Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)

Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective...
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Autor*in:	Annette M. Krais [verfasserIn] Julie Y. Essig [verfasserIn] Louise Gren [verfasserIn] Carolina Vogs [verfasserIn] Eva Assarsson [verfasserIn] Katrin Dierschke [verfasserIn] Jörn Nielsen [verfasserIn] Bo Strandberg [verfasserIn] Joakim Pagels [verfasserIn] Karin Broberg [verfasserIn] Christian H. Lindh [verfasserIn] Anders Gudmundsson [verfasserIn] Aneta Wierzbicka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 18(2021), 6492, p 6492
Übergeordnetes Werk:	volume:18 ; year:2021 ; number:6492, p 6492

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph18126492

Katalog-ID:	DOAJ056610181

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allfields	10.3390/ijerph18126492 doi (DE-627)DOAJ056610181 (DE-599)DOAJcf39478ccd074a85ac1649c6b1fd1646 DE-627 ger DE-627 rakwb eng Annette M. Krais verfasserin aut Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction. renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation Medicine R Julie Y. Essig verfasserin aut Louise Gren verfasserin aut Carolina Vogs verfasserin aut Eva Assarsson verfasserin aut Katrin Dierschke verfasserin aut Jörn Nielsen verfasserin aut Bo Strandberg verfasserin aut Joakim Pagels verfasserin aut Karin Broberg verfasserin aut Christian H. Lindh verfasserin aut Anders Gudmundsson verfasserin aut Aneta Wierzbicka verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 6492, p 6492 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:6492, p 6492 https://doi.org/10.3390/ijerph18126492 kostenfrei https://doaj.org/article/cf39478ccd074a85ac1649c6b1fd1646 kostenfrei https://www.mdpi.com/1660-4601/18/12/6492 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 6492, p 6492
spelling	10.3390/ijerph18126492 doi (DE-627)DOAJ056610181 (DE-599)DOAJcf39478ccd074a85ac1649c6b1fd1646 DE-627 ger DE-627 rakwb eng Annette M. Krais verfasserin aut Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction. renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation Medicine R Julie Y. Essig verfasserin aut Louise Gren verfasserin aut Carolina Vogs verfasserin aut Eva Assarsson verfasserin aut Katrin Dierschke verfasserin aut Jörn Nielsen verfasserin aut Bo Strandberg verfasserin aut Joakim Pagels verfasserin aut Karin Broberg verfasserin aut Christian H. Lindh verfasserin aut Anders Gudmundsson verfasserin aut Aneta Wierzbicka verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 6492, p 6492 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:6492, p 6492 https://doi.org/10.3390/ijerph18126492 kostenfrei https://doaj.org/article/cf39478ccd074a85ac1649c6b1fd1646 kostenfrei https://www.mdpi.com/1660-4601/18/12/6492 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 6492, p 6492
allfields_unstemmed	10.3390/ijerph18126492 doi (DE-627)DOAJ056610181 (DE-599)DOAJcf39478ccd074a85ac1649c6b1fd1646 DE-627 ger DE-627 rakwb eng Annette M. Krais verfasserin aut Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction. renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation Medicine R Julie Y. Essig verfasserin aut Louise Gren verfasserin aut Carolina Vogs verfasserin aut Eva Assarsson verfasserin aut Katrin Dierschke verfasserin aut Jörn Nielsen verfasserin aut Bo Strandberg verfasserin aut Joakim Pagels verfasserin aut Karin Broberg verfasserin aut Christian H. Lindh verfasserin aut Anders Gudmundsson verfasserin aut Aneta Wierzbicka verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 6492, p 6492 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:6492, p 6492 https://doi.org/10.3390/ijerph18126492 kostenfrei https://doaj.org/article/cf39478ccd074a85ac1649c6b1fd1646 kostenfrei https://www.mdpi.com/1660-4601/18/12/6492 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 6492, p 6492
allfieldsGer	10.3390/ijerph18126492 doi (DE-627)DOAJ056610181 (DE-599)DOAJcf39478ccd074a85ac1649c6b1fd1646 DE-627 ger DE-627 rakwb eng Annette M. Krais verfasserin aut Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction. renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation Medicine R Julie Y. Essig verfasserin aut Louise Gren verfasserin aut Carolina Vogs verfasserin aut Eva Assarsson verfasserin aut Katrin Dierschke verfasserin aut Jörn Nielsen verfasserin aut Bo Strandberg verfasserin aut Joakim Pagels verfasserin aut Karin Broberg verfasserin aut Christian H. Lindh verfasserin aut Anders Gudmundsson verfasserin aut Aneta Wierzbicka verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 6492, p 6492 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:6492, p 6492 https://doi.org/10.3390/ijerph18126492 kostenfrei https://doaj.org/article/cf39478ccd074a85ac1649c6b1fd1646 kostenfrei https://www.mdpi.com/1660-4601/18/12/6492 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 6492, p 6492
