Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities

The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic n...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kai-Jin Wang [verfasserIn] Jin-Liang Zhao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy

Übergeordnetes Werk:	In: Biomedicine & Pharmacotherapy - Elsevier, 2021, 110(2019), Seite 510-517
Übergeordnetes Werk:	volume:110 ; year:2019 ; pages:510-517

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.biopha.2018.11.126

Katalog-ID:	DOAJ057191441

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ057191441
003	DE-627
005	20230308210405.0
007	cr uuu---uuuuu
008	230227s2019 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1016/j.biopha.2018.11.126 \|2 doi
035			\|a (DE-627)DOAJ057191441
035			\|a (DE-599)DOAJe902a4baa034422cad6f50259dff8aba
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RM1-950
100	0		\|a Kai-Jin Wang \|e verfasserin \|4 aut
245	1	0	\|a Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
264		1	\|c 2019
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN.
650		4	\|a Corn silk
650		4	\|a Antioxidant activity
650		4	\|a Anti-diabetic mellitus
650		4	\|a Anti-diabetic nephropathy
653		0	\|a Therapeutics. Pharmacology
700	0		\|a Jin-Liang Zhao \|e verfasserin \|4 aut
773	0	8	\|i In \|t Biomedicine & Pharmacotherapy \|d Elsevier, 2021 \|g 110(2019), Seite 510-517 \|w (DE-627)306717565 \|w (DE-600)1501510-5 \|x 19506007 \|7 nnns
773	1	8	\|g volume:110 \|g year:2019 \|g pages:510-517
856	4	0	\|u https://doi.org/10.1016/j.biopha.2018.11.126 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/e902a4baa034422cad6f50259dff8aba \|z kostenfrei
856	4	0	\|u http://www.sciencedirect.com/science/article/pii/S0753332218354404 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/0753-3322 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_165
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 110 \|j 2019 \|h 510-517

