Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Di...
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Autor*in:	João Marcus Oliveira Andrade [verfasserIn] Antônio Sérgio Barcala-Jorge [verfasserIn] Gislaine Cândida Batista-Jorge [verfasserIn] Alanna Fernandes Paraíso [verfasserIn] Kátia Michele de Freitas [verfasserIn] Deborah de Farias Lelis [verfasserIn] André Luiz Sena Guimarães [verfasserIn] Alfredo Maurício Batista de Paula [verfasserIn] Sérgio Henrique Sousa Santos [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol

Übergeordnetes Werk:	In: Biomedicine & Pharmacotherapy - Elsevier, 2021, 112(2019), Seite -
Übergeordnetes Werk:	volume:112 ; year:2019 ; pages:-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.biopha.2019.108634

Katalog-ID:	DOAJ056660685

Internformat


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520			\|a The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1.
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700	0		\|a Antônio Sérgio Barcala-Jorge \|e verfasserin \|4 aut
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700	0		\|a André Luiz Sena Guimarães \|e verfasserin \|4 aut
700	0		\|a Alfredo Maurício Batista de Paula \|e verfasserin \|4 aut
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allfields	10.1016/j.biopha.2019.108634 doi (DE-627)DOAJ056660685 (DE-599)DOAJcdba8f9f651545bf80d90437ea0a45b5 DE-627 ger DE-627 rakwb eng RM1-950 João Marcus Oliveira Andrade verfasserin aut Effect of resveratrol on expression of genes involved thermogenesis in mice and humans 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1. Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol Therapeutics. Pharmacology Antônio Sérgio Barcala-Jorge verfasserin aut Gislaine Cândida Batista-Jorge verfasserin aut Alanna Fernandes Paraíso verfasserin aut Kátia Michele de Freitas verfasserin aut Deborah de Farias Lelis verfasserin aut André Luiz Sena Guimarães verfasserin aut Alfredo Maurício Batista de Paula verfasserin aut Sérgio Henrique Sousa Santos verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 112(2019), Seite - (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:112 year:2019 pages:- https://doi.org/10.1016/j.biopha.2019.108634 kostenfrei https://doaj.org/article/cdba8f9f651545bf80d90437ea0a45b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218355379 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 112 2019 -
spelling	10.1016/j.biopha.2019.108634 doi (DE-627)DOAJ056660685 (DE-599)DOAJcdba8f9f651545bf80d90437ea0a45b5 DE-627 ger DE-627 rakwb eng RM1-950 João Marcus Oliveira Andrade verfasserin aut Effect of resveratrol on expression of genes involved thermogenesis in mice and humans 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1. Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol Therapeutics. Pharmacology Antônio Sérgio Barcala-Jorge verfasserin aut Gislaine Cândida Batista-Jorge verfasserin aut Alanna Fernandes Paraíso verfasserin aut Kátia Michele de Freitas verfasserin aut Deborah de Farias Lelis verfasserin aut André Luiz Sena Guimarães verfasserin aut Alfredo Maurício Batista de Paula verfasserin aut Sérgio Henrique Sousa Santos verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 112(2019), Seite - (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:112 year:2019 pages:- https://doi.org/10.1016/j.biopha.2019.108634 kostenfrei https://doaj.org/article/cdba8f9f651545bf80d90437ea0a45b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218355379 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 112 2019 -
allfields_unstemmed	10.1016/j.biopha.2019.108634 doi (DE-627)DOAJ056660685 (DE-599)DOAJcdba8f9f651545bf80d90437ea0a45b5 DE-627 ger DE-627 rakwb eng RM1-950 João Marcus Oliveira Andrade verfasserin aut Effect of resveratrol on expression of genes involved thermogenesis in mice and humans 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1. Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol Therapeutics. Pharmacology Antônio Sérgio Barcala-Jorge verfasserin aut Gislaine Cândida Batista-Jorge verfasserin aut Alanna Fernandes Paraíso verfasserin aut Kátia Michele de Freitas verfasserin aut Deborah de Farias Lelis verfasserin aut André Luiz Sena Guimarães verfasserin aut Alfredo Maurício Batista de Paula verfasserin aut Sérgio Henrique Sousa Santos verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 112(2019), Seite - (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:112 year:2019 pages:- https://doi.org/10.1016/j.biopha.2019.108634 kostenfrei https://doaj.org/article/cdba8f9f651545bf80d90437ea0a45b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218355379 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 112 2019 -
allfieldsGer	10.1016/j.biopha.2019.108634 doi (DE-627)DOAJ056660685 (DE-599)DOAJcdba8f9f651545bf80d90437ea0a45b5 DE-627 ger DE-627 rakwb eng RM1-950 João Marcus Oliveira Andrade verfasserin aut Effect of resveratrol on expression of genes involved thermogenesis in mice and humans 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1. Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol Therapeutics. Pharmacology Antônio Sérgio Barcala-Jorge verfasserin aut Gislaine Cândida Batista-Jorge verfasserin aut Alanna Fernandes Paraíso verfasserin aut Kátia Michele de Freitas verfasserin aut Deborah de Farias Lelis verfasserin aut André Luiz Sena Guimarães verfasserin aut Alfredo Maurício Batista de Paula verfasserin aut Sérgio Henrique Sousa Santos verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 112(2019), Seite - (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:112 year:2019 pages:- https://doi.org/10.1016/j.biopha.2019.108634 kostenfrei https://doaj.org/article/cdba8f9f651545bf80d90437ea0a45b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218355379 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 112 2019 -
