Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer

Anti-angiogenic approaches targeting the vascular endothelial growth factor (VEGF) signaling pathway have been a significant research focus during the past decades and are well established in clinical practice. Despite the expectations, their benefit is ephemeral in several diseases, including speci...
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Autor*in:	Fatema Tuz Zahra [verfasserIn] Md. Sanaullah Sajib [verfasserIn] Constantinos M. Mikelis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	bFGF VEGF angiogenesis anti-angiogenic therapy resistance cancer

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 6, p 1422
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:6, p 1422

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13061422

Katalog-ID:	DOAJ057010943

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allfieldsSound	10.3390/cancers13061422 doi (DE-627)DOAJ057010943 (DE-599)DOAJ7e562974930f463cb8f31d8a051a4c90 DE-627 ger DE-627 rakwb eng RC254-282 Fatema Tuz Zahra verfasserin aut Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anti-angiogenic approaches targeting the vascular endothelial growth factor (VEGF) signaling pathway have been a significant research focus during the past decades and are well established in clinical practice. Despite the expectations, their benefit is ephemeral in several diseases, including specific cancers. One of the most prominent side effects of the current, VEGF-based, anti-angiogenic treatments remains the development of resistance, mostly due to the upregulation and compensatory mechanisms of other growth factors, with the basic fibroblast growth factor (bFGF) being at the top of the list. Over the past decade, several anti-angiogenic approaches targeting simultaneously different growth factors and their signaling pathways have been developed and some have reached the clinical practice. In the present review, we summarize the knowledge regarding resistance mechanisms upon anti-angiogenic treatment, mainly focusing on bFGF. We discuss its role in acquired resistance upon prolonged anti-angiogenic treatment in different tumor settings, outline the reported resistance mechanisms leading to bFGF upregulation, and summarize the efforts and outcome of combined anti-angiogenic approaches to date. bFGF VEGF angiogenesis anti-angiogenic therapy resistance cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Md. Sanaullah Sajib verfasserin aut Constantinos M. Mikelis verfasserin aut In Cancers MDPI AG, 2010 13(2021), 6, p 1422 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:6, p 1422 https://doi.org/10.3390/cancers13061422 kostenfrei https://doaj.org/article/7e562974930f463cb8f31d8a051a4c90 kostenfrei https://www.mdpi.com/2072-6694/13/6/1422 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 6, p 1422
language	English
source	In Cancers 13(2021), 6, p 1422 volume:13 year:2021 number:6, p 1422
sourceStr	In Cancers 13(2021), 6, p 1422 volume:13 year:2021 number:6, p 1422
format_phy_str_mv	Article
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topic_facet	bFGF VEGF angiogenesis anti-angiogenic therapy resistance cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Fatema Tuz Zahra @@aut@@ Md. Sanaullah Sajib @@aut@@ Constantinos M. Mikelis @@aut@@
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callnumber-first	R - Medicine
author	Fatema Tuz Zahra
spellingShingle	Fatema Tuz Zahra misc RC254-282 misc bFGF misc VEGF misc angiogenesis misc anti-angiogenic therapy misc resistance misc cancer misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer
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topic_title	RC254-282 Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer bFGF VEGF angiogenesis anti-angiogenic therapy resistance cancer
topic	misc RC254-282 misc bFGF misc VEGF misc angiogenesis misc anti-angiogenic therapy misc resistance misc cancer misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc bFGF misc VEGF misc angiogenesis misc anti-angiogenic therapy misc resistance misc cancer misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer
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title_full	Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer
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title_auth	Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer
abstract	Anti-angiogenic approaches targeting the vascular endothelial growth factor (VEGF) signaling pathway have been a significant research focus during the past decades and are well established in clinical practice. Despite the expectations, their benefit is ephemeral in several diseases, including specific cancers. One of the most prominent side effects of the current, VEGF-based, anti-angiogenic treatments remains the development of resistance, mostly due to the upregulation and compensatory mechanisms of other growth factors, with the basic fibroblast growth factor (bFGF) being at the top of the list. Over the past decade, several anti-angiogenic approaches targeting simultaneously different growth factors and their signaling pathways have been developed and some have reached the clinical practice. In the present review, we summarize the knowledge regarding resistance mechanisms upon anti-angiogenic treatment, mainly focusing on bFGF. We discuss its role in acquired resistance upon prolonged anti-angiogenic treatment in different tumor settings, outline the reported resistance mechanisms leading to bFGF upregulation, and summarize the efforts and outcome of combined anti-angiogenic approaches to date.
abstractGer	Anti-angiogenic approaches targeting the vascular endothelial growth factor (VEGF) signaling pathway have been a significant research focus during the past decades and are well established in clinical practice. Despite the expectations, their benefit is ephemeral in several diseases, including specific cancers. One of the most prominent side effects of the current, VEGF-based, anti-angiogenic treatments remains the development of resistance, mostly due to the upregulation and compensatory mechanisms of other growth factors, with the basic fibroblast growth factor (bFGF) being at the top of the list. Over the past decade, several anti-angiogenic approaches targeting simultaneously different growth factors and their signaling pathways have been developed and some have reached the clinical practice. In the present review, we summarize the knowledge regarding resistance mechanisms upon anti-angiogenic treatment, mainly focusing on bFGF. We discuss its role in acquired resistance upon prolonged anti-angiogenic treatment in different tumor settings, outline the reported resistance mechanisms leading to bFGF upregulation, and summarize the efforts and outcome of combined anti-angiogenic approaches to date.
abstract_unstemmed	Anti-angiogenic approaches targeting the vascular endothelial growth factor (VEGF) signaling pathway have been a significant research focus during the past decades and are well established in clinical practice. Despite the expectations, their benefit is ephemeral in several diseases, including specific cancers. One of the most prominent side effects of the current, VEGF-based, anti-angiogenic treatments remains the development of resistance, mostly due to the upregulation and compensatory mechanisms of other growth factors, with the basic fibroblast growth factor (bFGF) being at the top of the list. Over the past decade, several anti-angiogenic approaches targeting simultaneously different growth factors and their signaling pathways have been developed and some have reached the clinical practice. In the present review, we summarize the knowledge regarding resistance mechanisms upon anti-angiogenic treatment, mainly focusing on bFGF. We discuss its role in acquired resistance upon prolonged anti-angiogenic treatment in different tumor settings, outline the reported resistance mechanisms leading to bFGF upregulation, and summarize the efforts and outcome of combined anti-angiogenic approaches to date.
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