Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy contro...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Felicitas Schulz [verfasserIn] Ekkehart Jenetzky [verfasserIn] Nadine Zwink [verfasserIn] Charlotte Bendixen [verfasserIn] Florian Kipfmueller [verfasserIn] Neysan Rafat [verfasserIn] Andreas Heydweiller [verfasserIn] Lucas Wessel [verfasserIn] Heiko Reutter [verfasserIn] Andreas Mueller [verfasserIn] Thomas Schaible [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Birth defect CDH Congenital diaphragmatic hernia Environmental risk factor

Übergeordnetes Werk:	In: BMC Pediatrics - BMC, 2003, 21(2021), 1, Seite 8
Übergeordnetes Werk:	volume:21 ; year:2021 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12887-021-02748-3

Katalog-ID:	DOAJ055884741

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520			\|a Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.
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allfields	10.1186/s12887-021-02748-3 doi (DE-627)DOAJ055884741 (DE-599)DOAJ8f5f3fdfac5c4967aecc5710413a8ed6 DE-627 ger DE-627 rakwb eng RJ1-570 Felicitas Schulz verfasserin aut Parental risk factors for congenital diaphragmatic hernia – a large German case-control study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH. Birth defect CDH Congenital diaphragmatic hernia Environmental risk factor Pediatrics Ekkehart Jenetzky verfasserin aut Nadine Zwink verfasserin aut Charlotte Bendixen verfasserin aut Florian Kipfmueller verfasserin aut Neysan Rafat verfasserin aut Andreas Heydweiller verfasserin aut Lucas Wessel verfasserin aut Heiko Reutter verfasserin aut Andreas Mueller verfasserin aut Thomas Schaible verfasserin aut In BMC Pediatrics BMC, 2003 21(2021), 1, Seite 8 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:21 year:2021 number:1 pages:8 https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/article/8f5f3fdfac5c4967aecc5710413a8ed6 kostenfrei https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 8
spelling	10.1186/s12887-021-02748-3 doi (DE-627)DOAJ055884741 (DE-599)DOAJ8f5f3fdfac5c4967aecc5710413a8ed6 DE-627 ger DE-627 rakwb eng RJ1-570 Felicitas Schulz verfasserin aut Parental risk factors for congenital diaphragmatic hernia – a large German case-control study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH. Birth defect CDH Congenital diaphragmatic hernia Environmental risk factor Pediatrics Ekkehart Jenetzky verfasserin aut Nadine Zwink verfasserin aut Charlotte Bendixen verfasserin aut Florian Kipfmueller verfasserin aut Neysan Rafat verfasserin aut Andreas Heydweiller verfasserin aut Lucas Wessel verfasserin aut Heiko Reutter verfasserin aut Andreas Mueller verfasserin aut Thomas Schaible verfasserin aut In BMC Pediatrics BMC, 2003 21(2021), 1, Seite 8 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:21 year:2021 number:1 pages:8 https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/article/8f5f3fdfac5c4967aecc5710413a8ed6 kostenfrei https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 8
allfields_unstemmed	10.1186/s12887-021-02748-3 doi (DE-627)DOAJ055884741 (DE-599)DOAJ8f5f3fdfac5c4967aecc5710413a8ed6 DE-627 ger DE-627 rakwb eng RJ1-570 Felicitas Schulz verfasserin aut Parental risk factors for congenital diaphragmatic hernia – a large German case-control study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH. Birth defect CDH Congenital diaphragmatic hernia Environmental risk factor Pediatrics Ekkehart Jenetzky verfasserin aut Nadine Zwink verfasserin aut Charlotte Bendixen verfasserin aut Florian Kipfmueller verfasserin aut Neysan Rafat verfasserin aut Andreas Heydweiller verfasserin aut Lucas Wessel verfasserin aut Heiko Reutter verfasserin aut Andreas Mueller verfasserin aut Thomas Schaible verfasserin aut In BMC Pediatrics BMC, 2003 21(2021), 1, Seite 8 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:21 year:2021 number:1 pages:8 https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/article/8f5f3fdfac5c4967aecc5710413a8ed6 kostenfrei https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 8
