Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy

In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for G...
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Autor*in:	Andrea Palombieri [verfasserIn] Serena Robetto [verfasserIn] Federica Di Profio [verfasserIn] Vittorio Sarchese [verfasserIn] Paola Fruci [verfasserIn] Maria Cristina Bona [verfasserIn] Giuseppe Ru [verfasserIn] Riccardo Orusa [verfasserIn] Fulvio Marsilio [verfasserIn] Vito Martella [verfasserIn] Barbara Di Martino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA

Übergeordnetes Werk:	In: Animals - MDPI AG, 2011, 10(2020), 12, p 2351
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:12, p 2351

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ani10122351

Katalog-ID:	DOAJ05706122X

Internformat


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author_variant	a p ap s r sr f d p fdp v s vs p f pf m c b mcb g r gr r o ro f m fm v m vm b d m bdm
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publishDate	2020
allfields	10.3390/ani10122351 doi (DE-627)DOAJ05706122X (DE-599)DOAJ2cabe55739a24be7ac2b2eb4d5dae163 DE-627 ger DE-627 rakwb eng SF600-1100 QL1-991 Andrea Palombieri verfasserin aut Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected. hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA Veterinary medicine Zoology Serena Robetto verfasserin aut Federica Di Profio verfasserin aut Vittorio Sarchese verfasserin aut Paola Fruci verfasserin aut Maria Cristina Bona verfasserin aut Giuseppe Ru verfasserin aut Riccardo Orusa verfasserin aut Fulvio Marsilio verfasserin aut Vito Martella verfasserin aut Barbara Di Martino verfasserin aut In Animals MDPI AG, 2011 10(2020), 12, p 2351 (DE-627)657589306 (DE-600)2606558-7 20762615 nnns volume:10 year:2020 number:12, p 2351 https://doi.org/10.3390/ani10122351 kostenfrei https://doaj.org/article/2cabe55739a24be7ac2b2eb4d5dae163 kostenfrei https://www.mdpi.com/2076-2615/10/12/2351 kostenfrei https://doaj.org/toc/2076-2615 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2351
spelling	10.3390/ani10122351 doi (DE-627)DOAJ05706122X (DE-599)DOAJ2cabe55739a24be7ac2b2eb4d5dae163 DE-627 ger DE-627 rakwb eng SF600-1100 QL1-991 Andrea Palombieri verfasserin aut Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected. hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA Veterinary medicine Zoology Serena Robetto verfasserin aut Federica Di Profio verfasserin aut Vittorio Sarchese verfasserin aut Paola Fruci verfasserin aut Maria Cristina Bona verfasserin aut Giuseppe Ru verfasserin aut Riccardo Orusa verfasserin aut Fulvio Marsilio verfasserin aut Vito Martella verfasserin aut Barbara Di Martino verfasserin aut In Animals MDPI AG, 2011 10(2020), 12, p 2351 (DE-627)657589306 (DE-600)2606558-7 20762615 nnns volume:10 year:2020 number:12, p 2351 https://doi.org/10.3390/ani10122351 kostenfrei https://doaj.org/article/2cabe55739a24be7ac2b2eb4d5dae163 kostenfrei https://www.mdpi.com/2076-2615/10/12/2351 kostenfrei https://doaj.org/toc/2076-2615 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2351
allfields_unstemmed	10.3390/ani10122351 doi (DE-627)DOAJ05706122X (DE-599)DOAJ2cabe55739a24be7ac2b2eb4d5dae163 DE-627 ger DE-627 rakwb eng SF600-1100 QL1-991 Andrea Palombieri verfasserin aut Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected. hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA Veterinary medicine Zoology Serena Robetto verfasserin aut Federica Di Profio verfasserin aut Vittorio Sarchese verfasserin aut Paola Fruci verfasserin aut Maria Cristina Bona verfasserin aut Giuseppe Ru verfasserin aut Riccardo Orusa verfasserin aut Fulvio Marsilio verfasserin aut Vito Martella verfasserin aut Barbara Di Martino verfasserin aut In Animals MDPI AG, 2011 10(2020), 12, p 2351 (DE-627)657589306 (DE-600)2606558-7 20762615 nnns volume:10 year:2020 number:12, p 2351 https://doi.org/10.3390/ani10122351 kostenfrei https://doaj.org/article/2cabe55739a24be7ac2b2eb4d5dae163 kostenfrei https://www.mdpi.com/2076-2615/10/12/2351 kostenfrei https://doaj.org/toc/2076-2615 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2351
