Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells

Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MT...
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Autor*in:	Haiying LI [verfasserIn] Qingling WANG [verfasserIn] Lin ZHANG [verfasserIn] Haijun BAO [verfasserIn] Heng ZHANG [verfasserIn]

Format:	E-Artikel
Sprache:	Chinesisch

Erschienen:	2015

Schlagwörter:	Lung neoplasms Metastasis associated gene 3 (MTA3) Apoptosis A549 H157

Übergeordnetes Werk:	In: Chinese Journal of Lung Cancer - Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2008, 18(2015), 10, Seite 610-615
Übergeordnetes Werk:	volume:18 ; year:2015 ; number:10 ; pages:610-615

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3779/j.issn.1009-3419.2015.10.02

Katalog-ID:	DOAJ055747949

Internformat


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520			\|a Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression.
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allfields	10.3779/j.issn.1009-3419.2015.10.02 doi (DE-627)DOAJ055747949 (DE-599)DOAJab78e97e20ef4f0389a9c12eb3d09c8d DE-627 ger DE-627 rakwb chi RC254-282 Haiying LI verfasserin aut Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. Lung neoplasms Metastasis associated gene 3 (MTA3) Apoptosis A549 H157 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingling WANG verfasserin aut Lin ZHANG verfasserin aut Haijun BAO verfasserin aut Heng ZHANG verfasserin aut In Chinese Journal of Lung Cancer Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2008 18(2015), 10, Seite 610-615 (DE-627)572421125 (DE-600)2438672-8 19996187 nnns volume:18 year:2015 number:10 pages:610-615 https://doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/article/ab78e97e20ef4f0389a9c12eb3d09c8d kostenfrei http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/toc/1009-3419 Journal toc kostenfrei https://doaj.org/toc/1999-6187 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 10 610-615
spelling	10.3779/j.issn.1009-3419.2015.10.02 doi (DE-627)DOAJ055747949 (DE-599)DOAJab78e97e20ef4f0389a9c12eb3d09c8d DE-627 ger DE-627 rakwb chi RC254-282 Haiying LI verfasserin aut Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. Lung neoplasms Metastasis associated gene 3 (MTA3) Apoptosis A549 H157 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingling WANG verfasserin aut Lin ZHANG verfasserin aut Haijun BAO verfasserin aut Heng ZHANG verfasserin aut In Chinese Journal of Lung Cancer Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2008 18(2015), 10, Seite 610-615 (DE-627)572421125 (DE-600)2438672-8 19996187 nnns volume:18 year:2015 number:10 pages:610-615 https://doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/article/ab78e97e20ef4f0389a9c12eb3d09c8d kostenfrei http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/toc/1009-3419 Journal toc kostenfrei https://doaj.org/toc/1999-6187 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 10 610-615
allfields_unstemmed	10.3779/j.issn.1009-3419.2015.10.02 doi (DE-627)DOAJ055747949 (DE-599)DOAJab78e97e20ef4f0389a9c12eb3d09c8d DE-627 ger DE-627 rakwb chi RC254-282 Haiying LI verfasserin aut Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. Lung neoplasms Metastasis associated gene 3 (MTA3) Apoptosis A549 H157 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingling WANG verfasserin aut Lin ZHANG verfasserin aut Haijun BAO verfasserin aut Heng ZHANG verfasserin aut In Chinese Journal of Lung Cancer Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2008 18(2015), 10, Seite 610-615 (DE-627)572421125 (DE-600)2438672-8 19996187 nnns volume:18 year:2015 number:10 pages:610-615 https://doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/article/ab78e97e20ef4f0389a9c12eb3d09c8d kostenfrei http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/toc/1009-3419 Journal toc kostenfrei https://doaj.org/toc/1999-6187 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 10 610-615
allfieldsGer	10.3779/j.issn.1009-3419.2015.10.02 doi (DE-627)DOAJ055747949 (DE-599)DOAJab78e97e20ef4f0389a9c12eb3d09c8d DE-627 ger DE-627 rakwb chi RC254-282 Haiying LI verfasserin aut Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. Lung neoplasms Metastasis associated gene 3 (MTA3) Apoptosis A549 H157 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingling WANG verfasserin aut Lin ZHANG verfasserin aut Haijun BAO verfasserin aut Heng ZHANG verfasserin aut In Chinese Journal of Lung Cancer Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2008 18(2015), 10, Seite 610-615 (DE-627)572421125 (DE-600)2438672-8 19996187 nnns volume:18 year:2015 number:10 pages:610-615 https://doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/article/ab78e97e20ef4f0389a9c12eb3d09c8d kostenfrei http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/toc/1009-3419 Journal toc kostenfrei https://doaj.org/toc/1999-6187 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 10 610-615
