxicity misc antiproliferative activity misc Organic chemistry New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells
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topic_title	QD241-441 New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells curcumin resveratrol hybrid molecules colorectal cancer cytotoxicity antiproliferative activity
topic	misc QD241-441 misc curcumin misc resveratrol misc hybrid molecules misc colorectal cancer misc cytotoxicity misc antiproliferative activity misc Organic chemistry
topic_unstemmed	misc QD241-441 misc curcumin misc resveratrol misc hybrid molecules misc colorectal cancer misc cytotoxicity misc antiproliferative activity misc Organic chemistry
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title	New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells
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title_full	New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells
author_sort	Cristian Hernández
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author_browse	Cristian Hernández Gustavo Moreno Angie Herrera-R Wilson Cardona-G
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title_sort	new hybrids based on curcumin and resveratrol: synthesis, cytotoxicity and antiproliferative activity against colorectal cancer cells
callnumber	QD241-441
title_auth	New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells
abstract	We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids <b<3e</b< and <b<3i</b< (for SW480) and <b<3a</b<, <b<3e</b< and <b<3k</b< (for SW620) displayed the best cytotoxic activity with IC<sub<50</sub< values ranging from 11.52 ± 2.78 to 29.33 ± 4.73 µM for both cell lines, with selectivity indices (SI) higher than 1, after 48 h of treatment. Selectivity indices were even higher than those reported for the reference drug, 5-fluorouracil (SI = 0.96), the starting compound resveratrol (SI = 0.45) and the equimolar mixture of curcumin plus resveratrol (SI = 0.77). The previous hybrids showed good antiproliferative activity.
abstractGer	We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids <b<3e</b< and <b<3i</b< (for SW480) and <b<3a</b<, <b<3e</b< and <b<3k</b< (for SW620) displayed the best cytotoxic activity with IC<sub<50</sub< values ranging from 11.52 ± 2.78 to 29.33 ± 4.73 µM for both cell lines, with selectivity indices (SI) higher than 1, after 48 h of treatment. Selectivity indices were even higher than those reported for the reference drug, 5-fluorouracil (SI = 0.96), the starting compound resveratrol (SI = 0.45) and the equimolar mixture of curcumin plus resveratrol (SI = 0.77). The previous hybrids showed good antiproliferative activity.
abstract_unstemmed	We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids <b<3e</b< and <b<3i</b< (for SW480) and <b<3a</b<, <b<3e</b< and <b<3k</b< (for SW620) displayed the best cytotoxic activity with IC<sub<50</sub< values ranging from 11.52 ± 2.78 to 29.33 ± 4.73 µM for both cell lines, with selectivity indices (SI) higher than 1, after 48 h of treatment. Selectivity indices were even higher than those reported for the reference drug, 5-fluorouracil (SI = 0.96), the starting compound resveratrol (SI = 0.45) and the equimolar mixture of curcumin plus resveratrol (SI = 0.77). The previous hybrids showed good antiproliferative activity.
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title_short	New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer Cells
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