allfieldsSound	10.3390/ijerph18126492 doi (DE-627)DOAJ056610181 (DE-599)DOAJcf39478ccd074a85ac1649c6b1fd1646 DE-627 ger DE-627 rakwb eng Annette M. Krais verfasserin aut Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction. renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation Medicine R Julie Y. Essig verfasserin aut Louise Gren verfasserin aut Carolina Vogs verfasserin aut Eva Assarsson verfasserin aut Katrin Dierschke verfasserin aut Jörn Nielsen verfasserin aut Bo Strandberg verfasserin aut Joakim Pagels verfasserin aut Karin Broberg verfasserin aut Christian H. Lindh verfasserin aut Anders Gudmundsson verfasserin aut Aneta Wierzbicka verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 18(2021), 6492, p 6492 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:18 year:2021 number:6492, p 6492 https://doi.org/10.3390/ijerph18126492 kostenfrei https://doaj.org/article/cf39478ccd074a85ac1649c6b1fd1646 kostenfrei https://www.mdpi.com/1660-4601/18/12/6492 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2021 6492, p 6492
language	English
source	In International Journal of Environmental Research and Public Health 18(2021), 6492, p 6492 volume:18 year:2021 number:6492, p 6492
sourceStr	In International Journal of Environmental Research and Public Health 18(2021), 6492, p 6492 volume:18 year:2021 number:6492, p 6492
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation Medicine R
isfreeaccess_bool	true
container_title	International Journal of Environmental Research and Public Health
authorswithroles_txt_mv	Annette M. Krais @@aut@@ Julie Y. Essig @@aut@@ Louise Gren @@aut@@ Carolina Vogs @@aut@@ Eva Assarsson @@aut@@ Katrin Dierschke @@aut@@ Jörn Nielsen @@aut@@ Bo Strandberg @@aut@@ Joakim Pagels @@aut@@ Karin Broberg @@aut@@ Christian H. Lindh @@aut@@ Anders Gudmundsson @@aut@@ Aneta Wierzbicka @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	477992463
id	DOAJ056610181
language_de	englisch
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author	Annette M. Krais
spellingShingle	Annette M. Krais misc renewable diesel misc HVO misc exposure studies misc biomarkers misc aerosol misc lipid peroxidation misc Medicine misc R Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)
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topic_title	Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO) renewable diesel HVO exposure studies biomarkers aerosol lipid peroxidation
topic	misc renewable diesel misc HVO misc exposure studies misc biomarkers misc aerosol misc lipid peroxidation misc Medicine misc R
topic_unstemmed	misc renewable diesel misc HVO misc exposure studies misc biomarkers misc aerosol misc lipid peroxidation misc Medicine misc R
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title	Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)
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title_full	Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)
author_sort	Annette M. Krais
journal	International Journal of Environmental Research and Public Health
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author_browse	Annette M. Krais Julie Y. Essig Louise Gren Carolina Vogs Eva Assarsson Katrin Dierschke Jörn Nielsen Bo Strandberg Joakim Pagels Karin Broberg Christian H. Lindh Anders Gudmundsson Aneta Wierzbicka
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title_sort	biomarkers after controlled inhalation exposure to exhaust from hydrogenated vegetable oil (hvo)
title_auth	Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)
abstract	Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction.
abstractGer	Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction.
abstract_unstemmed	Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM<sub<1</sub< ~1 µg/m<sup<3</sup< and ~90 µg/m<sup<3</sup< for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM<sub<1</sub< ~300 µg/m<sup<3</sup<) increased urinary 4-MHA, a biomarker for <i<p</i<-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, <i<p</i< < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction.
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title_short	Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)
url	https://doi.org/10.3390/ijerph18126492 https://doaj.org/article/cf39478ccd074a85ac1649c6b1fd1646 https://www.mdpi.com/1660-4601/18/12/6492 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601
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author2	Julie Y. Essig Louise Gren Carolina Vogs Eva Assarsson Katrin Dierschke Jörn Nielsen Bo Strandberg Joakim Pagels Karin Broberg Christian H. Lindh Anders Gudmundsson Aneta Wierzbicka
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up_date	2024-07-03T21:52:24.534Z
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