DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors
PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in ma...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
David Westergaard [verfasserIn] Piotr Jaroslaw Chmura [verfasserIn] Kaspar Nielsen [verfasserIn] Lise Thørner [verfasserIn] Henrik Hjalgrim [verfasserIn] Helene Paarup [verfasserIn] Margit Anita Hørup Larsen [verfasserIn] Mikkel Petersen [verfasserIn] Poul Jennum [verfasserIn] Steffen Andersen [verfasserIn] Mette Nyegaard [verfasserIn] Gregor Borut Ernst Jemec [verfasserIn] Thomas Werge [verfasserIn] Pär I Johansson [verfasserIn] Erik Sørensen [verfasserIn] Kristoffer Sølvsten Burgdorf [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Übergeordnetes Werk: |
In: BMJ Open - BMJ Publishing Group, 2011, 9(2019), 6 |
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| Übergeordnetes Werk: |
volume:9 ; year:2019 ; number:6 |
| Links: |
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| DOI / URN: |
10.1136/bmjopen-2018-028401 |
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| Katalog-ID: |
DOAJ056528892 |
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| 520 | |a PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. | ||
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10.1136/bmjopen-2018-028401 doi (DE-627)DOAJ056528892 (DE-599)DOAJ87b0a763dc0842978b871f06d040da92 DE-627 ger DE-627 rakwb eng David Westergaard verfasserin aut DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. Medicine R Piotr Jaroslaw Chmura verfasserin aut Kaspar Nielsen verfasserin aut Lise Thørner verfasserin aut Henrik Hjalgrim verfasserin aut Helene Paarup verfasserin aut Margit Anita Hørup Larsen verfasserin aut Mikkel Petersen verfasserin aut Poul Jennum verfasserin aut Steffen Andersen verfasserin aut Mette Nyegaard verfasserin aut Gregor Borut Ernst Jemec verfasserin aut Thomas Werge verfasserin aut Pär I Johansson verfasserin aut Erik Sørensen verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut In BMJ Open BMJ Publishing Group, 2011 9(2019), 6 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:9 year:2019 number:6 https://doi.org/10.1136/bmjopen-2018-028401 kostenfrei https://doaj.org/article/87b0a763dc0842978b871f06d040da92 kostenfrei https://bmjopen.bmj.com/content/9/6/e028401.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 6 |
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10.1136/bmjopen-2018-028401 doi (DE-627)DOAJ056528892 (DE-599)DOAJ87b0a763dc0842978b871f06d040da92 DE-627 ger DE-627 rakwb eng David Westergaard verfasserin aut DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. Medicine R Piotr Jaroslaw Chmura verfasserin aut Kaspar Nielsen verfasserin aut Lise Thørner verfasserin aut Henrik Hjalgrim verfasserin aut Helene Paarup verfasserin aut Margit Anita Hørup Larsen verfasserin aut Mikkel Petersen verfasserin aut Poul Jennum verfasserin aut Steffen Andersen verfasserin aut Mette Nyegaard verfasserin aut Gregor Borut Ernst Jemec verfasserin aut Thomas Werge verfasserin aut Pär I Johansson verfasserin aut Erik Sørensen verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut In BMJ Open BMJ Publishing Group, 2011 9(2019), 6 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:9 year:2019 number:6 https://doi.org/10.1136/bmjopen-2018-028401 kostenfrei https://doaj.org/article/87b0a763dc0842978b871f06d040da92 kostenfrei https://bmjopen.bmj.com/content/9/6/e028401.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 6 |
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10.1136/bmjopen-2018-028401 doi (DE-627)DOAJ056528892 (DE-599)DOAJ87b0a763dc0842978b871f06d040da92 DE-627 ger DE-627 rakwb eng David Westergaard verfasserin aut DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. Medicine R Piotr Jaroslaw Chmura verfasserin aut Kaspar Nielsen verfasserin aut Lise Thørner verfasserin aut Henrik Hjalgrim verfasserin aut Helene Paarup verfasserin aut Margit Anita Hørup Larsen verfasserin aut Mikkel Petersen verfasserin aut Poul Jennum verfasserin aut Steffen Andersen verfasserin aut Mette Nyegaard verfasserin aut Gregor Borut Ernst Jemec verfasserin aut Thomas Werge verfasserin aut Pär I Johansson verfasserin aut Erik Sørensen verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut In BMJ Open BMJ Publishing Group, 2011 9(2019), 6 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:9 year:2019 number:6 https://doi.org/10.1136/bmjopen-2018-028401 kostenfrei https://doaj.org/article/87b0a763dc0842978b871f06d040da92 kostenfrei https://bmjopen.bmj.com/content/9/6/e028401.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 6 |
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10.1136/bmjopen-2018-028401 doi (DE-627)DOAJ056528892 (DE-599)DOAJ87b0a763dc0842978b871f06d040da92 DE-627 ger DE-627 rakwb eng David Westergaard verfasserin aut DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. Medicine R Piotr Jaroslaw Chmura verfasserin aut Kaspar Nielsen verfasserin aut Lise Thørner verfasserin aut Henrik Hjalgrim verfasserin aut Helene Paarup verfasserin aut Margit Anita Hørup Larsen verfasserin aut Mikkel Petersen verfasserin aut Poul Jennum verfasserin aut Steffen Andersen verfasserin aut Mette Nyegaard verfasserin aut Gregor Borut Ernst Jemec verfasserin aut Thomas Werge verfasserin aut Pär I Johansson verfasserin aut Erik Sørensen verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut In BMJ Open BMJ Publishing Group, 2011 9(2019), 6 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:9 year:2019 number:6 https://doi.org/10.1136/bmjopen-2018-028401 kostenfrei https://doaj.org/article/87b0a763dc0842978b871f06d040da92 kostenfrei https://bmjopen.bmj.com/content/9/6/e028401.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 6 |
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10.1136/bmjopen-2018-028401 doi (DE-627)DOAJ056528892 (DE-599)DOAJ87b0a763dc0842978b871f06d040da92 DE-627 ger DE-627 rakwb eng David Westergaard verfasserin aut DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. Medicine R Piotr Jaroslaw Chmura verfasserin aut Kaspar Nielsen verfasserin aut Lise Thørner verfasserin aut Henrik Hjalgrim verfasserin aut Helene Paarup verfasserin aut Margit Anita Hørup Larsen verfasserin aut Mikkel Petersen verfasserin aut Poul Jennum verfasserin aut Steffen Andersen verfasserin aut Mette Nyegaard verfasserin aut Gregor Borut Ernst Jemec verfasserin aut Thomas Werge verfasserin aut Pär I Johansson verfasserin aut Erik Sørensen verfasserin aut Kristoffer Sølvsten Burgdorf verfasserin aut In BMJ Open BMJ Publishing Group, 2011 9(2019), 6 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:9 year:2019 number:6 https://doi.org/10.1136/bmjopen-2018-028401 kostenfrei https://doaj.org/article/87b0a763dc0842978b871f06d040da92 kostenfrei https://bmjopen.bmj.com/content/9/6/e028401.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 6 |
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DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors |
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PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. |
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PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. |
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PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ056528892</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502141034.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1136/bmjopen-2018-028401</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ056528892</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ87b0a763dc0842978b871f06d040da92</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">David Westergaard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Piotr Jaroslaw Chmura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kaspar Nielsen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield 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