A reference map of sphingolipids in murine tissues

Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics,...
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Autor*in:	Sneha Muralidharan [verfasserIn] Mitsugu Shimobayashi [verfasserIn] Shanshan Ji [verfasserIn] Bo Burla [verfasserIn] Michael N. Hall [verfasserIn] Markus R. Wenk [verfasserIn] Federico Torta [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 35(2021), 11, Seite 109250-
Übergeordnetes Werk:	volume:35 ; year:2021 ; number:11 ; pages:109250-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2021.109250

Katalog-ID:	DOAJ056115075

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allfields	10.1016/j.celrep.2021.109250 doi (DE-627)DOAJ056115075 (DE-599)DOAJ0f1b79fa29eb4c9abfe281ae0da3d90e DE-627 ger DE-627 rakwb eng QH301-705.5 Sneha Muralidharan verfasserin aut A reference map of sphingolipids in murine tissues 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease. sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet Biology (General) Mitsugu Shimobayashi verfasserin aut Shanshan Ji verfasserin aut Bo Burla verfasserin aut Michael N. Hall verfasserin aut Markus R. Wenk verfasserin aut Federico Torta verfasserin aut In Cell Reports Elsevier, 2015 35(2021), 11, Seite 109250- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:35 year:2021 number:11 pages:109250- https://doi.org/10.1016/j.celrep.2021.109250 kostenfrei https://doaj.org/article/0f1b79fa29eb4c9abfe281ae0da3d90e kostenfrei http://www.sciencedirect.com/science/article/pii/S221112472100615X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2021 11 109250-
spelling	10.1016/j.celrep.2021.109250 doi (DE-627)DOAJ056115075 (DE-599)DOAJ0f1b79fa29eb4c9abfe281ae0da3d90e DE-627 ger DE-627 rakwb eng QH301-705.5 Sneha Muralidharan verfasserin aut A reference map of sphingolipids in murine tissues 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease. sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet Biology (General) Mitsugu Shimobayashi verfasserin aut Shanshan Ji verfasserin aut Bo Burla verfasserin aut Michael N. Hall verfasserin aut Markus R. Wenk verfasserin aut Federico Torta verfasserin aut In Cell Reports Elsevier, 2015 35(2021), 11, Seite 109250- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:35 year:2021 number:11 pages:109250- https://doi.org/10.1016/j.celrep.2021.109250 kostenfrei https://doaj.org/article/0f1b79fa29eb4c9abfe281ae0da3d90e kostenfrei http://www.sciencedirect.com/science/article/pii/S221112472100615X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2021 11 109250-
allfields_unstemmed	10.1016/j.celrep.2021.109250 doi (DE-627)DOAJ056115075 (DE-599)DOAJ0f1b79fa29eb4c9abfe281ae0da3d90e DE-627 ger DE-627 rakwb eng QH301-705.5 Sneha Muralidharan verfasserin aut A reference map of sphingolipids in murine tissues 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease. sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet Biology (General) Mitsugu Shimobayashi verfasserin aut Shanshan Ji verfasserin aut Bo Burla verfasserin aut Michael N. Hall verfasserin aut Markus R. Wenk verfasserin aut Federico Torta verfasserin aut In Cell Reports Elsevier, 2015 35(2021), 11, Seite 109250- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:35 year:2021 number:11 pages:109250- https://doi.org/10.1016/j.celrep.2021.109250 kostenfrei https://doaj.org/article/0f1b79fa29eb4c9abfe281ae0da3d90e kostenfrei http://www.sciencedirect.com/science/article/pii/S221112472100615X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2021 11 109250-
allfieldsGer	10.1016/j.celrep.2021.109250 doi (DE-627)DOAJ056115075 (DE-599)DOAJ0f1b79fa29eb4c9abfe281ae0da3d90e DE-627 ger DE-627 rakwb eng QH301-705.5 Sneha Muralidharan verfasserin aut A reference map of sphingolipids in murine tissues 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease. sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet Biology (General) Mitsugu Shimobayashi verfasserin aut Shanshan Ji verfasserin aut Bo Burla verfasserin aut Michael N. Hall verfasserin aut Markus R. Wenk verfasserin aut Federico Torta verfasserin aut In Cell Reports Elsevier, 2015 35(2021), 11, Seite 109250- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:35 year:2021 number:11 pages:109250- https://doi.org/10.1016/j.celrep.2021.109250 kostenfrei https://doaj.org/article/0f1b79fa29eb4c9abfe281ae0da3d90e kostenfrei http://www.sciencedirect.com/science/article/pii/S221112472100615X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2021 11 109250-
