Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas

Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type am...
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Autor*in:	Ahmad Faried, MD., PhD [verfasserIn] Hendrikus M.B. Bolly, MD., PhD [verfasserIn] Yulius Hermanto, MD., PhD [verfasserIn] Arifudin Achmad, MD., PhD [verfasserIn] Danny Halim, MD., PhD [verfasserIn] Firman P. Tjahjono, MD., MSc [verfasserIn] Hasrayati Agustina, MD., PhD [verfasserIn] Achmad H.S. Kartamihardja, MD., PhD [verfasserIn] Muhammad Z. Arifin, MD., PhD [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1

Übergeordnetes Werk:	In: Interdisciplinary Neurosurgery - Elsevier, 2015, 23(2021), Seite 100939-
Übergeordnetes Werk:	volume:23 ; year:2021 ; pages:100939-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.inat.2020.100939

Katalog-ID:	DOAJ056244452

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520			\|a Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies.
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700	0		\|a Achmad H.S. Kartamihardja, MD., PhD \|e verfasserin \|4 aut
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allfields	10.1016/j.inat.2020.100939 doi (DE-627)DOAJ056244452 (DE-599)DOAJ15c8e189821147d6b5ed6975dc3520d4 DE-627 ger DE-627 rakwb eng RD1-811 RC346-429 Ahmad Faried, MD., PhD verfasserin aut Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies. Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1 Surgery Neurology. Diseases of the nervous system Hendrikus M.B. Bolly, MD., PhD verfasserin aut Yulius Hermanto, MD., PhD verfasserin aut Arifudin Achmad, MD., PhD verfasserin aut Danny Halim, MD., PhD verfasserin aut Firman P. Tjahjono, MD., MSc verfasserin aut Hasrayati Agustina, MD., PhD verfasserin aut Achmad H.S. Kartamihardja, MD., PhD verfasserin aut Muhammad Z. Arifin, MD., PhD verfasserin aut In Interdisciplinary Neurosurgery Elsevier, 2015 23(2021), Seite 100939- (DE-627)797382003 (DE-600)2785532-6 22147519 nnns volume:23 year:2021 pages:100939- https://doi.org/10.1016/j.inat.2020.100939 kostenfrei https://doaj.org/article/15c8e189821147d6b5ed6975dc3520d4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214751920305004 kostenfrei https://doaj.org/toc/2214-7519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2021 100939-
spelling	10.1016/j.inat.2020.100939 doi (DE-627)DOAJ056244452 (DE-599)DOAJ15c8e189821147d6b5ed6975dc3520d4 DE-627 ger DE-627 rakwb eng RD1-811 RC346-429 Ahmad Faried, MD., PhD verfasserin aut Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies. Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1 Surgery Neurology. Diseases of the nervous system Hendrikus M.B. Bolly, MD., PhD verfasserin aut Yulius Hermanto, MD., PhD verfasserin aut Arifudin Achmad, MD., PhD verfasserin aut Danny Halim, MD., PhD verfasserin aut Firman P. Tjahjono, MD., MSc verfasserin aut Hasrayati Agustina, MD., PhD verfasserin aut Achmad H.S. Kartamihardja, MD., PhD verfasserin aut Muhammad Z. Arifin, MD., PhD verfasserin aut In Interdisciplinary Neurosurgery Elsevier, 2015 23(2021), Seite 100939- (DE-627)797382003 (DE-600)2785532-6 22147519 nnns volume:23 year:2021 pages:100939- https://doi.org/10.1016/j.inat.2020.100939 kostenfrei https://doaj.org/article/15c8e189821147d6b5ed6975dc3520d4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214751920305004 kostenfrei https://doaj.org/toc/2214-7519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2021 100939-
allfields_unstemmed	10.1016/j.inat.2020.100939 doi (DE-627)DOAJ056244452 (DE-599)DOAJ15c8e189821147d6b5ed6975dc3520d4 DE-627 ger DE-627 rakwb eng RD1-811 RC346-429 Ahmad Faried, MD., PhD verfasserin aut Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies. Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1 Surgery Neurology. Diseases of the nervous system Hendrikus M.B. Bolly, MD., PhD verfasserin aut Yulius Hermanto, MD., PhD verfasserin aut Arifudin Achmad, MD., PhD verfasserin aut Danny Halim, MD., PhD verfasserin aut Firman P. Tjahjono, MD., MSc verfasserin aut Hasrayati Agustina, MD., PhD verfasserin aut Achmad H.S. Kartamihardja, MD., PhD verfasserin aut Muhammad Z. Arifin, MD., PhD verfasserin aut In Interdisciplinary Neurosurgery Elsevier, 2015 23(2021), Seite 100939- (DE-627)797382003 (DE-600)2785532-6 22147519 nnns volume:23 year:2021 pages:100939- https://doi.org/10.1016/j.inat.2020.100939 kostenfrei https://doaj.org/article/15c8e189821147d6b5ed6975dc3520d4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214751920305004 kostenfrei https://doaj.org/toc/2214-7519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2021 100939-
