Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS)

<b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Neil K. Huang [verfasserIn] Petra Bůžková [verfasserIn] Nirupa R. Matthan [verfasserIn] Luc Djoussé [verfasserIn] Jorge R. Kizer [verfasserIn] Kenneth J. Mukamal [verfasserIn] Joseph F. Polak [verfasserIn] Alice H. Lichtenstein [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 13(2021), 9, p 3052
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:9, p 3052

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu13093052

Katalog-ID:	DOAJ056586973

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520			\|a <b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy.
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allfields	10.3390/nu13093052 doi (DE-627)DOAJ056586973 (DE-599)DOAJa8ed26ddf29a4c978909e531902ee3a6 DE-627 ger DE-627 rakwb eng TX341-641 Neil K. Huang verfasserin aut Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy. serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study Nutrition. Foods and food supply Petra Bůžková verfasserin aut Nirupa R. Matthan verfasserin aut Luc Djoussé verfasserin aut Jorge R. Kizer verfasserin aut Kenneth J. Mukamal verfasserin aut Joseph F. Polak verfasserin aut Alice H. Lichtenstein verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 9, p 3052 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:9, p 3052 https://doi.org/10.3390/nu13093052 kostenfrei https://doaj.org/article/a8ed26ddf29a4c978909e531902ee3a6 kostenfrei https://www.mdpi.com/2072-6643/13/9/3052 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 9, p 3052
spelling	10.3390/nu13093052 doi (DE-627)DOAJ056586973 (DE-599)DOAJa8ed26ddf29a4c978909e531902ee3a6 DE-627 ger DE-627 rakwb eng TX341-641 Neil K. Huang verfasserin aut Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy. serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study Nutrition. Foods and food supply Petra Bůžková verfasserin aut Nirupa R. Matthan verfasserin aut Luc Djoussé verfasserin aut Jorge R. Kizer verfasserin aut Kenneth J. Mukamal verfasserin aut Joseph F. Polak verfasserin aut Alice H. Lichtenstein verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 9, p 3052 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:9, p 3052 https://doi.org/10.3390/nu13093052 kostenfrei https://doaj.org/article/a8ed26ddf29a4c978909e531902ee3a6 kostenfrei https://www.mdpi.com/2072-6643/13/9/3052 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 9, p 3052
allfields_unstemmed	10.3390/nu13093052 doi (DE-627)DOAJ056586973 (DE-599)DOAJa8ed26ddf29a4c978909e531902ee3a6 DE-627 ger DE-627 rakwb eng TX341-641 Neil K. Huang verfasserin aut Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy. serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study Nutrition. Foods and food supply Petra Bůžková verfasserin aut Nirupa R. Matthan verfasserin aut Luc Djoussé verfasserin aut Jorge R. Kizer verfasserin aut Kenneth J. Mukamal verfasserin aut Joseph F. Polak verfasserin aut Alice H. Lichtenstein verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 9, p 3052 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:9, p 3052 https://doi.org/10.3390/nu13093052 kostenfrei https://doaj.org/article/a8ed26ddf29a4c978909e531902ee3a6 kostenfrei https://www.mdpi.com/2072-6643/13/9/3052 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 9, p 3052
allfieldsGer	10.3390/nu13093052 doi (DE-627)DOAJ056586973 (DE-599)DOAJa8ed26ddf29a4c978909e531902ee3a6 DE-627 ger DE-627 rakwb eng TX341-641 Neil K. Huang verfasserin aut Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy. serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study Nutrition. Foods and food supply Petra Bůžková verfasserin aut Nirupa R. Matthan verfasserin aut Luc Djoussé verfasserin aut Jorge R. Kizer verfasserin aut Kenneth J. Mukamal verfasserin aut Joseph F. Polak verfasserin aut Alice H. Lichtenstein verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 9, p 3052 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:9, p 3052 https://doi.org/10.3390/nu13093052 kostenfrei https://doaj.org/article/a8ed26ddf29a4c978909e531902ee3a6 kostenfrei https://www.mdpi.com/2072-6643/13/9/3052 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 9, p 3052
allfieldsSound	10.3390/nu13093052 doi (DE-627)DOAJ056586973 (DE-599)DOAJa8ed26ddf29a4c978909e531902ee3a6 DE-627 ger DE-627 rakwb eng TX341-641 Neil K. Huang verfasserin aut Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy. serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study Nutrition. Foods and food supply Petra Bůžková verfasserin aut Nirupa R. Matthan verfasserin aut Luc Djoussé verfasserin aut Jorge R. Kizer verfasserin aut Kenneth J. Mukamal verfasserin aut Joseph F. Polak verfasserin aut Alice H. Lichtenstein verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 9, p 3052 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:9, p 3052 https://doi.org/10.3390/nu13093052 kostenfrei https://doaj.org/article/a8ed26ddf29a4c978909e531902ee3a6 kostenfrei https://www.mdpi.com/2072-6643/13/9/3052 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 9, p 3052
language	English