allfieldsSound	10.3779/j.issn.1009-3419.2015.10.02 doi (DE-627)DOAJ055747949 (DE-599)DOAJab78e97e20ef4f0389a9c12eb3d09c8d DE-627 ger DE-627 rakwb chi RC254-282 Haiying LI verfasserin aut Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression. Lung neoplasms Metastasis associated gene 3 (MTA3) Apoptosis A549 H157 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Qingling WANG verfasserin aut Lin ZHANG verfasserin aut Haijun BAO verfasserin aut Heng ZHANG verfasserin aut In Chinese Journal of Lung Cancer Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2008 18(2015), 10, Seite 610-615 (DE-627)572421125 (DE-600)2438672-8 19996187 nnns volume:18 year:2015 number:10 pages:610-615 https://doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/article/ab78e97e20ef4f0389a9c12eb3d09c8d kostenfrei http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.02 kostenfrei https://doaj.org/toc/1009-3419 Journal toc kostenfrei https://doaj.org/toc/1999-6187 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2015 10 610-615
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callnumber-first	R - Medicine
author	Haiying LI
spellingShingle	Haiying LI misc RC254-282 misc Lung neoplasms misc Metastasis associated gene 3 (MTA3) misc Apoptosis misc A549 misc H157 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells
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topic_title	RC254-282 Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells Lung neoplasms Metastasis associated gene 3 (MTA3) Apoptosis A549 H157
topic	misc RC254-282 misc Lung neoplasms misc Metastasis associated gene 3 (MTA3) misc Apoptosis misc A549 misc H157 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Lung neoplasms misc Metastasis associated gene 3 (MTA3) misc Apoptosis misc A549 misc H157 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells
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title_full	Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells
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title_sort	regulation mechanism of mta3 in the apoptosis of nsclc cells
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title_auth	Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells
abstract	Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression.
abstractGer	Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression.
abstract_unstemmed	Background and objective Metastasis-associated protein 3 (MTA3) was originally found as a member of a small protein family (including MTA1, MTA2 and MTA3), and it has been proven that MTA3 had different roles in different types of human cancers. The aim of this study is to explore the function of MTA3 to regulate the cell apoptosis in lung cancer. Methods Western blot and Real-time PCR were used to detect the expression level of MTA3 after transfection in non-small cell lung cancer (NSCLC) cells A549 and H157. Apoptosis analysis was used to detect the change of cell apoptosis with upregulated/downregulated of MTA3, and Western blot was used to detect the the expression of the protein related with apoptosis, while downregulate the expression of MTA3 in NSCLC cells A549 and H157. Results Downregulated of endogenous MTA3 could promote apoptosis in NSCLC cells, meanwhile, siMTA3 could upregulate the protein of BAX, Cleved-Caspase-3, p-PARP, and dowmregulate the protein of Bcl-2. Conclusion The data we present here indicate that MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX, PARP expression.
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title_short	Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells
url	https://doi.org/10.3779/j.issn.1009-3419.2015.10.02 https://doaj.org/article/ab78e97e20ef4f0389a9c12eb3d09c8d http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.02 https://doaj.org/toc/1009-3419 https://doaj.org/toc/1999-6187
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up_date	2024-07-03T16:47:41.887Z
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Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells

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