allfieldsGer	10.1016/j.inat.2020.100939 doi (DE-627)DOAJ056244452 (DE-599)DOAJ15c8e189821147d6b5ed6975dc3520d4 DE-627 ger DE-627 rakwb eng RD1-811 RC346-429 Ahmad Faried, MD., PhD verfasserin aut Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies. Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1 Surgery Neurology. Diseases of the nervous system Hendrikus M.B. Bolly, MD., PhD verfasserin aut Yulius Hermanto, MD., PhD verfasserin aut Arifudin Achmad, MD., PhD verfasserin aut Danny Halim, MD., PhD verfasserin aut Firman P. Tjahjono, MD., MSc verfasserin aut Hasrayati Agustina, MD., PhD verfasserin aut Achmad H.S. Kartamihardja, MD., PhD verfasserin aut Muhammad Z. Arifin, MD., PhD verfasserin aut In Interdisciplinary Neurosurgery Elsevier, 2015 23(2021), Seite 100939- (DE-627)797382003 (DE-600)2785532-6 22147519 nnns volume:23 year:2021 pages:100939- https://doi.org/10.1016/j.inat.2020.100939 kostenfrei https://doaj.org/article/15c8e189821147d6b5ed6975dc3520d4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214751920305004 kostenfrei https://doaj.org/toc/2214-7519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2021 100939-
allfieldsSound	10.1016/j.inat.2020.100939 doi (DE-627)DOAJ056244452 (DE-599)DOAJ15c8e189821147d6b5ed6975dc3520d4 DE-627 ger DE-627 rakwb eng RD1-811 RC346-429 Ahmad Faried, MD., PhD verfasserin aut Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies. Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1 Surgery Neurology. Diseases of the nervous system Hendrikus M.B. Bolly, MD., PhD verfasserin aut Yulius Hermanto, MD., PhD verfasserin aut Arifudin Achmad, MD., PhD verfasserin aut Danny Halim, MD., PhD verfasserin aut Firman P. Tjahjono, MD., MSc verfasserin aut Hasrayati Agustina, MD., PhD verfasserin aut Achmad H.S. Kartamihardja, MD., PhD verfasserin aut Muhammad Z. Arifin, MD., PhD verfasserin aut In Interdisciplinary Neurosurgery Elsevier, 2015 23(2021), Seite 100939- (DE-627)797382003 (DE-600)2785532-6 22147519 nnns volume:23 year:2021 pages:100939- https://doi.org/10.1016/j.inat.2020.100939 kostenfrei https://doaj.org/article/15c8e189821147d6b5ed6975dc3520d4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2214751920305004 kostenfrei https://doaj.org/toc/2214-7519 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2021 100939-
language	English
source	In Interdisciplinary Neurosurgery 23(2021), Seite 100939- volume:23 year:2021 pages:100939-
sourceStr	In Interdisciplinary Neurosurgery 23(2021), Seite 100939- volume:23 year:2021 pages:100939-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1 Surgery Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	Interdisciplinary Neurosurgery
authorswithroles_txt_mv	Ahmad Faried, MD., PhD @@aut@@ Hendrikus M.B. Bolly, MD., PhD @@aut@@ Yulius Hermanto, MD., PhD @@aut@@ Arifudin Achmad, MD., PhD @@aut@@ Danny Halim, MD., PhD @@aut@@ Firman P. Tjahjono, MD., MSc @@aut@@ Hasrayati Agustina, MD., PhD @@aut@@ Achmad H.S. Kartamihardja, MD., PhD @@aut@@ Muhammad Z. Arifin, MD., PhD @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	797382003
id	DOAJ056244452
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ056244452</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308200139.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.inat.2020.100939</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ056244452</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ15c8e189821147d6b5ed6975dc3520d4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RD1-811</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC346-429</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Ahmad Faried, MD., PhD</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). 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callnumber-first	R - Medicine
author	Ahmad Faried, MD., PhD
spellingShingle	Ahmad Faried, MD., PhD misc RD1-811 misc RC346-429 misc Human astrocytic gliomas misc IDH1 R132H mutant misc Ki-67 misc PD-L1 misc LAT-1 misc Surgery misc Neurology. Diseases of the nervous system Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas
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topic_title	RD1-811 RC346-429 Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas Human astrocytic gliomas IDH1 R132H mutant Ki-67 PD-L1 LAT-1
topic	misc RD1-811 misc RC346-429 misc Human astrocytic gliomas misc IDH1 R132H mutant misc Ki-67 misc PD-L1 misc LAT-1 misc Surgery misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RD1-811 misc RC346-429 misc Human astrocytic gliomas misc IDH1 R132H mutant misc Ki-67 misc PD-L1 misc LAT-1 misc Surgery misc Neurology. Diseases of the nervous system
