Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed

Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated dom...
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Autor*in:	Lasse Randers [verfasserIn] Jens Richardt Møllegaard Jepsen [verfasserIn] Birgitte Fagerlund [verfasserIn] Dorte Nordholm [verfasserIn] Kristine Krakauer [verfasserIn] Carsten Hjorthøj [verfasserIn] Birte Glenthøj [verfasserIn] Merete Nordentoft [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	at‐risk mental state clinical high risk cognition neuropsychology schizophrenia

Übergeordnetes Werk:	In: Brain and Behavior - Wiley, 2012, 11(2021), 3, Seite n/a-n/a
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:3 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/brb3.1962

Katalog-ID:	DOAJ056465386

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520			\|a Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target.
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700	0		\|a Kristine Krakauer \|e verfasserin \|4 aut
700	0		\|a Carsten Hjorthøj \|e verfasserin \|4 aut
700	0		\|a Birte Glenthøj \|e verfasserin \|4 aut
700	0		\|a Merete Nordentoft \|e verfasserin \|4 aut
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allfields	10.1002/brb3.1962 doi (DE-627)DOAJ056465386 (DE-599)DOAJ332e81dbf8fe4b33b36d3db500b99bf4 DE-627 ger DE-627 rakwb eng RC321-571 Lasse Randers verfasserin aut Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target. at‐risk mental state clinical high risk cognition neuropsychology schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry Jens Richardt Møllegaard Jepsen verfasserin aut Birgitte Fagerlund verfasserin aut Dorte Nordholm verfasserin aut Kristine Krakauer verfasserin aut Carsten Hjorthøj verfasserin aut Birte Glenthøj verfasserin aut Merete Nordentoft verfasserin aut In Brain and Behavior Wiley, 2012 11(2021), 3, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:11 year:2021 number:3 pages:n/a-n/a https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/article/332e81dbf8fe4b33b36d3db500b99bf4 kostenfrei https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 3 n/a-n/a
spelling	10.1002/brb3.1962 doi (DE-627)DOAJ056465386 (DE-599)DOAJ332e81dbf8fe4b33b36d3db500b99bf4 DE-627 ger DE-627 rakwb eng RC321-571 Lasse Randers verfasserin aut Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target. at‐risk mental state clinical high risk cognition neuropsychology schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry Jens Richardt Møllegaard Jepsen verfasserin aut Birgitte Fagerlund verfasserin aut Dorte Nordholm verfasserin aut Kristine Krakauer verfasserin aut Carsten Hjorthøj verfasserin aut Birte Glenthøj verfasserin aut Merete Nordentoft verfasserin aut In Brain and Behavior Wiley, 2012 11(2021), 3, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:11 year:2021 number:3 pages:n/a-n/a https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/article/332e81dbf8fe4b33b36d3db500b99bf4 kostenfrei https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 3 n/a-n/a
allfields_unstemmed	10.1002/brb3.1962 doi (DE-627)DOAJ056465386 (DE-599)DOAJ332e81dbf8fe4b33b36d3db500b99bf4 DE-627 ger DE-627 rakwb eng RC321-571 Lasse Randers verfasserin aut Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target. at‐risk mental state clinical high risk cognition neuropsychology schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry Jens Richardt Møllegaard Jepsen verfasserin aut Birgitte Fagerlund verfasserin aut Dorte Nordholm verfasserin aut Kristine Krakauer verfasserin aut Carsten Hjorthøj verfasserin aut Birte Glenthøj verfasserin aut Merete Nordentoft verfasserin aut In Brain and Behavior Wiley, 2012 11(2021), 3, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:11 year:2021 number:3 pages:n/a-n/a https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/article/332e81dbf8fe4b33b36d3db500b99bf4 kostenfrei https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 3 n/a-n/a
allfieldsGer	10.1002/brb3.1962 doi (DE-627)DOAJ056465386 (DE-599)DOAJ332e81dbf8fe4b33b36d3db500b99bf4 DE-627 ger DE-627 rakwb eng RC321-571 Lasse Randers verfasserin aut Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target. at‐risk mental state clinical high risk cognition neuropsychology schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry Jens Richardt Møllegaard Jepsen verfasserin aut Birgitte Fagerlund verfasserin aut Dorte Nordholm verfasserin aut Kristine Krakauer verfasserin aut Carsten Hjorthøj verfasserin aut Birte Glenthøj verfasserin aut Merete Nordentoft verfasserin aut In Brain and Behavior Wiley, 2012 11(2021), 3, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:11 year:2021 number:3 pages:n/a-n/a https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/article/332e81dbf8fe4b33b36d3db500b99bf4 kostenfrei https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 3 n/a-n/a
allfieldsSound	10.1002/brb3.1962 doi (DE-627)DOAJ056465386 (DE-599)DOAJ332e81dbf8fe4b33b36d3db500b99bf4 DE-627 ger DE-627 rakwb eng RC321-571 Lasse Randers verfasserin aut Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target. at‐risk mental state clinical high risk cognition neuropsychology schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry Jens Richardt Møllegaard Jepsen verfasserin aut Birgitte Fagerlund verfasserin aut Dorte Nordholm verfasserin aut Kristine Krakauer verfasserin aut Carsten Hjorthøj verfasserin aut Birte Glenthøj verfasserin aut Merete Nordentoft verfasserin aut In Brain and Behavior Wiley, 2012 11(2021), 3, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:11 year:2021 number:3 pages:n/a-n/a https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/article/332e81dbf8fe4b33b36d3db500b99bf4 kostenfrei https://doi.org/10.1002/brb3.1962 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 3 n/a-n/a
