Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmun...
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Autor*in:	Angita Jain [verfasserIn] Nadine Norton [verfasserIn] Katelyn A. Bruno [verfasserIn] Leslie T. Cooper [verfasserIn] Paldeep S. Atwal [verfasserIn] DeLisa Fairweather [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	dilated cardiomyopathy familial dilated cardiomyopathy idiopathic dilated cardiomyopathy sex differences sex ratio pathogenesis

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 11, p 2289
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:11, p 2289

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10112289

Katalog-ID:	DOAJ056939973

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520			\|a Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmune diseases, exposure to chemicals/toxins as well as endocrine and neuromuscular causes. DCM is inherited in 20–50% of cases where more than 30 genes have been implicated in the development of DCM with pathogenic variants in <i<TTN</i< (Titin) most frequently associated with disease. Even though male sex is a risk factor for heart failure, few studies have examined sex differences in the pathogenesis of DCM. We searched the literature for studies examining idiopathic or familial/genetic DCM that reported data by sex in order to determine the sex ratio of disease. We found 31 studies that reported data by sex for non-genetic DCM with an average overall sex ratio of 2.5:1 male to female and 7 studies for familial/genetic DCM with an overall average sex ratio of 1.7:1 male to female. No manuscripts that we found had more females than males in their studies. We describe basic and clinical research findings that may explain the increase in DCM in males over females based on sex differences in basic physiology and the immune and fibrotic response to damage caused by mutations, infections, chemotherapy agents and autoimmune responses.
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allfieldsSound	10.3390/jcm10112289 doi (DE-627)DOAJ056939973 (DE-599)DOAJacbb0db6e9984e25948640e810c3afb7 DE-627 ger DE-627 rakwb eng Angita Jain verfasserin aut Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmune diseases, exposure to chemicals/toxins as well as endocrine and neuromuscular causes. DCM is inherited in 20–50% of cases where more than 30 genes have been implicated in the development of DCM with pathogenic variants in <i<TTN</i< (Titin) most frequently associated with disease. Even though male sex is a risk factor for heart failure, few studies have examined sex differences in the pathogenesis of DCM. We searched the literature for studies examining idiopathic or familial/genetic DCM that reported data by sex in order to determine the sex ratio of disease. We found 31 studies that reported data by sex for non-genetic DCM with an average overall sex ratio of 2.5:1 male to female and 7 studies for familial/genetic DCM with an overall average sex ratio of 1.7:1 male to female. No manuscripts that we found had more females than males in their studies. We describe basic and clinical research findings that may explain the increase in DCM in males over females based on sex differences in basic physiology and the immune and fibrotic response to damage caused by mutations, infections, chemotherapy agents and autoimmune responses. dilated cardiomyopathy familial dilated cardiomyopathy idiopathic dilated cardiomyopathy sex differences sex ratio pathogenesis Medicine R Nadine Norton verfasserin aut Katelyn A. Bruno verfasserin aut Leslie T. Cooper verfasserin aut Paldeep S. Atwal verfasserin aut DeLisa Fairweather verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 11, p 2289 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:11, p 2289 https://doi.org/10.3390/jcm10112289 kostenfrei https://doaj.org/article/acbb0db6e9984e25948640e810c3afb7 kostenfrei https://www.mdpi.com/2077-0383/10/11/2289 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11, p 2289
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author	Angita Jain
spellingShingle	Angita Jain misc dilated cardiomyopathy misc familial dilated cardiomyopathy misc idiopathic dilated cardiomyopathy misc sex differences misc sex ratio misc pathogenesis misc Medicine misc R Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy
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topic_title	Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy dilated cardiomyopathy familial dilated cardiomyopathy idiopathic dilated cardiomyopathy sex differences sex ratio pathogenesis
topic	misc dilated cardiomyopathy misc familial dilated cardiomyopathy misc idiopathic dilated cardiomyopathy misc sex differences misc sex ratio misc pathogenesis misc Medicine misc R
topic_unstemmed	misc dilated cardiomyopathy misc familial dilated cardiomyopathy misc idiopathic dilated cardiomyopathy misc sex differences misc sex ratio misc pathogenesis misc Medicine misc R
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title	Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy
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title_full	Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy
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title_sort	sex differences, genetic and environmental influences on dilated cardiomyopathy
title_auth	Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy
abstract	Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmune diseases, exposure to chemicals/toxins as well as endocrine and neuromuscular causes. DCM is inherited in 20–50% of cases where more than 30 genes have been implicated in the development of DCM with pathogenic variants in <i<TTN</i< (Titin) most frequently associated with disease. Even though male sex is a risk factor for heart failure, few studies have examined sex differences in the pathogenesis of DCM. We searched the literature for studies examining idiopathic or familial/genetic DCM that reported data by sex in order to determine the sex ratio of disease. We found 31 studies that reported data by sex for non-genetic DCM with an average overall sex ratio of 2.5:1 male to female and 7 studies for familial/genetic DCM with an overall average sex ratio of 1.7:1 male to female. No manuscripts that we found had more females than males in their studies. We describe basic and clinical research findings that may explain the increase in DCM in males over females based on sex differences in basic physiology and the immune and fibrotic response to damage caused by mutations, infections, chemotherapy agents and autoimmune responses.
abstractGer	Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmune diseases, exposure to chemicals/toxins as well as endocrine and neuromuscular causes. DCM is inherited in 20–50% of cases where more than 30 genes have been implicated in the development of DCM with pathogenic variants in <i<TTN</i< (Titin) most frequently associated with disease. Even though male sex is a risk factor for heart failure, few studies have examined sex differences in the pathogenesis of DCM. We searched the literature for studies examining idiopathic or familial/genetic DCM that reported data by sex in order to determine the sex ratio of disease. We found 31 studies that reported data by sex for non-genetic DCM with an average overall sex ratio of 2.5:1 male to female and 7 studies for familial/genetic DCM with an overall average sex ratio of 1.7:1 male to female. No manuscripts that we found had more females than males in their studies. We describe basic and clinical research findings that may explain the increase in DCM in males over females based on sex differences in basic physiology and the immune and fibrotic response to damage caused by mutations, infections, chemotherapy agents and autoimmune responses.
abstract_unstemmed	Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle and impaired systolic function and is the second most common cause of heart failure after coronary heart disease. The etiology of DCM is diverse including genetic pathogenic variants, infection, inflammation, autoimmune diseases, exposure to chemicals/toxins as well as endocrine and neuromuscular causes. DCM is inherited in 20–50% of cases where more than 30 genes have been implicated in the development of DCM with pathogenic variants in <i<TTN</i< (Titin) most frequently associated with disease. Even though male sex is a risk factor for heart failure, few studies have examined sex differences in the pathogenesis of DCM. We searched the literature for studies examining idiopathic or familial/genetic DCM that reported data by sex in order to determine the sex ratio of disease. We found 31 studies that reported data by sex for non-genetic DCM with an average overall sex ratio of 2.5:1 male to female and 7 studies for familial/genetic DCM with an overall average sex ratio of 1.7:1 male to female. No manuscripts that we found had more females than males in their studies. We describe basic and clinical research findings that may explain the increase in DCM in males over females based on sex differences in basic physiology and the immune and fibrotic response to damage caused by mutations, infections, chemotherapy agents and autoimmune responses.
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title_short	Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy
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