allfieldsSound	10.1016/j.biopha.2019.108634 doi (DE-627)DOAJ056660685 (DE-599)DOAJcdba8f9f651545bf80d90437ea0a45b5 DE-627 ger DE-627 rakwb eng RM1-950 João Marcus Oliveira Andrade verfasserin aut Effect of resveratrol on expression of genes involved thermogenesis in mice and humans 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1. Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol Therapeutics. Pharmacology Antônio Sérgio Barcala-Jorge verfasserin aut Gislaine Cândida Batista-Jorge verfasserin aut Alanna Fernandes Paraíso verfasserin aut Kátia Michele de Freitas verfasserin aut Deborah de Farias Lelis verfasserin aut André Luiz Sena Guimarães verfasserin aut Alfredo Maurício Batista de Paula verfasserin aut Sérgio Henrique Sousa Santos verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 112(2019), Seite - (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:112 year:2019 pages:- https://doi.org/10.1016/j.biopha.2019.108634 kostenfrei https://doaj.org/article/cdba8f9f651545bf80d90437ea0a45b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218355379 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 112 2019 -
language	English
source	In Biomedicine & Pharmacotherapy 112(2019), Seite - volume:112 year:2019 pages:-
sourceStr	In Biomedicine & Pharmacotherapy 112(2019), Seite - volume:112 year:2019 pages:-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Biomedicine & Pharmacotherapy
authorswithroles_txt_mv	João Marcus Oliveira Andrade @@aut@@ Antônio Sérgio Barcala-Jorge @@aut@@ Gislaine Cândida Batista-Jorge @@aut@@ Alanna Fernandes Paraíso @@aut@@ Kátia Michele de Freitas @@aut@@ Deborah de Farias Lelis @@aut@@ André Luiz Sena Guimarães @@aut@@ Alfredo Maurício Batista de Paula @@aut@@ Sérgio Henrique Sousa Santos @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	306717565
id	DOAJ056660685
language_de	englisch
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callnumber-first	R - Medicine
author	João Marcus Oliveira Andrade
spellingShingle	João Marcus Oliveira Andrade misc RM1-950 misc Irisin misc FNDC5 misc Browning misc SIRT1 misc Thermogenesis misc Resveratrol misc Therapeutics. Pharmacology Effect of resveratrol on expression of genes involved thermogenesis in mice and humans
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topic_title	RM1-950 Effect of resveratrol on expression of genes involved thermogenesis in mice and humans Irisin FNDC5 Browning SIRT1 Thermogenesis Resveratrol
topic	misc RM1-950 misc Irisin misc FNDC5 misc Browning misc SIRT1 misc Thermogenesis misc Resveratrol misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Irisin misc FNDC5 misc Browning misc SIRT1 misc Thermogenesis misc Resveratrol misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc Irisin misc FNDC5 misc Browning misc SIRT1 misc Thermogenesis misc Resveratrol misc Therapeutics. Pharmacology
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title	Effect of resveratrol on expression of genes involved thermogenesis in mice and humans
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title_full	Effect of resveratrol on expression of genes involved thermogenesis in mice and humans
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author_browse	João Marcus Oliveira Andrade Antônio Sérgio Barcala-Jorge Gislaine Cândida Batista-Jorge Alanna Fernandes Paraíso Kátia Michele de Freitas Deborah de Farias Lelis André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos
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title_sort	effect of resveratrol on expression of genes involved thermogenesis in mice and humans
callnumber	RM1-950
title_auth	Effect of resveratrol on expression of genes involved thermogenesis in mice and humans
abstract	The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1.
abstractGer	The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1.
abstract_unstemmed	The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in the adipose tissue of mice and humans. Thirty-two male mice were randomly divided into four groups (n = 8) and fed with: Standard Diet; Standard Diet + Resveratrol (400 mg/kg); High-fat Diet; High-fat Diet + Resveratrol for eight weeks. Twenty male and female volunteers, aged 30–55 years, BMI ≥ 30 kg/m² were divided into two groups and treated for four weeks with 500 mg trans-resveratrol or placebo, adipose tissue biopsies were taken. Analysis of body weight, food intake, glycemic and lipid profiles, mRNA expression from tissues and primary culture of adipocytes were performed. The main results show that resveratrol improves the glycaemic and lipid profiles along with an increase in the levels of UCP1, PRDM16, PGC1α, and SIRT1. The increase in FNDC5 expression was observed in the mouse and human subcutaneous adipose tissue. The SIRT1 antagonist in adipocyte primary culture resulted in decreased FNDC5 expression. Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1, PRDM16, PGC1α and that increased FNDC5 expression in the subcutaneous adipose tissue from mice and human might be modulated by SIRT1.
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title_short	Effect of resveratrol on expression of genes involved thermogenesis in mice and humans
url	https://doi.org/10.1016/j.biopha.2019.108634 https://doaj.org/article/cdba8f9f651545bf80d90437ea0a45b5 http://www.sciencedirect.com/science/article/pii/S0753332218355379 https://doaj.org/toc/0753-3322
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Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

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