Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures

No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in p...
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Autor*in:	M. Simó [verfasserIn] A. Gurtubay-Antolin [verfasserIn] L. Vaquero [verfasserIn] J. Bruna [verfasserIn] A. Rodríguez-Fornells [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: NeuroImage: Clinical - Elsevier, 2015, 18(2018), Seite 86-96
Übergeordnetes Werk:	volume:18 ; year:2018 ; pages:86-96

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nicl.2017.12.032

Katalog-ID:	DOAJ057088616

Internformat


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520			\|a No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain
653		0	\|a Computer applications to medicine. Medical informatics
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publishDate	2018
allfields	10.1016/j.nicl.2017.12.032 doi (DE-627)DOAJ057088616 (DE-599)DOAJ74c2335139084ae8a5237b9a85219c62 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 M. Simó verfasserin aut Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system A. Gurtubay-Antolin verfasserin aut L. Vaquero verfasserin aut J. Bruna verfasserin aut A. Rodríguez-Fornells verfasserin aut In NeuroImage: Clinical Elsevier, 2015 18(2018), Seite 86-96 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:18 year:2018 pages:86-96 https://doi.org/10.1016/j.nicl.2017.12.032 kostenfrei https://doaj.org/article/74c2335139084ae8a5237b9a85219c62 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217303376 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2018 86-96
spelling	10.1016/j.nicl.2017.12.032 doi (DE-627)DOAJ057088616 (DE-599)DOAJ74c2335139084ae8a5237b9a85219c62 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 M. Simó verfasserin aut Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system A. Gurtubay-Antolin verfasserin aut L. Vaquero verfasserin aut J. Bruna verfasserin aut A. Rodríguez-Fornells verfasserin aut In NeuroImage: Clinical Elsevier, 2015 18(2018), Seite 86-96 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:18 year:2018 pages:86-96 https://doi.org/10.1016/j.nicl.2017.12.032 kostenfrei https://doaj.org/article/74c2335139084ae8a5237b9a85219c62 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217303376 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2018 86-96
allfields_unstemmed	10.1016/j.nicl.2017.12.032 doi (DE-627)DOAJ057088616 (DE-599)DOAJ74c2335139084ae8a5237b9a85219c62 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 M. Simó verfasserin aut Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system A. Gurtubay-Antolin verfasserin aut L. Vaquero verfasserin aut J. Bruna verfasserin aut A. Rodríguez-Fornells verfasserin aut In NeuroImage: Clinical Elsevier, 2015 18(2018), Seite 86-96 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:18 year:2018 pages:86-96 https://doi.org/10.1016/j.nicl.2017.12.032 kostenfrei https://doaj.org/article/74c2335139084ae8a5237b9a85219c62 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217303376 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2018 86-96
allfieldsGer	10.1016/j.nicl.2017.12.032 doi (DE-627)DOAJ057088616 (DE-599)DOAJ74c2335139084ae8a5237b9a85219c62 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 M. Simó verfasserin aut Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system A. Gurtubay-Antolin verfasserin aut L. Vaquero verfasserin aut J. Bruna verfasserin aut A. Rodríguez-Fornells verfasserin aut In NeuroImage: Clinical Elsevier, 2015 18(2018), Seite 86-96 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:18 year:2018 pages:86-96 https://doi.org/10.1016/j.nicl.2017.12.032 kostenfrei https://doaj.org/article/74c2335139084ae8a5237b9a85219c62 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217303376 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2018 86-96
allfieldsSound	10.1016/j.nicl.2017.12.032 doi (DE-627)DOAJ057088616 (DE-599)DOAJ74c2335139084ae8a5237b9a85219c62 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 M. Simó verfasserin aut Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system A. Gurtubay-Antolin verfasserin aut L. Vaquero verfasserin aut J. Bruna verfasserin aut A. Rodríguez-Fornells verfasserin aut In NeuroImage: Clinical Elsevier, 2015 18(2018), Seite 86-96 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:18 year:2018 pages:86-96 https://doi.org/10.1016/j.nicl.2017.12.032 kostenfrei https://doaj.org/article/74c2335139084ae8a5237b9a85219c62 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213158217303376 kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2018 86-96
language	English
source	In NeuroImage: Clinical 18(2018), Seite 86-96 volume:18 year:2018 pages:86-96
sourceStr	In NeuroImage: Clinical 18(2018), Seite 86-96 volume:18 year:2018 pages:86-96
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	NeuroImage: Clinical
authorswithroles_txt_mv	M. Simó @@aut@@ A. Gurtubay-Antolin @@aut@@ L. Vaquero @@aut@@ J. Bruna @@aut@@ A. Rodríguez-Fornells @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	735358869
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language_de	englisch
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topic_title	R858-859.7 RC346-429 Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
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title	Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
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title_full	Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
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author_browse	M. Simó A. Gurtubay-Antolin L. Vaquero J. Bruna A. Rodríguez-Fornells
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title_sort	performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
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title_auth	Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
abstract	No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain
abstractGer	No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain
abstract_unstemmed	No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C−) prior to chemotherapy and a healthy control group (HC).Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C−) and eighteen HC.Between 20 and 30% of patients in both lung cancer groups (C+ and C−) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC.Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population. Keywords: Event-related potentials-ERP, Error-related negativity (ERN), Performance monitoring, Lung cancer, Cognitive impairment, Chemobrain
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title_short	Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
url	https://doi.org/10.1016/j.nicl.2017.12.032 https://doaj.org/article/74c2335139084ae8a5237b9a85219c62 http://www.sciencedirect.com/science/article/pii/S2213158217303376 https://doaj.org/toc/2213-1582
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Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures

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