topic_browse	misc RD1-811 misc RC346-429 misc Human astrocytic gliomas misc IDH1 R132H mutant misc Ki-67 misc PD-L1 misc LAT-1 misc Surgery misc Neurology. Diseases of the nervous system
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title	Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas
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title_full	Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas
author_sort	Ahmad Faried, MD., PhD
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author_browse	Ahmad Faried, MD., PhD Hendrikus M.B. Bolly, MD., PhD Yulius Hermanto, MD., PhD Arifudin Achmad, MD., PhD Danny Halim, MD., PhD Firman P. Tjahjono, MD., MSc Hasrayati Agustina, MD., PhD Achmad H.S. Kartamihardja, MD., PhD Muhammad Z. Arifin, MD., PhD
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author-letter	Ahmad Faried, MD., PhD
doi_str_mv	10.1016/j.inat.2020.100939
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title_sort	prognostic significance of l-type amino acid transporter-1 (lat-1) expression in human astrocytic gliomas
callnumber	RD1-811
title_auth	Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas
abstract	Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies.
abstractGer	Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies.
abstract_unstemmed	Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. Therefore, LAT-1 and PD-L1 examination is potentially valuable diagnostic markers for adjuvant therapies.
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title_short	Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas
url	https://doi.org/10.1016/j.inat.2020.100939 https://doaj.org/article/15c8e189821147d6b5ed6975dc3520d4 http://www.sciencedirect.com/science/article/pii/S2214751920305004 https://doaj.org/toc/2214-7519
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author2	Hendrikus M.B. Bolly, MD., PhD Yulius Hermanto, MD., PhD Arifudin Achmad, MD., PhD Danny Halim, MD., PhD Firman P. Tjahjono, MD., MSc Hasrayati Agustina, MD., PhD Achmad H.S. Kartamihardja, MD., PhD Muhammad Z. Arifin, MD., PhD
author2Str	Hendrikus M.B. Bolly, MD., PhD Yulius Hermanto, MD., PhD Arifudin Achmad, MD., PhD Danny Halim, MD., PhD Firman P. Tjahjono, MD., MSc Hasrayati Agustina, MD., PhD Achmad H.S. Kartamihardja, MD., PhD Muhammad Z. Arifin, MD., PhD
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up_date	2024-07-03T19:43:24.240Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ056244452</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308200139.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.inat.2020.100939</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ056244452</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ15c8e189821147d6b5ed6975dc3520d4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RD1-811</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC346-429</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Ahmad Faried, MD., PhD</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Gliomas are the most prevalent type of primary brain tumors. Clarifying the correlation between glioma markers and disease progression provide a basis for adjuvant treatments. We examined Isocitrate dehydrogenase 1 (IDH1) expression, Ki-67, programmed death-ligand 1 (PD-L1) and L-type amino acid transporter 1 (LAT-1) with respect to overall survival in glioma patients. Methods: Immunohistochemistry (IHC) results from 25 glioma samples were analyzed semi-quantitatively. By WHO criteria, eleven specimens were diagnosed as grade II, 7 as grade III, and 7 as grade IV. Grade II was classified as lower grade glioma (LGG); grade III-IV were classified as high grade glioma (HGG). Results: In this study, immuno-characterization revealed HGG was associated with high Ki-67, PD-L1, and LAT-1 expression (p < 0.05), but not with IDH1 R132H mutant expression (p = 0.6217). Both LAT-1 and PD-L1 were associated with Ki-67 expression (p < 0.05). LAT-1 was found to be correlated with PD-L1 expression (r = 0.525, p = 0.007). Upon, multivariate analysis, LAT-1 expression in human astrocytic gliomas was meaningful as an independent prognosis factor (HR = 0.004 (0.00004–0.41)). Conclusion: LAT-1 and PD-L1 expression by HGG contribute to the disease progression. LAT-1 expression in astrocytic gliomas serves an independent prognosis factor. 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Prognostic significance of L-type amino acid transporter-1 (LAT-1) expression in human astrocytic gliomas

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