Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications

Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, re...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ángela Bella [verfasserIn] Claudia Augusta Di Trani [verfasserIn] Myriam Fernández-Sendin [verfasserIn] Leire Arrizabalaga [verfasserIn] Assunta Cirella [verfasserIn] Álvaro Teijeira [verfasserIn] José Medina-Echeverz [verfasserIn] Ignacio Melero [verfasserIn] Pedro Berraondo [verfasserIn] Fernando Aranda [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	peritoneal carcinomatosis animal model translational research peritoneal microenvironment metastasis

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 5, p 963
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:5, p 963

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13050963

Katalog-ID:	DOAJ056250614

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spelling	10.3390/cancers13050963 doi (DE-627)DOAJ056250614 (DE-599)DOAJ9924aa84a0c84c5887264b52efbe6ebb DE-627 ger DE-627 rakwb eng RC254-282 Ángela Bella verfasserin aut Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents. peritoneal carcinomatosis animal model translational research peritoneal microenvironment metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Augusta Di Trani verfasserin aut Myriam Fernández-Sendin verfasserin aut Leire Arrizabalaga verfasserin aut Assunta Cirella verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In Cancers MDPI AG, 2010 13(2021), 5, p 963 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:5, p 963 https://doi.org/10.3390/cancers13050963 kostenfrei https://doaj.org/article/9924aa84a0c84c5887264b52efbe6ebb kostenfrei https://www.mdpi.com/2072-6694/13/5/963 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 5, p 963
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allfieldsGer	10.3390/cancers13050963 doi (DE-627)DOAJ056250614 (DE-599)DOAJ9924aa84a0c84c5887264b52efbe6ebb DE-627 ger DE-627 rakwb eng RC254-282 Ángela Bella verfasserin aut Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents. peritoneal carcinomatosis animal model translational research peritoneal microenvironment metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Augusta Di Trani verfasserin aut Myriam Fernández-Sendin verfasserin aut Leire Arrizabalaga verfasserin aut Assunta Cirella verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In Cancers MDPI AG, 2010 13(2021), 5, p 963 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:5, p 963 https://doi.org/10.3390/cancers13050963 kostenfrei https://doaj.org/article/9924aa84a0c84c5887264b52efbe6ebb kostenfrei https://www.mdpi.com/2072-6694/13/5/963 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 5, p 963
allfieldsSound	10.3390/cancers13050963 doi (DE-627)DOAJ056250614 (DE-599)DOAJ9924aa84a0c84c5887264b52efbe6ebb DE-627 ger DE-627 rakwb eng RC254-282 Ángela Bella verfasserin aut Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents. peritoneal carcinomatosis animal model translational research peritoneal microenvironment metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Augusta Di Trani verfasserin aut Myriam Fernández-Sendin verfasserin aut Leire Arrizabalaga verfasserin aut Assunta Cirella verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In Cancers MDPI AG, 2010 13(2021), 5, p 963 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:5, p 963 https://doi.org/10.3390/cancers13050963 kostenfrei https://doaj.org/article/9924aa84a0c84c5887264b52efbe6ebb kostenfrei https://www.mdpi.com/2072-6694/13/5/963 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 5, p 963
language	English
source	In Cancers 13(2021), 5, p 963 volume:13 year:2021 number:5, p 963
sourceStr	In Cancers 13(2021), 5, p 963 volume:13 year:2021 number:5, p 963
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	peritoneal carcinomatosis animal model translational research peritoneal microenvironment metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Ángela Bella @@aut@@ Claudia Augusta Di Trani @@aut@@ Myriam Fernández-Sendin @@aut@@ Leire Arrizabalaga @@aut@@ Assunta Cirella @@aut@@ Álvaro Teijeira @@aut@@ José Medina-Echeverz @@aut@@ Ignacio Melero @@aut@@ Pedro Berraondo @@aut@@ Fernando Aranda @@aut@@
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callnumber-first	R - Medicine
author	Ángela Bella
spellingShingle	Ángela Bella misc RC254-282 misc peritoneal carcinomatosis misc animal model misc translational research misc peritoneal microenvironment misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications
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topic_title	RC254-282 Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications peritoneal carcinomatosis animal model translational research peritoneal microenvironment metastasis
topic	misc RC254-282 misc peritoneal carcinomatosis misc animal model misc translational research misc peritoneal microenvironment misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc peritoneal carcinomatosis misc animal model misc translational research misc peritoneal microenvironment misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc peritoneal carcinomatosis misc animal model misc translational research misc peritoneal microenvironment misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications
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author_browse	Ángela Bella Claudia Augusta Di Trani Myriam Fernández-Sendin Leire Arrizabalaga Assunta Cirella Álvaro Teijeira José Medina-Echeverz Ignacio Melero Pedro Berraondo Fernando Aranda
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title_sort	mouse models of peritoneal carcinomatosis to develop clinical applications
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title_auth	Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications
abstract	Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents.
abstractGer	Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents.
abstract_unstemmed	Peritoneal carcinomatosis of primary tumors originating in gastrointestinal (e.g., colorectal cancer, gastric cancer) or gynecologic (e.g., ovarian cancer) malignancies is a widespread type of tumor dissemination in the peritoneal cavity for which few therapeutic options are available. Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents.
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title_short	Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications
url	https://doi.org/10.3390/cancers13050963 https://doaj.org/article/9924aa84a0c84c5887264b52efbe6ebb https://www.mdpi.com/2072-6694/13/5/963 https://doaj.org/toc/2072-6694
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author2	Claudia Augusta Di Trani Myriam Fernández-Sendin Leire Arrizabalaga Assunta Cirella Álvaro Teijeira José Medina-Echeverz Ignacio Melero Pedro Berraondo Fernando Aranda
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