Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immu...
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Autor*in:	Qianqian Yin [verfasserIn] Longyun Wang [verfasserIn] Haiyang Yu [verfasserIn] Daquan Chen [verfasserIn] Wenwei Zhu [verfasserIn] Changgang Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	JAK STAT signaling pathway polyphenols phytochemicals

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2021.716672

Katalog-ID:	DOAJ055927599

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spelling	10.3389/fphar.2021.716672 doi (DE-627)DOAJ055927599 (DE-599)DOAJe1ced3d877c9491480618dec66043d37 DE-627 ger DE-627 rakwb eng RM1-950 Qianqian Yin verfasserin aut Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immune mechanisms. Owing to the nature of this pathway and its potential cross-epitopes with multiple alternative pathways, the long-term efficacy of monotherapy-based adaptive targeting therapy is limited, and the majority of drugs targeting STATs are still in the preclinical phase. Meanwhile, curcumin, quercetin, and several kinds of plant polyphenol chemicals play roles in multiple sites of the JAK-STAT pathway to suppress abnormal activation. Polyphenol compounds have shown remarkable effects by acting on the JAK-STAT pathway in anti-inflammatory, antitumor, and cardiovascular disease control. This review summarizes the pharmacological effects of more than 20 kinds of phytochemicals on JAK-STAT signaling pathway according to the chemical structure of polyphenolic phytochemicals. JAK STAT signaling pathway polyphenols phytochemicals Therapeutics. Pharmacology Longyun Wang verfasserin aut Haiyang Yu verfasserin aut Daquan Chen verfasserin aut Wenwei Zhu verfasserin aut Changgang Sun verfasserin aut Changgang Sun verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 12(2021) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:12 year:2021 https://doi.org/10.3389/fphar.2021.716672 kostenfrei https://doaj.org/article/e1ced3d877c9491480618dec66043d37 kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2021.716672/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
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allfieldsSound	10.3389/fphar.2021.716672 doi (DE-627)DOAJ055927599 (DE-599)DOAJe1ced3d877c9491480618dec66043d37 DE-627 ger DE-627 rakwb eng RM1-950 Qianqian Yin verfasserin aut Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immune mechanisms. Owing to the nature of this pathway and its potential cross-epitopes with multiple alternative pathways, the long-term efficacy of monotherapy-based adaptive targeting therapy is limited, and the majority of drugs targeting STATs are still in the preclinical phase. Meanwhile, curcumin, quercetin, and several kinds of plant polyphenol chemicals play roles in multiple sites of the JAK-STAT pathway to suppress abnormal activation. Polyphenol compounds have shown remarkable effects by acting on the JAK-STAT pathway in anti-inflammatory, antitumor, and cardiovascular disease control. This review summarizes the pharmacological effects of more than 20 kinds of phytochemicals on JAK-STAT signaling pathway according to the chemical structure of polyphenolic phytochemicals. JAK STAT signaling pathway polyphenols phytochemicals Therapeutics. Pharmacology Longyun Wang verfasserin aut Haiyang Yu verfasserin aut Daquan Chen verfasserin aut Wenwei Zhu verfasserin aut Changgang Sun verfasserin aut Changgang Sun verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 12(2021) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:12 year:2021 https://doi.org/10.3389/fphar.2021.716672 kostenfrei https://doaj.org/article/e1ced3d877c9491480618dec66043d37 kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2021.716672/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
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container_title	Frontiers in Pharmacology
authorswithroles_txt_mv	Qianqian Yin @@aut@@ Longyun Wang @@aut@@ Haiyang Yu @@aut@@ Daquan Chen @@aut@@ Wenwei Zhu @@aut@@ Changgang Sun @@aut@@
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callnumber-first	R - Medicine
author	Qianqian Yin
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topic_title	RM1-950 Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway JAK STAT signaling pathway polyphenols phytochemicals
topic	misc RM1-950 misc JAK misc STAT misc signaling pathway misc polyphenols misc phytochemicals misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc JAK misc STAT misc signaling pathway misc polyphenols misc phytochemicals misc Therapeutics. Pharmacology
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title	Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
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title_full	Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
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title_sort	pharmacological effects of polyphenol phytochemicals on the jak-stat signaling pathway
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title_auth	Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
abstract	The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immune mechanisms. Owing to the nature of this pathway and its potential cross-epitopes with multiple alternative pathways, the long-term efficacy of monotherapy-based adaptive targeting therapy is limited, and the majority of drugs targeting STATs are still in the preclinical phase. Meanwhile, curcumin, quercetin, and several kinds of plant polyphenol chemicals play roles in multiple sites of the JAK-STAT pathway to suppress abnormal activation. Polyphenol compounds have shown remarkable effects by acting on the JAK-STAT pathway in anti-inflammatory, antitumor, and cardiovascular disease control. This review summarizes the pharmacological effects of more than 20 kinds of phytochemicals on JAK-STAT signaling pathway according to the chemical structure of polyphenolic phytochemicals.
abstractGer	The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immune mechanisms. Owing to the nature of this pathway and its potential cross-epitopes with multiple alternative pathways, the long-term efficacy of monotherapy-based adaptive targeting therapy is limited, and the majority of drugs targeting STATs are still in the preclinical phase. Meanwhile, curcumin, quercetin, and several kinds of plant polyphenol chemicals play roles in multiple sites of the JAK-STAT pathway to suppress abnormal activation. Polyphenol compounds have shown remarkable effects by acting on the JAK-STAT pathway in anti-inflammatory, antitumor, and cardiovascular disease control. This review summarizes the pharmacological effects of more than 20 kinds of phytochemicals on JAK-STAT signaling pathway according to the chemical structure of polyphenolic phytochemicals.
abstract_unstemmed	The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immune mechanisms. Owing to the nature of this pathway and its potential cross-epitopes with multiple alternative pathways, the long-term efficacy of monotherapy-based adaptive targeting therapy is limited, and the majority of drugs targeting STATs are still in the preclinical phase. Meanwhile, curcumin, quercetin, and several kinds of plant polyphenol chemicals play roles in multiple sites of the JAK-STAT pathway to suppress abnormal activation. Polyphenol compounds have shown remarkable effects by acting on the JAK-STAT pathway in anti-inflammatory, antitumor, and cardiovascular disease control. This review summarizes the pharmacological effects of more than 20 kinds of phytochemicals on JAK-STAT signaling pathway according to the chemical structure of polyphenolic phytochemicals.
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title_short	Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
url	https://doi.org/10.3389/fphar.2021.716672 https://doaj.org/article/e1ced3d877c9491480618dec66043d37 https://www.frontiersin.org/articles/10.3389/fphar.2021.716672/full https://doaj.org/toc/1663-9812
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Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway

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