Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster

The fetus has a high requirement for cholesterol and synthesizes cholesterol at elevated rates. Recent studies suggest that fetal cholesterol also can be obtained from exogenous sources. The purpose of the current study was to examine the transport of maternal cholesterol to the fetus and determine...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Katie T. Burke [verfasserIn] Perry L. Colvin [verfasserIn] Leslie Myatt [verfasserIn] Gregory A. Graf [verfasserIn] Friedhelm Schroeder [verfasserIn] Laura A. Woollett [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	placenta yolk sac Smith-Lemli-Opitz Syndrome low density lipoprotein high density lipoprotein liver X receptor

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 50(2009), 6, Seite 1146-1155
Übergeordnetes Werk:	volume:50 ; year:2009 ; number:6 ; pages:1146-1155

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M800538-JLR200

Katalog-ID:	DOAJ057174784

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topic_facet	placenta yolk sac Smith-Lemli-Opitz Syndrome low density lipoprotein high density lipoprotein liver X receptor Biochemistry
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authorswithroles_txt_mv	Katie T. Burke @@aut@@ Perry L. Colvin @@aut@@ Leslie Myatt @@aut@@ Gregory A. Graf @@aut@@ Friedhelm Schroeder @@aut@@ Laura A. Woollett @@aut@@
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callnumber-first	Q - Science
author	Katie T. Burke
spellingShingle	Katie T. Burke misc QD415-436 misc placenta misc yolk sac misc Smith-Lemli-Opitz Syndrome misc low density lipoprotein misc high density lipoprotein misc liver X receptor misc Biochemistry Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster
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topic_title	QD415-436 Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster placenta yolk sac Smith-Lemli-Opitz Syndrome low density lipoprotein high density lipoprotein liver X receptor
topic	misc QD415-436 misc placenta misc yolk sac misc Smith-Lemli-Opitz Syndrome misc low density lipoprotein misc high density lipoprotein misc liver X receptor misc Biochemistry
topic_unstemmed	misc QD415-436 misc placenta misc yolk sac misc Smith-Lemli-Opitz Syndrome misc low density lipoprotein misc high density lipoprotein misc liver X receptor misc Biochemistry
topic_browse	misc QD415-436 misc placenta misc yolk sac misc Smith-Lemli-Opitz Syndrome misc low density lipoprotein misc high density lipoprotein misc liver X receptor misc Biochemistry
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title	Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster
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title_full	Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster
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author_browse	Katie T. Burke Perry L. Colvin Leslie Myatt Gregory A. Graf Friedhelm Schroeder Laura A. Woollett
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title_sort	transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden syrian hamster
callnumber	QD415-436
title_auth	Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster
abstract	The fetus has a high requirement for cholesterol and synthesizes cholesterol at elevated rates. Recent studies suggest that fetal cholesterol also can be obtained from exogenous sources. The purpose of the current study was to examine the transport of maternal cholesterol to the fetus and determine the mechanism responsible for any cholesterol-driven changes in transport. Studies were completed in pregnant hamsters with normal and elevated plasma cholesterol concentrations. Cholesterol feeding resulted in a 3.1-fold increase in the amount of LDL-cholesterol taken up by the fetus and a 2.4-fold increase in the amount of HDL-cholesterol taken up. LDL-cholesterol was transported to the fetus primarily by the placenta, and HDL-cholesterol was transported by the yolk sac and placenta. Several proteins associated with sterol transport and efflux, including those induced by activated liver X receptor, were expressed in hamster and human placentas: NPC1, NPC1L1, ABCA2, SCP-x, and ABCG1, but not ABCG8. NPC1L1 was the only protein increased in hypercholesterolemic placentas. Thus, increasing maternal lipoprotein-cholesterol concentrations can enhance transport of maternal cholesterol to the fetus, leading to 1) increased movement of cholesterol down a concentration gradient in the placenta, 2) increased lipoprotein secretion from the yolk sac (shown previously), and possibly 3) increased placental NPC1L1 expression.
abstractGer	The fetus has a high requirement for cholesterol and synthesizes cholesterol at elevated rates. Recent studies suggest that fetal cholesterol also can be obtained from exogenous sources. The purpose of the current study was to examine the transport of maternal cholesterol to the fetus and determine the mechanism responsible for any cholesterol-driven changes in transport. Studies were completed in pregnant hamsters with normal and elevated plasma cholesterol concentrations. Cholesterol feeding resulted in a 3.1-fold increase in the amount of LDL-cholesterol taken up by the fetus and a 2.4-fold increase in the amount of HDL-cholesterol taken up. LDL-cholesterol was transported to the fetus primarily by the placenta, and HDL-cholesterol was transported by the yolk sac and placenta. Several proteins associated with sterol transport and efflux, including those induced by activated liver X receptor, were expressed in hamster and human placentas: NPC1, NPC1L1, ABCA2, SCP-x, and ABCG1, but not ABCG8. NPC1L1 was the only protein increased in hypercholesterolemic placentas. Thus, increasing maternal lipoprotein-cholesterol concentrations can enhance transport of maternal cholesterol to the fetus, leading to 1) increased movement of cholesterol down a concentration gradient in the placenta, 2) increased lipoprotein secretion from the yolk sac (shown previously), and possibly 3) increased placental NPC1L1 expression.
abstract_unstemmed	The fetus has a high requirement for cholesterol and synthesizes cholesterol at elevated rates. Recent studies suggest that fetal cholesterol also can be obtained from exogenous sources. The purpose of the current study was to examine the transport of maternal cholesterol to the fetus and determine the mechanism responsible for any cholesterol-driven changes in transport. Studies were completed in pregnant hamsters with normal and elevated plasma cholesterol concentrations. Cholesterol feeding resulted in a 3.1-fold increase in the amount of LDL-cholesterol taken up by the fetus and a 2.4-fold increase in the amount of HDL-cholesterol taken up. LDL-cholesterol was transported to the fetus primarily by the placenta, and HDL-cholesterol was transported by the yolk sac and placenta. Several proteins associated with sterol transport and efflux, including those induced by activated liver X receptor, were expressed in hamster and human placentas: NPC1, NPC1L1, ABCA2, SCP-x, and ABCG1, but not ABCG8. NPC1L1 was the only protein increased in hypercholesterolemic placentas. Thus, increasing maternal lipoprotein-cholesterol concentrations can enhance transport of maternal cholesterol to the fetus, leading to 1) increased movement of cholesterol down a concentration gradient in the placenta, 2) increased lipoprotein secretion from the yolk sac (shown previously), and possibly 3) increased placental NPC1L1 expression.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster
url	https://doi.org/10.1194/jlr.M800538-JLR200 https://doaj.org/article/37b107b5baa1400e81236f2995647652 http://www.sciencedirect.com/science/article/pii/S0022227520308129 https://doaj.org/toc/0022-2275
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up_date	2024-07-04T00:37:22.526Z
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Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster

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