allfieldsGer	10.3390/ani10122351 doi (DE-627)DOAJ05706122X (DE-599)DOAJ2cabe55739a24be7ac2b2eb4d5dae163 DE-627 ger DE-627 rakwb eng SF600-1100 QL1-991 Andrea Palombieri verfasserin aut Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected. hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA Veterinary medicine Zoology Serena Robetto verfasserin aut Federica Di Profio verfasserin aut Vittorio Sarchese verfasserin aut Paola Fruci verfasserin aut Maria Cristina Bona verfasserin aut Giuseppe Ru verfasserin aut Riccardo Orusa verfasserin aut Fulvio Marsilio verfasserin aut Vito Martella verfasserin aut Barbara Di Martino verfasserin aut In Animals MDPI AG, 2011 10(2020), 12, p 2351 (DE-627)657589306 (DE-600)2606558-7 20762615 nnns volume:10 year:2020 number:12, p 2351 https://doi.org/10.3390/ani10122351 kostenfrei https://doaj.org/article/2cabe55739a24be7ac2b2eb4d5dae163 kostenfrei https://www.mdpi.com/2076-2615/10/12/2351 kostenfrei https://doaj.org/toc/2076-2615 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2351
allfieldsSound	10.3390/ani10122351 doi (DE-627)DOAJ05706122X (DE-599)DOAJ2cabe55739a24be7ac2b2eb4d5dae163 DE-627 ger DE-627 rakwb eng SF600-1100 QL1-991 Andrea Palombieri verfasserin aut Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected. hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA Veterinary medicine Zoology Serena Robetto verfasserin aut Federica Di Profio verfasserin aut Vittorio Sarchese verfasserin aut Paola Fruci verfasserin aut Maria Cristina Bona verfasserin aut Giuseppe Ru verfasserin aut Riccardo Orusa verfasserin aut Fulvio Marsilio verfasserin aut Vito Martella verfasserin aut Barbara Di Martino verfasserin aut In Animals MDPI AG, 2011 10(2020), 12, p 2351 (DE-627)657589306 (DE-600)2606558-7 20762615 nnns volume:10 year:2020 number:12, p 2351 https://doi.org/10.3390/ani10122351 kostenfrei https://doaj.org/article/2cabe55739a24be7ac2b2eb4d5dae163 kostenfrei https://www.mdpi.com/2076-2615/10/12/2351 kostenfrei https://doaj.org/toc/2076-2615 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2351
language	English
source	In Animals 10(2020), 12, p 2351 volume:10 year:2020 number:12, p 2351
sourceStr	In Animals 10(2020), 12, p 2351 volume:10 year:2020 number:12, p 2351
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA Veterinary medicine Zoology
isfreeaccess_bool	true
container_title	Animals
authorswithroles_txt_mv	Andrea Palombieri @@aut@@ Serena Robetto @@aut@@ Federica Di Profio @@aut@@ Vittorio Sarchese @@aut@@ Paola Fruci @@aut@@ Maria Cristina Bona @@aut@@ Giuseppe Ru @@aut@@ Riccardo Orusa @@aut@@ Fulvio Marsilio @@aut@@ Vito Martella @@aut@@ Barbara Di Martino @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	657589306
id	DOAJ05706122X
language_de	englisch
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callnumber-first	S - Agriculture
author	Andrea Palombieri
spellingShingle	Andrea Palombieri misc SF600-1100 misc QL1-991 misc hepatitis E virus (HEV) misc domestic and wild ruminants misc HEV antibodies misc viral RNA misc Veterinary medicine misc Zoology Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy
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topic_title	SF600-1100 QL1-991 Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy hepatitis E virus (HEV) domestic and wild ruminants HEV antibodies viral RNA
topic	misc SF600-1100 misc QL1-991 misc hepatitis E virus (HEV) misc domestic and wild ruminants misc HEV antibodies misc viral RNA misc Veterinary medicine misc Zoology
topic_unstemmed	misc SF600-1100 misc QL1-991 misc hepatitis E virus (HEV) misc domestic and wild ruminants misc HEV antibodies misc viral RNA misc Veterinary medicine misc Zoology
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title	Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy
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title_full	Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy
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title_sort	surveillance study of hepatitis e virus (hev) in domestic and wild ruminants in northwestern italy
callnumber	SF600-1100
title_auth	Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy
abstract	In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected.
abstractGer	In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected.
abstract_unstemmed	In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected.
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container_issue	12, p 2351
title_short	Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy
url	https://doi.org/10.3390/ani10122351 https://doaj.org/article/2cabe55739a24be7ac2b2eb4d5dae163 https://www.mdpi.com/2076-2615/10/12/2351 https://doaj.org/toc/2076-2615
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Surveillance Study of Hepatitis E Virus (HEV) in Domestic and Wild Ruminants in Northwestern Italy

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