Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation

Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, i...
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Autor*in:	Winnie Y. Zou [verfasserIn] Sarah E. Blutt [verfasserIn] Xi-Lei Zeng [verfasserIn] Min-Shan Chen [verfasserIn] Yuan-Hung Lo [verfasserIn] David Castillo-Azofeifa [verfasserIn] Ophir D. Klein [verfasserIn] Noah F. Shroyer [verfasserIn] Mark Donowitz [verfasserIn] Mary K. Estes [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	rotavirus RV intestinal stem cell ISC epithelial WNT regeneration

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 22(2018), 4, Seite 1003-1015
Übergeordnetes Werk:	volume:22 ; year:2018 ; number:4 ; pages:1003-1015

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2017.12.093

Katalog-ID:	DOAJ056783949

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520			\|a Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior.
650		4	\|a rotavirus
650		4	\|a RV
650		4	\|a intestinal stem cell
650		4	\|a ISC
650		4	\|a epithelial WNT
650		4	\|a regeneration
653		0	\|a Biology (General)
700	0		\|a Sarah E. Blutt \|e verfasserin \|4 aut
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700	0		\|a Min-Shan Chen \|e verfasserin \|4 aut
700	0		\|a Yuan-Hung Lo \|e verfasserin \|4 aut
700	0		\|a David Castillo-Azofeifa \|e verfasserin \|4 aut
700	0		\|a Ophir D. Klein \|e verfasserin \|4 aut
700	0		\|a Noah F. Shroyer \|e verfasserin \|4 aut
700	0		\|a Mark Donowitz \|e verfasserin \|4 aut
700	0		\|a Mary K. Estes \|e verfasserin \|4 aut
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allfields	10.1016/j.celrep.2017.12.093 doi (DE-627)DOAJ056783949 (DE-599)DOAJ154928b629d4478b80630d5a50486fba DE-627 ger DE-627 rakwb eng QH301-705.5 Winnie Y. Zou verfasserin aut Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior. rotavirus RV intestinal stem cell ISC epithelial WNT regeneration Biology (General) Sarah E. Blutt verfasserin aut Xi-Lei Zeng verfasserin aut Min-Shan Chen verfasserin aut Yuan-Hung Lo verfasserin aut David Castillo-Azofeifa verfasserin aut Ophir D. Klein verfasserin aut Noah F. Shroyer verfasserin aut Mark Donowitz verfasserin aut Mary K. Estes verfasserin aut In Cell Reports Elsevier, 2015 22(2018), 4, Seite 1003-1015 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:22 year:2018 number:4 pages:1003-1015 https://doi.org/10.1016/j.celrep.2017.12.093 kostenfrei https://doaj.org/article/154928b629d4478b80630d5a50486fba kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717319307 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 22 2018 4 1003-1015
spelling	10.1016/j.celrep.2017.12.093 doi (DE-627)DOAJ056783949 (DE-599)DOAJ154928b629d4478b80630d5a50486fba DE-627 ger DE-627 rakwb eng QH301-705.5 Winnie Y. Zou verfasserin aut Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior. rotavirus RV intestinal stem cell ISC epithelial WNT regeneration Biology (General) Sarah E. Blutt verfasserin aut Xi-Lei Zeng verfasserin aut Min-Shan Chen verfasserin aut Yuan-Hung Lo verfasserin aut David Castillo-Azofeifa verfasserin aut Ophir D. Klein verfasserin aut Noah F. Shroyer verfasserin aut Mark Donowitz verfasserin aut Mary K. Estes verfasserin aut In Cell Reports Elsevier, 2015 22(2018), 4, Seite 1003-1015 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:22 year:2018 number:4 pages:1003-1015 https://doi.org/10.1016/j.celrep.2017.12.093 kostenfrei https://doaj.org/article/154928b629d4478b80630d5a50486fba kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717319307 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 22 2018 4 1003-1015
allfields_unstemmed	10.1016/j.celrep.2017.12.093 doi (DE-627)DOAJ056783949 (DE-599)DOAJ154928b629d4478b80630d5a50486fba DE-627 ger DE-627 rakwb eng QH301-705.5 Winnie Y. Zou verfasserin aut Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior. rotavirus RV intestinal stem cell ISC epithelial WNT regeneration Biology (General) Sarah E. Blutt verfasserin aut Xi-Lei Zeng verfasserin aut Min-Shan Chen verfasserin aut Yuan-Hung Lo verfasserin aut David Castillo-Azofeifa verfasserin aut Ophir D. Klein verfasserin aut Noah F. Shroyer verfasserin aut Mark Donowitz verfasserin aut Mary K. Estes verfasserin aut In Cell Reports Elsevier, 2015 22(2018), 4, Seite 1003-1015 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:22 year:2018 number:4 pages:1003-1015 https://doi.org/10.1016/j.celrep.2017.12.093 kostenfrei https://doaj.org/article/154928b629d4478b80630d5a50486fba kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717319307 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 22 2018 4 1003-1015
allfieldsGer	10.1016/j.celrep.2017.12.093 doi (DE-627)DOAJ056783949 (DE-599)DOAJ154928b629d4478b80630d5a50486fba DE-627 ger DE-627 rakwb eng QH301-705.5 Winnie Y. Zou verfasserin aut Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior. rotavirus RV intestinal stem cell ISC epithelial WNT regeneration Biology (General) Sarah E. Blutt verfasserin aut Xi-Lei Zeng verfasserin aut Min-Shan Chen verfasserin aut Yuan-Hung Lo verfasserin aut David Castillo-Azofeifa verfasserin aut Ophir D. Klein verfasserin aut Noah F. Shroyer verfasserin aut Mark Donowitz verfasserin aut Mary K. Estes verfasserin aut In Cell Reports Elsevier, 2015 22(2018), 4, Seite 1003-1015 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:22 year:2018 number:4 pages:1003-1015 https://doi.org/10.1016/j.celrep.2017.12.093 kostenfrei https://doaj.org/article/154928b629d4478b80630d5a50486fba kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717319307 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 22 2018 4 1003-1015
