Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis
Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expre...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wen-feng Gou [verfasserIn] Hong-zhi Sun [verfasserIn] Shuang Zhao [verfasserIn] Zhe-feng Niu [verfasserIn] Xiao-Yun Mao [verfasserIn] Yasuo Takano [verfasserIn] Hua-chuan Zheng [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
Carcinogenesis - colorectal carcinoma - ING3 - prognosis - progression |
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| Übergeordnetes Werk: |
In: Indian Journal of Medical Research - Wolters Kluwer Medknow Publications, 2005, 139(2014), 4, Seite 561-567 |
|---|---|
| Übergeordnetes Werk: |
volume:139 ; year:2014 ; number:4 ; pages:561-567 |
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| 520 | |a Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. | ||
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(DE-627)DOAJ056055455 (DE-599)DOAJd6c9bd1fccf94320909219cfb48b0f2e DE-627 ger DE-627 rakwb eng Wen-feng Gou verfasserin aut Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. Carcinogenesis - colorectal carcinoma - ING3 - prognosis - progression Medicine R Hong-zhi Sun verfasserin aut Shuang Zhao verfasserin aut Zhe-feng Niu verfasserin aut Xiao-Yun Mao verfasserin aut Yasuo Takano verfasserin aut Hua-chuan Zheng verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 139(2014), 4, Seite 561-567 (DE-627)DOAJ000026956 09715916 nnns volume:139 year:2014 number:4 pages:561-567 https://doaj.org/article/d6c9bd1fccf94320909219cfb48b0f2e kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=4;spage=561;epage=567;aulast=Gou kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 139 2014 4 561-567 |
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(DE-627)DOAJ056055455 (DE-599)DOAJd6c9bd1fccf94320909219cfb48b0f2e DE-627 ger DE-627 rakwb eng Wen-feng Gou verfasserin aut Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. Carcinogenesis - colorectal carcinoma - ING3 - prognosis - progression Medicine R Hong-zhi Sun verfasserin aut Shuang Zhao verfasserin aut Zhe-feng Niu verfasserin aut Xiao-Yun Mao verfasserin aut Yasuo Takano verfasserin aut Hua-chuan Zheng verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 139(2014), 4, Seite 561-567 (DE-627)DOAJ000026956 09715916 nnns volume:139 year:2014 number:4 pages:561-567 https://doaj.org/article/d6c9bd1fccf94320909219cfb48b0f2e kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=4;spage=561;epage=567;aulast=Gou kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 139 2014 4 561-567 |
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(DE-627)DOAJ056055455 (DE-599)DOAJd6c9bd1fccf94320909219cfb48b0f2e DE-627 ger DE-627 rakwb eng Wen-feng Gou verfasserin aut Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. Carcinogenesis - colorectal carcinoma - ING3 - prognosis - progression Medicine R Hong-zhi Sun verfasserin aut Shuang Zhao verfasserin aut Zhe-feng Niu verfasserin aut Xiao-Yun Mao verfasserin aut Yasuo Takano verfasserin aut Hua-chuan Zheng verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 139(2014), 4, Seite 561-567 (DE-627)DOAJ000026956 09715916 nnns volume:139 year:2014 number:4 pages:561-567 https://doaj.org/article/d6c9bd1fccf94320909219cfb48b0f2e kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=4;spage=561;epage=567;aulast=Gou kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 139 2014 4 561-567 |
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(DE-627)DOAJ056055455 (DE-599)DOAJd6c9bd1fccf94320909219cfb48b0f2e DE-627 ger DE-627 rakwb eng Wen-feng Gou verfasserin aut Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. Carcinogenesis - colorectal carcinoma - ING3 - prognosis - progression Medicine R Hong-zhi Sun verfasserin aut Shuang Zhao verfasserin aut Zhe-feng Niu verfasserin aut Xiao-Yun Mao verfasserin aut Yasuo Takano verfasserin aut Hua-chuan Zheng verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 139(2014), 4, Seite 561-567 (DE-627)DOAJ000026956 09715916 nnns volume:139 year:2014 number:4 pages:561-567 https://doaj.org/article/d6c9bd1fccf94320909219cfb48b0f2e kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=4;spage=561;epage=567;aulast=Gou kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 139 2014 4 561-567 |
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(DE-627)DOAJ056055455 (DE-599)DOAJd6c9bd1fccf94320909219cfb48b0f2e DE-627 ger DE-627 rakwb eng Wen-feng Gou verfasserin aut Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. Carcinogenesis - colorectal carcinoma - ING3 - prognosis - progression Medicine R Hong-zhi Sun verfasserin aut Shuang Zhao verfasserin aut Zhe-feng Niu verfasserin aut Xiao-Yun Mao verfasserin aut Yasuo Takano verfasserin aut Hua-chuan Zheng verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 139(2014), 4, Seite 561-567 (DE-627)DOAJ000026956 09715916 nnns volume:139 year:2014 number:4 pages:561-567 https://doaj.org/article/d6c9bd1fccf94320909219cfb48b0f2e kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=4;spage=561;epage=567;aulast=Gou kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 139 2014 4 561-567 |
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Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis |
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Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis |
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Wen-feng Gou |
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Indian Journal of Medical Research |
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Indian Journal of Medical Research |
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Wen-feng Gou Hong-zhi Sun Shuang Zhao Zhe-feng Niu Xiao-Yun Mao Yasuo Takano Hua-chuan Zheng |
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139 |
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Wen-feng Gou |
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verfasserin |
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downregulated inhibitor of growth 3 (ing3) expression during colorectal carcinogenesis |
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Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis |
| abstract |
Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. |
| abstractGer |
Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. |
| abstract_unstemmed |
Background & objectives: ING3 (inhibitor of growth protein 3) overexpression decreased S-phase cell population and colony-forming efficiency, and induced apoptosis at a p53-mediated manner. The aim of this study was to investigate the clinicopathological and prognostic significance of ING3 expression in colorectal carcinogenesis and subsequent progression. Methods: ING3 expression was examined by immunohistochemistry on tissue microarray containing colorectal non-neoplastic mucosa (NNM), adenoma and adenocarcinoma. Colorectal carcinoma tissue and cell lines were studied for ING3 expression by Western blot or RT-PCR. Results: ING3 mRNA was differentially expressed in Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620 and WiDr cells. Carcinomas showed significantly lower ING3 expression than matched NNM at mRNA level (P< 0.05), but not at protein level. Immunohistochemically, ING3 expression was significantly decreased from NNM, adenoma to adenocarcinoma (P< 0.05). ING3 expression was not correlated with age, sex, tumour size, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumour- node- metastasis staging or differentiation. Kaplan-Meier analysis indicated that ING3 protein expression was not associated the prognosis of the patients with colorectal carcinoma (P< 0.05). Interpretation & conclusions: Our study showed that downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. Further studies are required to understand the mechanism. |
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Downregulated inhibitor of growth 3 (ING3) expression during colorectal carcinogenesis |
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https://doaj.org/article/d6c9bd1fccf94320909219cfb48b0f2e http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=139;issue=4;spage=561;epage=567;aulast=Gou https://doaj.org/toc/0971-5916 |
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Hong-zhi Sun Shuang Zhao Zhe-feng Niu Xiao-Yun Mao Yasuo Takano Hua-chuan Zheng |
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2024-07-03T18:37:06.215Z |
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