Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s

We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mecha...
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Gespeichert in:

Autor*in:	Arnis Kuksis [verfasserIn] Waldemar Pruzanski [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	secretory phospholipase A2 phosphatidylcholine sphingomyelin phase diagrams liquid chromatography-mass spectrometry

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 49(2008), 10, Seite 2161-2168
Übergeordnetes Werk:	volume:49 ; year:2008 ; number:10 ; pages:2161-2168

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M800167-JLR200

Katalog-ID:	DOAJ057159033

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520			\|a We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked.
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allfields	10.1194/jlr.M800167-JLR200 doi (DE-627)DOAJ057159033 (DE-599)DOAJ431e0f9de11a4c01ac2135d5a18c2e40 DE-627 ger DE-627 rakwb eng QD415-436 Arnis Kuksis verfasserin aut Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked. secretory phospholipase A2 phosphatidylcholine sphingomyelin phase diagrams liquid chromatography-mass spectrometry Biochemistry Waldemar Pruzanski verfasserin aut In Journal of Lipid Research Elsevier, 2021 49(2008), 10, Seite 2161-2168 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:49 year:2008 number:10 pages:2161-2168 https://doi.org/10.1194/jlr.M800167-JLR200 kostenfrei https://doaj.org/article/431e0f9de11a4c01ac2135d5a18c2e40 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520346393 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2008 10 2161-2168
spelling	10.1194/jlr.M800167-JLR200 doi (DE-627)DOAJ057159033 (DE-599)DOAJ431e0f9de11a4c01ac2135d5a18c2e40 DE-627 ger DE-627 rakwb eng QD415-436 Arnis Kuksis verfasserin aut Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked. secretory phospholipase A2 phosphatidylcholine sphingomyelin phase diagrams liquid chromatography-mass spectrometry Biochemistry Waldemar Pruzanski verfasserin aut In Journal of Lipid Research Elsevier, 2021 49(2008), 10, Seite 2161-2168 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:49 year:2008 number:10 pages:2161-2168 https://doi.org/10.1194/jlr.M800167-JLR200 kostenfrei https://doaj.org/article/431e0f9de11a4c01ac2135d5a18c2e40 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520346393 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2008 10 2161-2168
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allfieldsGer	10.1194/jlr.M800167-JLR200 doi (DE-627)DOAJ057159033 (DE-599)DOAJ431e0f9de11a4c01ac2135d5a18c2e40 DE-627 ger DE-627 rakwb eng QD415-436 Arnis Kuksis verfasserin aut Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked. secretory phospholipase A2 phosphatidylcholine sphingomyelin phase diagrams liquid chromatography-mass spectrometry Biochemistry Waldemar Pruzanski verfasserin aut In Journal of Lipid Research Elsevier, 2021 49(2008), 10, Seite 2161-2168 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:49 year:2008 number:10 pages:2161-2168 https://doi.org/10.1194/jlr.M800167-JLR200 kostenfrei https://doaj.org/article/431e0f9de11a4c01ac2135d5a18c2e40 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520346393 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2008 10 2161-2168
allfieldsSound	10.1194/jlr.M800167-JLR200 doi (DE-627)DOAJ057159033 (DE-599)DOAJ431e0f9de11a4c01ac2135d5a18c2e40 DE-627 ger DE-627 rakwb eng QD415-436 Arnis Kuksis verfasserin aut Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked. secretory phospholipase A2 phosphatidylcholine sphingomyelin phase diagrams liquid chromatography-mass spectrometry Biochemistry Waldemar Pruzanski verfasserin aut In Journal of Lipid Research Elsevier, 2021 49(2008), 10, Seite 2161-2168 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:49 year:2008 number:10 pages:2161-2168 https://doi.org/10.1194/jlr.M800167-JLR200 kostenfrei https://doaj.org/article/431e0f9de11a4c01ac2135d5a18c2e40 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520346393 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 49 2008 10 2161-2168
language	English
source	In Journal of Lipid Research 49(2008), 10, Seite 2161-2168 volume:49 year:2008 number:10 pages:2161-2168
sourceStr	In Journal of Lipid Research 49(2008), 10, Seite 2161-2168 volume:49 year:2008 number:10 pages:2161-2168
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topic_facet	secretory phospholipase A2 phosphatidylcholine sphingomyelin phase diagrams liquid chromatography-mass spectrometry Biochemistry
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container_title	Journal of Lipid Research
authorswithroles_txt_mv	Arnis Kuksis @@aut@@ Waldemar Pruzanski @@aut@@
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callnumber-first	Q - Science
author	Arnis Kuksis
spellingShingle	Arnis Kuksis misc QD415-436 misc secretory phospholipase A2 misc phosphatidylcholine misc sphingomyelin misc phase diagrams misc liquid chromatography-mass spectrometry misc Biochemistry Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s
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topic_title	QD415-436 Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s secretory phospholipase A2 phosphatidylcholine sphingomyelin phase diagrams liquid chromatography-mass spectrometry
topic	misc QD415-436 misc secretory phospholipase A2 misc phosphatidylcholine misc sphingomyelin misc phase diagrams misc liquid chromatography-mass spectrometry misc Biochemistry
topic_unstemmed	misc QD415-436 misc secretory phospholipase A2 misc phosphatidylcholine misc sphingomyelin misc phase diagrams misc liquid chromatography-mass spectrometry misc Biochemistry
topic_browse	misc QD415-436 misc secretory phospholipase A2 misc phosphatidylcholine misc sphingomyelin misc phase diagrams misc liquid chromatography-mass spectrometry misc Biochemistry
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title	Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s
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title_full	Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s
author_sort	Arnis Kuksis
journal	Journal of Lipid Research
journalStr	Journal of Lipid Research
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author_browse	Arnis Kuksis Waldemar Pruzanski
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author-letter	Arnis Kuksis
doi_str_mv	10.1194/jlr.M800167-JLR200
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title_sort	phase composition of lipoprotein sm/cholesterol/ptdcho affects fa specificity of spla2s
callnumber	QD415-436
title_auth	Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s
abstract	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked.
abstractGer	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked.
abstract_unstemmed	We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s
url	https://doi.org/10.1194/jlr.M800167-JLR200 https://doaj.org/article/431e0f9de11a4c01ac2135d5a18c2e40 http://www.sciencedirect.com/science/article/pii/S0022227520346393 https://doaj.org/toc/0022-2275
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doi_str	10.1194/jlr.M800167-JLR200
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up_date	2024-07-04T00:33:32.665Z
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