allfieldsSound	10.1016/j.celrep.2017.12.093 doi (DE-627)DOAJ056783949 (DE-599)DOAJ154928b629d4478b80630d5a50486fba DE-627 ger DE-627 rakwb eng QH301-705.5 Winnie Y. Zou verfasserin aut Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior. rotavirus RV intestinal stem cell ISC epithelial WNT regeneration Biology (General) Sarah E. Blutt verfasserin aut Xi-Lei Zeng verfasserin aut Min-Shan Chen verfasserin aut Yuan-Hung Lo verfasserin aut David Castillo-Azofeifa verfasserin aut Ophir D. Klein verfasserin aut Noah F. Shroyer verfasserin aut Mark Donowitz verfasserin aut Mary K. Estes verfasserin aut In Cell Reports Elsevier, 2015 22(2018), 4, Seite 1003-1015 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:22 year:2018 number:4 pages:1003-1015 https://doi.org/10.1016/j.celrep.2017.12.093 kostenfrei https://doaj.org/article/154928b629d4478b80630d5a50486fba kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717319307 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 22 2018 4 1003-1015
language	English
source	In Cell Reports 22(2018), 4, Seite 1003-1015 volume:22 year:2018 number:4 pages:1003-1015
sourceStr	In Cell Reports 22(2018), 4, Seite 1003-1015 volume:22 year:2018 number:4 pages:1003-1015
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	rotavirus RV intestinal stem cell ISC epithelial WNT regeneration Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Winnie Y. Zou @@aut@@ Sarah E. Blutt @@aut@@ Xi-Lei Zeng @@aut@@ Min-Shan Chen @@aut@@ Yuan-Hung Lo @@aut@@ David Castillo-Azofeifa @@aut@@ Ophir D. Klein @@aut@@ Noah F. Shroyer @@aut@@ Mark Donowitz @@aut@@ Mary K. Estes @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ056783949
language_de	englisch
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callnumber-first	Q - Science
author	Winnie Y. Zou
spellingShingle	Winnie Y. Zou misc QH301-705.5 misc rotavirus misc RV misc intestinal stem cell misc ISC misc epithelial WNT misc regeneration misc Biology (General) Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation
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topic_title	QH301-705.5 Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation rotavirus RV intestinal stem cell ISC epithelial WNT regeneration
topic	misc QH301-705.5 misc rotavirus misc RV misc intestinal stem cell misc ISC misc epithelial WNT misc regeneration misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc rotavirus misc RV misc intestinal stem cell misc ISC misc epithelial WNT misc regeneration misc Biology (General)
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title	Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation
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title_full	Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation
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author_browse	Winnie Y. Zou Sarah E. Blutt Xi-Lei Zeng Min-Shan Chen Yuan-Hung Lo David Castillo-Azofeifa Ophir D. Klein Noah F. Shroyer Mark Donowitz Mary K. Estes
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doi_str_mv	10.1016/j.celrep.2017.12.093
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title_sort	epithelial wnt ligands are essential drivers of intestinal stem cell activation
callnumber	QH301-705.5
title_auth	Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation
abstract	Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior.
abstractGer	Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior.
abstract_unstemmed	Intestinal stem cells (ISCs) maintain and repair the intestinal epithelium. While regeneration after ISC-targeted damage is increasingly understood, injury-repair mechanisms that direct regeneration following injuries to differentiated cells remain uncharacterized. The enteric pathogen, rotavirus, infects and damages differentiated cells while sparing all ISC populations, thus allowing the unique examination of the response of intact ISC compartments during injury-repair. Upon rotavirus infection in mice, ISC compartments robustly expand and proliferating cells rapidly migrate. Infection results specifically in stimulation of the active crypt-based columnar ISCs, but not alternative reserve ISC populations, as is observed after ISC-targeted damage. Conditional ablation of epithelial WNT secretion diminishes crypt expansion and ISC activation, demonstrating a previously unknown function of epithelial-secreted WNT during injury-repair. These findings indicate a hierarchical preference of crypt-based columnar cells (CBCs) over other potential ISC populations during epithelial restitution and the importance of epithelial-derived signals in regulating ISC behavior.
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title_short	Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation
url	https://doi.org/10.1016/j.celrep.2017.12.093 https://doaj.org/article/154928b629d4478b80630d5a50486fba http://www.sciencedirect.com/science/article/pii/S2211124717319307 https://doaj.org/toc/2211-1247
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Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation

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