allfieldsSound	10.1016/j.celrep.2021.109250 doi (DE-627)DOAJ056115075 (DE-599)DOAJ0f1b79fa29eb4c9abfe281ae0da3d90e DE-627 ger DE-627 rakwb eng QH301-705.5 Sneha Muralidharan verfasserin aut A reference map of sphingolipids in murine tissues 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease. sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet Biology (General) Mitsugu Shimobayashi verfasserin aut Shanshan Ji verfasserin aut Bo Burla verfasserin aut Michael N. Hall verfasserin aut Markus R. Wenk verfasserin aut Federico Torta verfasserin aut In Cell Reports Elsevier, 2015 35(2021), 11, Seite 109250- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:35 year:2021 number:11 pages:109250- https://doi.org/10.1016/j.celrep.2021.109250 kostenfrei https://doaj.org/article/0f1b79fa29eb4c9abfe281ae0da3d90e kostenfrei http://www.sciencedirect.com/science/article/pii/S221112472100615X kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2021 11 109250-
language	English
source	In Cell Reports 35(2021), 11, Seite 109250- volume:35 year:2021 number:11 pages:109250-
sourceStr	In Cell Reports 35(2021), 11, Seite 109250- volume:35 year:2021 number:11 pages:109250-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Sneha Muralidharan @@aut@@ Mitsugu Shimobayashi @@aut@@ Shanshan Ji @@aut@@ Bo Burla @@aut@@ Michael N. Hall @@aut@@ Markus R. Wenk @@aut@@ Federico Torta @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ056115075
language_de	englisch
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callnumber-first	Q - Science
author	Sneha Muralidharan
spellingShingle	Sneha Muralidharan misc QH301-705.5 misc sphingolipids misc tissue atlas misc lipidomics misc mass spectrometry misc sex-specific misc high-fat diet misc Biology (General) A reference map of sphingolipids in murine tissues
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topic_title	QH301-705.5 A reference map of sphingolipids in murine tissues sphingolipids tissue atlas lipidomics mass spectrometry sex-specific high-fat diet
topic	misc QH301-705.5 misc sphingolipids misc tissue atlas misc lipidomics misc mass spectrometry misc sex-specific misc high-fat diet misc Biology (General)
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title	A reference map of sphingolipids in murine tissues
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title_full	A reference map of sphingolipids in murine tissues
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author_browse	Sneha Muralidharan Mitsugu Shimobayashi Shanshan Ji Bo Burla Michael N. Hall Markus R. Wenk Federico Torta
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title_sort	reference map of sphingolipids in murine tissues
callnumber	QH301-705.5
title_auth	A reference map of sphingolipids in murine tissues
abstract	Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease.
abstractGer	Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease.
abstract_unstemmed	Summary: Sphingolipids (SPs) have both a structural role in the cell membranes and a signaling function that regulates many cellular processes. The enormous structural diversity and low abundance of many SPs pose a challenge for their identification and quantification. Recent advances in lipidomics, in particular liquid chromatography (LC) coupled with mass spectrometry (MS), provide methods to detect and quantify many low-abundant SP species reliably. Here we use LC-MS to compile a “murine sphingolipid atlas,” containing the qualitative and quantitative distribution of 114 SPs in 21 tissues of a widely utilized wild-type laboratory mouse strain (C57BL/6). We report tissue-specific SP fingerprints, as well as sex-specific differences in the same tissue. This is a comprehensive, quantitative sphingolipidomic map of mammalian tissues collected in a systematic fashion. It will complement other tissue compendia for interrogation into the role of SP in mammalian health and disease.
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title_short	A reference map of sphingolipids in murine tissues
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A reference map of sphingolipids in murine tissues

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