allfieldsGer	10.1186/s12887-021-02748-3 doi (DE-627)DOAJ055884741 (DE-599)DOAJ8f5f3fdfac5c4967aecc5710413a8ed6 DE-627 ger DE-627 rakwb eng RJ1-570 Felicitas Schulz verfasserin aut Parental risk factors for congenital diaphragmatic hernia – a large German case-control study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH. Birth defect CDH Congenital diaphragmatic hernia Environmental risk factor Pediatrics Ekkehart Jenetzky verfasserin aut Nadine Zwink verfasserin aut Charlotte Bendixen verfasserin aut Florian Kipfmueller verfasserin aut Neysan Rafat verfasserin aut Andreas Heydweiller verfasserin aut Lucas Wessel verfasserin aut Heiko Reutter verfasserin aut Andreas Mueller verfasserin aut Thomas Schaible verfasserin aut In BMC Pediatrics BMC, 2003 21(2021), 1, Seite 8 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:21 year:2021 number:1 pages:8 https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/article/8f5f3fdfac5c4967aecc5710413a8ed6 kostenfrei https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 8
allfieldsSound	10.1186/s12887-021-02748-3 doi (DE-627)DOAJ055884741 (DE-599)DOAJ8f5f3fdfac5c4967aecc5710413a8ed6 DE-627 ger DE-627 rakwb eng RJ1-570 Felicitas Schulz verfasserin aut Parental risk factors for congenital diaphragmatic hernia – a large German case-control study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH. Birth defect CDH Congenital diaphragmatic hernia Environmental risk factor Pediatrics Ekkehart Jenetzky verfasserin aut Nadine Zwink verfasserin aut Charlotte Bendixen verfasserin aut Florian Kipfmueller verfasserin aut Neysan Rafat verfasserin aut Andreas Heydweiller verfasserin aut Lucas Wessel verfasserin aut Heiko Reutter verfasserin aut Andreas Mueller verfasserin aut Thomas Schaible verfasserin aut In BMC Pediatrics BMC, 2003 21(2021), 1, Seite 8 (DE-627)326643621 (DE-600)2041342-7 14712431 nnns volume:21 year:2021 number:1 pages:8 https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/article/8f5f3fdfac5c4967aecc5710413a8ed6 kostenfrei https://doi.org/10.1186/s12887-021-02748-3 kostenfrei https://doaj.org/toc/1471-2431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2021 1 8
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authorswithroles_txt_mv	Felicitas Schulz @@aut@@ Ekkehart Jenetzky @@aut@@ Nadine Zwink @@aut@@ Charlotte Bendixen @@aut@@ Florian Kipfmueller @@aut@@ Neysan Rafat @@aut@@ Andreas Heydweiller @@aut@@ Lucas Wessel @@aut@@ Heiko Reutter @@aut@@ Andreas Mueller @@aut@@ Thomas Schaible @@aut@@
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callnumber-first	R - Medicine
author	Felicitas Schulz
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topic_title	RJ1-570 Parental risk factors for congenital diaphragmatic hernia – a large German case-control study Birth defect CDH Congenital diaphragmatic hernia Environmental risk factor
topic	misc RJ1-570 misc Birth defect misc CDH misc Congenital diaphragmatic hernia misc Environmental risk factor misc Pediatrics
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title	Parental risk factors for congenital diaphragmatic hernia – a large German case-control study
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author_browse	Felicitas Schulz Ekkehart Jenetzky Nadine Zwink Charlotte Bendixen Florian Kipfmueller Neysan Rafat Andreas Heydweiller Lucas Wessel Heiko Reutter Andreas Mueller Thomas Schaible
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title_sort	parental risk factors for congenital diaphragmatic hernia – a large german case-control study
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title_auth	Parental risk factors for congenital diaphragmatic hernia – a large German case-control study
abstract	Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.
abstractGer	Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.
abstract_unstemmed	Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.
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title_short	Parental risk factors for congenital diaphragmatic hernia – a large German case-control study
url	https://doi.org/10.1186/s12887-021-02748-3 https://doaj.org/article/8f5f3fdfac5c4967aecc5710413a8ed6 https://doaj.org/toc/1471-2431
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author2	Ekkehart Jenetzky Nadine Zwink Charlotte Bendixen Florian Kipfmueller Neysan Rafat Andreas Heydweiller Lucas Wessel Heiko Reutter Andreas Mueller Thomas Schaible
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up_date	2024-07-03T17:36:02.814Z
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Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

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