A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections

Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect plac...
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Gespeichert in:

Autor*in:	Elena Pleteneva [verfasserIn] Sergey Krylov [verfasserIn] Olga Shaburova [verfasserIn] Victor Krylov [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage’ s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine

Übergeordnetes Werk:	In: Viruses - MDPI AG, 2009, 5(2012), 1, Seite 15-53
Übergeordnetes Werk:	volume:5 ; year:2012 ; number:1 ; pages:15-53

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/v5010015

Katalog-ID:	DOAJ056061935

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allfields	10.3390/v5010015 doi (DE-627)DOAJ056061935 (DE-599)DOAJ15c072daba2a4b228352d023e5bee682 DE-627 ger DE-627 rakwb eng QR1-502 Elena Pleteneva verfasserin aut A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine. Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage&#8217 s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine Microbiology Sergey Krylov verfasserin aut Olga Shaburova verfasserin aut Victor Krylov verfasserin aut In Viruses MDPI AG, 2009 5(2012), 1, Seite 15-53 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:5 year:2012 number:1 pages:15-53 https://doi.org/10.3390/v5010015 kostenfrei https://doaj.org/article/15c072daba2a4b228352d023e5bee682 kostenfrei http://www.mdpi.com/1999-4915/5/1/15 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 15-53
spelling	10.3390/v5010015 doi (DE-627)DOAJ056061935 (DE-599)DOAJ15c072daba2a4b228352d023e5bee682 DE-627 ger DE-627 rakwb eng QR1-502 Elena Pleteneva verfasserin aut A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine. Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage&#8217 s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine Microbiology Sergey Krylov verfasserin aut Olga Shaburova verfasserin aut Victor Krylov verfasserin aut In Viruses MDPI AG, 2009 5(2012), 1, Seite 15-53 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:5 year:2012 number:1 pages:15-53 https://doi.org/10.3390/v5010015 kostenfrei https://doaj.org/article/15c072daba2a4b228352d023e5bee682 kostenfrei http://www.mdpi.com/1999-4915/5/1/15 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 15-53
allfields_unstemmed	10.3390/v5010015 doi (DE-627)DOAJ056061935 (DE-599)DOAJ15c072daba2a4b228352d023e5bee682 DE-627 ger DE-627 rakwb eng QR1-502 Elena Pleteneva verfasserin aut A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine. Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage&#8217 s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine Microbiology Sergey Krylov verfasserin aut Olga Shaburova verfasserin aut Victor Krylov verfasserin aut In Viruses MDPI AG, 2009 5(2012), 1, Seite 15-53 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:5 year:2012 number:1 pages:15-53 https://doi.org/10.3390/v5010015 kostenfrei https://doaj.org/article/15c072daba2a4b228352d023e5bee682 kostenfrei http://www.mdpi.com/1999-4915/5/1/15 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 15-53
allfieldsGer	10.3390/v5010015 doi (DE-627)DOAJ056061935 (DE-599)DOAJ15c072daba2a4b228352d023e5bee682 DE-627 ger DE-627 rakwb eng QR1-502 Elena Pleteneva verfasserin aut A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine. Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage&#8217 s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine Microbiology Sergey Krylov verfasserin aut Olga Shaburova verfasserin aut Victor Krylov verfasserin aut In Viruses MDPI AG, 2009 5(2012), 1, Seite 15-53 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:5 year:2012 number:1 pages:15-53 https://doi.org/10.3390/v5010015 kostenfrei https://doaj.org/article/15c072daba2a4b228352d023e5bee682 kostenfrei http://www.mdpi.com/1999-4915/5/1/15 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 15-53
allfieldsSound	10.3390/v5010015 doi (DE-627)DOAJ056061935 (DE-599)DOAJ15c072daba2a4b228352d023e5bee682 DE-627 ger DE-627 rakwb eng QR1-502 Elena Pleteneva verfasserin aut A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine. Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage&#8217 s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine Microbiology Sergey Krylov verfasserin aut Olga Shaburova verfasserin aut Victor Krylov verfasserin aut In Viruses MDPI AG, 2009 5(2012), 1, Seite 15-53 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:5 year:2012 number:1 pages:15-53 https://doi.org/10.3390/v5010015 kostenfrei https://doaj.org/article/15c072daba2a4b228352d023e5bee682 kostenfrei http://www.mdpi.com/1999-4915/5/1/15 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 15-53
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topic_facet	Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage&#8217 s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine Microbiology
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author	Elena Pleteneva
spellingShingle	Elena Pleteneva misc QR1-502 misc Pseudomonas aeruginosa bacteriophages diversity misc noncanonical relations of phages and bacteria misc phage&#8217 misc s migrations misc phage genomes instability misc pseudolysogeny and pseudovirulence misc phage therapy as a kind of personalized medicine misc Microbiology A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections
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topic_title	QR1-502 A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections Pseudomonas aeruginosa bacteriophages diversity noncanonical relations of phages and bacteria phage&#8217 s migrations phage genomes instability pseudolysogeny and pseudovirulence phage therapy as a kind of personalized medicine
topic	misc QR1-502 misc Pseudomonas aeruginosa bacteriophages diversity misc noncanonical relations of phages and bacteria misc phage&#8217 misc s migrations misc phage genomes instability misc pseudolysogeny and pseudovirulence misc phage therapy as a kind of personalized medicine misc Microbiology
topic_unstemmed	misc QR1-502 misc Pseudomonas aeruginosa bacteriophages diversity misc noncanonical relations of phages and bacteria misc phage&#8217 misc s migrations misc phage genomes instability misc pseudolysogeny and pseudovirulence misc phage therapy as a kind of personalized medicine misc Microbiology
topic_browse	misc QR1-502 misc Pseudomonas aeruginosa bacteriophages diversity misc noncanonical relations of phages and bacteria misc phage&#8217 misc s migrations misc phage genomes instability misc pseudolysogeny and pseudovirulence misc phage therapy as a kind of personalized medicine misc Microbiology
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title	A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections
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title_full	A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections
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title_sort	genetic approach to the development of new therapeutic phages to fight pseudomonas aeruginosa in wound infections
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title_auth	A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections
abstract	Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine.
abstractGer	Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine.
abstract_unstemmed	Pseudomonas aeruginosa is a frequent participant in wound infections. Emergence of multiple antibiotic resistant strains has created significant problems in the treatment of infected wounds. Phage therapy (PT) has been proposed as a possible alternative approach. Infected wounds are the perfect place for PT applications, since the basic condition for PT is ensured; namely, the direct contact of bacteria and their viruses. Plenty of virulent (“lytic”) and temperate (“lysogenic”) bacteriophages are known in P. aeruginosa. However, the number of virulent phage species acceptable for PT and their mutability are limited. Besides, there are different deviations in the behavior of virulent (and temperate) phages from their expected canonical models of development. We consider some examples of non-canonical phage-bacterium interactions and the possibility of their use in PT. In addition, some optimal approaches to the development of phage therapy will be discussed from the point of view of a biologist, considering the danger of phage-assisted horizontal gene transfer (HGT), and from the point of view of a surgeon who has accepted the Hippocrates Oath to cure patients by all possible means. It is also time now to discuss the possible approaches in international cooperation for the development of PT. We think it would be advantageous to make phage therapy a kind of personalized medicine.
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title_short	A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections
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A Genetic Approach to the Development of New Therapeutic Phages to Fight Pseudomonas Aeruginosa in Wound Infections

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