Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization

Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Luis eJacinto [verfasserIn] Joana eReis [verfasserIn] Nuno eDias [verfasserIn] João J Cerqueira [verfasserIn] José Higino Correia [verfasserIn] Nuno eSousa [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Amygdala Anxiety stress Local Field Potentials pre-frontal cortex ventral hippocampus

Übergeordnetes Werk:	In: Frontiers in Behavioral Neuroscience - Frontiers Media S.A., 2008, 7(2013)
Übergeordnetes Werk:	volume:7 ; year:2013

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnbeh.2013.00127

Katalog-ID:	DOAJ056794657

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language	English
source	In Frontiers in Behavioral Neuroscience 7(2013) volume:7 year:2013
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topic_facet	Amygdala Anxiety stress Local Field Potentials pre-frontal cortex ventral hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Behavioral Neuroscience
authorswithroles_txt_mv	Luis eJacinto @@aut@@ Joana eReis @@aut@@ Nuno eDias @@aut@@ João J Cerqueira @@aut@@ José Higino Correia @@aut@@ Nuno eSousa @@aut@@
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callnumber-first	R - Medicine
author	Luis eJacinto
spellingShingle	Luis eJacinto misc RC321-571 misc Amygdala misc Anxiety misc stress misc Local Field Potentials misc pre-frontal cortex misc ventral hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
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topic_title	RC321-571 Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization Amygdala Anxiety stress Local Field Potentials pre-frontal cortex ventral hippocampus
topic	misc RC321-571 misc Amygdala misc Anxiety misc stress misc Local Field Potentials misc pre-frontal cortex misc ventral hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Amygdala misc Anxiety misc stress misc Local Field Potentials misc pre-frontal cortex misc ventral hippocampus misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
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title_full	Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
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title_sort	stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
callnumber	RC321-571
title_auth	Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
abstract	Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.
abstractGer	Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.
abstract_unstemmed	Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.
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title_short	Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
url	https://doi.org/10.3389/fnbeh.2013.00127 https://doaj.org/article/21204b47383341e6bfde8dbe8a9bbde7 http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00127/full https://doaj.org/toc/1662-5153
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author2	Joana eReis Nuno eDias João J Cerqueira José Higino Correia Nuno eSousa
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up_date	2024-07-03T22:53:07.332Z
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Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization

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