source	In Nutrients 13(2021), 9, p 3052 volume:13 year:2021 number:9, p 3052
sourceStr	In Nutrients 13(2021), 9, p 3052 volume:13 year:2021 number:9, p 3052
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Nutrients
authorswithroles_txt_mv	Neil K. Huang @@aut@@ Petra Bůžková @@aut@@ Nirupa R. Matthan @@aut@@ Luc Djoussé @@aut@@ Jorge R. Kizer @@aut@@ Kenneth J. Mukamal @@aut@@ Joseph F. Polak @@aut@@ Alice H. Lichtenstein @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	610604155
id	DOAJ056586973
language_de	englisch
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Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. 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callnumber-first	T - Technology
author	Neil K. Huang
spellingShingle	Neil K. Huang misc TX341-641 misc serum non-esterified fatty acid misc conjugated linoleic acid misc palmitoleic acid misc carotid intima-media thickness misc flow-mediated dilation misc Cardiovascular Health Study misc Nutrition. Foods and food supply Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS)
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topic_title	TX341-641 Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS) serum non-esterified fatty acid conjugated linoleic acid palmitoleic acid carotid intima-media thickness flow-mediated dilation Cardiovascular Health Study
topic	misc TX341-641 misc serum non-esterified fatty acid misc conjugated linoleic acid misc palmitoleic acid misc carotid intima-media thickness misc flow-mediated dilation misc Cardiovascular Health Study misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc serum non-esterified fatty acid misc conjugated linoleic acid misc palmitoleic acid misc carotid intima-media thickness misc flow-mediated dilation misc Cardiovascular Health Study misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc serum non-esterified fatty acid misc conjugated linoleic acid misc palmitoleic acid misc carotid intima-media thickness misc flow-mediated dilation misc Cardiovascular Health Study misc Nutrition. Foods and food supply
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title	Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS)
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title_full	Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS)
author_sort	Neil K. Huang
journal	Nutrients
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author_browse	Neil K. Huang Petra Bůžková Nirupa R. Matthan Luc Djoussé Jorge R. Kizer Kenneth J. Mukamal Joseph F. Polak Alice H. Lichtenstein
container_volume	13
class	TX341-641
format_se	Elektronische Aufsätze
author-letter	Neil K. Huang
doi_str_mv	10.3390/nu13093052
author2-role	verfasserin
title_sort	serum non-esterified fatty acids, carotid artery intima-media thickness and flow-mediated dilation in older adults: the cardiovascular health study (chs)
callnumber	TX341-641
title_auth	Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS)
abstract	<b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy.
abstractGer	<b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy.
abstract_unstemmed	<b<Backgrounds and aims:</b< Elevated common carotid artery intima-media thickness (carotid IMT) and diminished flow-mediated dilation (FMD) are early subclinical indicators of atherosclerosis. Serum total non-esterified fatty acid (NEFA) concentrations have been positively associated with subclinical atherosclerosis. The relations between individual NEFA, carotid IMT and FMD have as yet to be assessed. <b<Methods:</b< We investigated the associations between fasting serum individual NEFA, carotid IMT and FMD among Cardiovascular Health Study (CHS) participants with (<i<n</i< = 255 for carotid IMT, 301 for FMD) or without (<i<n</i< = 1314 for carotid IMT, 1462 for FMD) known atherosclerotic cardiovascular disease (ASCVD). Using archived samples (fasting) collected from 1996–1997 (baseline), 35 individual NEFAs were measured using gas chromatography. Carotid IMT and estimated plaque thickness (mean of maximum internal carotid IMT) were determined in 1998–1999. FMD was measured in 1997–1998. Linear regression adjusted by the Holm-Bonferroni method was used to assess relations between individual NEFA, carotid IMT and FMD. <b<Results:</b< In multivariable adjusted linear regression models per SD increment, the non-esterified <i<trans</i< fatty acid conjugated linoleic acid (<i<trans</i<-18:2 CLA) was positively associated with carotid IMT [β (95% CI): 44.8 (19.2, 70.4), <i<p</i< = 0.025] among participants with, but not without, ASCVD [2.16 (−6.74, 11.5), <i<p</i< = 1.000]. Non-esterified <i<cis</i<-palmitoleic acid (16:1n-7<i<c</i<) was positively associated with FMD [19.7 (8.34, 31.0), <i<p</i< = 0.024] among participants without, but not with ASCVD. No significant associations between NEFAs and estimated plaque thickness were observed. <b<Conclusions:</b< In older adults, serum non-esterified CLA and palmitoleic acid were positively associated with carotid IMT and FMD, respectively, suggesting potential modifiable biomarkers for arteriopathy.
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Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS)

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