language	English
source	In Brain and Behavior 11(2021), 3, Seite n/a-n/a volume:11 year:2021 number:3 pages:n/a-n/a
sourceStr	In Brain and Behavior 11(2021), 3, Seite n/a-n/a volume:11 year:2021 number:3 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	at‐risk mental state clinical high risk cognition neuropsychology schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Brain and Behavior
authorswithroles_txt_mv	Lasse Randers @@aut@@ Jens Richardt Møllegaard Jepsen @@aut@@ Birgitte Fagerlund @@aut@@ Dorte Nordholm @@aut@@ Kristine Krakauer @@aut@@ Carsten Hjorthøj @@aut@@ Birte Glenthøj @@aut@@ Merete Nordentoft @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	66684805X
id	DOAJ056465386
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ056465386</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308201736.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/brb3.1962</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ056465386</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ332e81dbf8fe4b33b36d3db500b99bf4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC321-571</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Lasse Randers</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). 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callnumber-first	R - Medicine
author	Lasse Randers
spellingShingle	Lasse Randers misc RC321-571 misc at‐risk mental state misc clinical high risk misc cognition misc neuropsychology misc schizophrenia misc Neurosciences. Biological psychiatry. Neuropsychiatry Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed
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topic_title	RC321-571 Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed at‐risk mental state clinical high risk cognition neuropsychology schizophrenia
topic	misc RC321-571 misc at‐risk mental state misc clinical high risk misc cognition misc neuropsychology misc schizophrenia misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc at‐risk mental state misc clinical high risk misc cognition misc neuropsychology misc schizophrenia misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed
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title_full	Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed
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author_browse	Lasse Randers Jens Richardt Møllegaard Jepsen Birgitte Fagerlund Dorte Nordholm Kristine Krakauer Carsten Hjorthøj Birte Glenthøj Merete Nordentoft
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title_sort	generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: the possible key role of slowed processing speed
callnumber	RC321-571
title_auth	Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed
abstract	Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target.
abstractGer	Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target.
abstract_unstemmed	Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). Conclusion Slowed processing speed may underlie generalized neurocognitive impairment in UHR individuals and represent a potential intervention target.
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title_short	Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed
url	https://doi.org/10.1002/brb3.1962 https://doaj.org/article/332e81dbf8fe4b33b36d3db500b99bf4 https://doaj.org/toc/2162-3279
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ056465386</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308201736.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/brb3.1962</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ056465386</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ332e81dbf8fe4b33b36d3db500b99bf4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC321-571</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Lasse Randers</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Objective Widespread neurocognitive impairment is well‐established in individuals at ultra‐high risk (UHR) for developing psychoses, but it is unknown whether slowed processing speed may underlie impairment in other neurocognitive domains, as found in schizophrenia. The study delineated domain functioning in a UHR sample and examined if neurocognitive slowing might account for deficits across domains. Methods The cross‐sectional study included 50 UHR individuals with no (n = 38) or minimal antipsychotic exposure (n = 12; mean lifetime dose of haloperidol equivalent = 17.56 mg; SD = 13.04) and 50 matched healthy controls. Primary analyses compared group performance across neurocognitive domains before and after covarying for processing speed. To examine the specificity of processing speed effects, post hoc analyses examined the impact of the other neurocognitive domains and intelligence as covariates. Results UHR individuals exhibited significant impairment across all neurocognitive domains (all ps ≤ .010), with medium to large effect sizes (Cohen's ds = −0.53 to −1.12). Only processing speed used as covariate eliminated significant between‐group differences in all other domains, reducing unadjusted Cohen's d values with 68% on average, whereas the other domains used as covariates averagely reduced unadjusted Cohen's d values with 20% to 48%. When covarying each of the other domains after their shared variance with speed of processing was removed, all significant between‐group domain differences remained (all ps ≤ .024). 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Generalized neurocognitive impairment in individuals at ultra‐high risk for psychosis: The possible key role of slowed processing speed

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