Indexfelder

author_variant	k j w kjw j l z jlz
matchkey_str	article:19506007:2019----::onikemylsucontrlnixdnsihmlsguoiaedacdlctoadibt
hierarchy_sort_str	2019
callnumber-subject-code	RM
publishDate	2019
allfields	10.1016/j.biopha.2018.11.126 doi (DE-627)DOAJ057191441 (DE-599)DOAJe902a4baa034422cad6f50259dff8aba DE-627 ger DE-627 rakwb eng RM1-950 Kai-Jin Wang verfasserin aut Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN. Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy Therapeutics. Pharmacology Jin-Liang Zhao verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 510-517 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:510-517 https://doi.org/10.1016/j.biopha.2018.11.126 kostenfrei https://doaj.org/article/e902a4baa034422cad6f50259dff8aba kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218354404 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 510-517
spelling	10.1016/j.biopha.2018.11.126 doi (DE-627)DOAJ057191441 (DE-599)DOAJe902a4baa034422cad6f50259dff8aba DE-627 ger DE-627 rakwb eng RM1-950 Kai-Jin Wang verfasserin aut Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN. Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy Therapeutics. Pharmacology Jin-Liang Zhao verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 510-517 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:510-517 https://doi.org/10.1016/j.biopha.2018.11.126 kostenfrei https://doaj.org/article/e902a4baa034422cad6f50259dff8aba kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218354404 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 510-517
allfields_unstemmed	10.1016/j.biopha.2018.11.126 doi (DE-627)DOAJ057191441 (DE-599)DOAJe902a4baa034422cad6f50259dff8aba DE-627 ger DE-627 rakwb eng RM1-950 Kai-Jin Wang verfasserin aut Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN. Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy Therapeutics. Pharmacology Jin-Liang Zhao verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 510-517 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:510-517 https://doi.org/10.1016/j.biopha.2018.11.126 kostenfrei https://doaj.org/article/e902a4baa034422cad6f50259dff8aba kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218354404 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 510-517
allfieldsGer	10.1016/j.biopha.2018.11.126 doi (DE-627)DOAJ057191441 (DE-599)DOAJe902a4baa034422cad6f50259dff8aba DE-627 ger DE-627 rakwb eng RM1-950 Kai-Jin Wang verfasserin aut Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN. Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy Therapeutics. Pharmacology Jin-Liang Zhao verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 510-517 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:510-517 https://doi.org/10.1016/j.biopha.2018.11.126 kostenfrei https://doaj.org/article/e902a4baa034422cad6f50259dff8aba kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218354404 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 510-517
allfieldsSound	10.1016/j.biopha.2018.11.126 doi (DE-627)DOAJ057191441 (DE-599)DOAJe902a4baa034422cad6f50259dff8aba DE-627 ger DE-627 rakwb eng RM1-950 Kai-Jin Wang verfasserin aut Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN. Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy Therapeutics. Pharmacology Jin-Liang Zhao verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 110(2019), Seite 510-517 (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:110 year:2019 pages:510-517 https://doi.org/10.1016/j.biopha.2018.11.126 kostenfrei https://doaj.org/article/e902a4baa034422cad6f50259dff8aba kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332218354404 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 110 2019 510-517
language	English
source	In Biomedicine & Pharmacotherapy 110(2019), Seite 510-517 volume:110 year:2019 pages:510-517
sourceStr	In Biomedicine & Pharmacotherapy 110(2019), Seite 510-517 volume:110 year:2019 pages:510-517
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Biomedicine & Pharmacotherapy
authorswithroles_txt_mv	Kai-Jin Wang @@aut@@ Jin-Liang Zhao @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	306717565
id	DOAJ057191441
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ057191441</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308210405.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2019 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.biopha.2018.11.126</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ057191441</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe902a4baa034422cad6f50259dff8aba</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Kai-Jin Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corn silk</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidant activity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-diabetic mellitus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-diabetic nephropathy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jin-Liang Zhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biomedicine & Pharmacotherapy</subfield><subfield code="d">Elsevier, 2021</subfield><subfield code="g">110(2019), Seite 510-517</subfield><subfield code="w">(DE-627)306717565</subfield><subfield code="w">(DE-600)1501510-5</subfield><subfield code="x">19506007</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:110</subfield><subfield code="g">year:2019</subfield><subfield code="g">pages:510-517</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.biopha.2018.11.126</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/e902a4baa034422cad6f50259dff8aba</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S0753332218354404</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/0753-3322</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_165</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">110</subfield><subfield code="j">2019</subfield><subfield code="h">510-517</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Kai-Jin Wang
spellingShingle	Kai-Jin Wang misc RM1-950 misc Corn silk misc Antioxidant activity misc Anti-diabetic mellitus misc Anti-diabetic nephropathy misc Therapeutics. Pharmacology Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
authorStr	Kai-Jin Wang
ppnlink_with_tag_str_mv	@@773@@(DE-627)306717565
format	electronic Article
delete_txt_mv	keep
author_role	aut aut
collection	DOAJ
remote_str	true
callnumber-label	RM1-950
illustrated	Not Illustrated
issn	19506007
topic_title	RM1-950 Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities Corn silk Antioxidant activity Anti-diabetic mellitus Anti-diabetic nephropathy
topic	misc RM1-950 misc Corn silk misc Antioxidant activity misc Anti-diabetic mellitus misc Anti-diabetic nephropathy misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Corn silk misc Antioxidant activity misc Anti-diabetic mellitus misc Anti-diabetic nephropathy misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc Corn silk misc Antioxidant activity misc Anti-diabetic mellitus misc Anti-diabetic nephropathy misc Therapeutics. Pharmacology
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Biomedicine & Pharmacotherapy
hierarchy_parent_id	306717565
hierarchy_top_title	Biomedicine & Pharmacotherapy
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)306717565 (DE-600)1501510-5
title	Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
ctrlnum	(DE-627)DOAJ057191441 (DE-599)DOAJe902a4baa034422cad6f50259dff8aba
title_full	Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
author_sort	Kai-Jin Wang
journal	Biomedicine & Pharmacotherapy
journalStr	Biomedicine & Pharmacotherapy
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2019
contenttype_str_mv	txt
container_start_page	510
author_browse	Kai-Jin Wang Jin-Liang Zhao
container_volume	110
class	RM1-950
format_se	Elektronische Aufsätze
author-letter	Kai-Jin Wang
doi_str_mv	10.1016/j.biopha.2018.11.126
author2-role	verfasserin
title_sort	corn silk (zea mays l.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
callnumber	RM1-950
title_auth	Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
abstract	The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN.
abstractGer	The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN.
abstract_unstemmed	The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities
url	https://doi.org/10.1016/j.biopha.2018.11.126 https://doaj.org/article/e902a4baa034422cad6f50259dff8aba http://www.sciencedirect.com/science/article/pii/S0753332218354404 https://doaj.org/toc/0753-3322
remote_bool	true
author2	Jin-Liang Zhao
author2Str	Jin-Liang Zhao
ppnlink	306717565
callnumber-subject	RM - Therapeutics and Pharmacology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1016/j.biopha.2018.11.126
callnumber-a	RM1-950
up_date	2024-07-04T00:41:29.075Z
_version_	1803607017078652928
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ057191441</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308210405.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2019 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.biopha.2018.11.126</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ057191441</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe902a4baa034422cad6f50259dff8aba</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Kai-Jin Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was liquid-liquid fractionated to get petroleum ether fraction (PCS), ethyl acetate fraction (ECS), n-butanol fraction (BCS) and water fraction (WCS). The Folin-Ciocalteu and AlCl3 assay showed that silk corn contained considerable amount of phenolics and flavonoids, ECS and BCS were the two phenolic-enriched fractions with highest TPC and TFC values. The ECS and BCS showed the highest total antioxidant activity and reducing power, as well as the strongest scavenging activity against DPPH and hydroxyl radicals, compared to CS and other fractions. The ECS and BCS displayed appreciable anti-hyperglycaemic effect indicated by the significant inhibition on α-amylase and α-glucosidase in enzymatic assays. In BSA-glucose model, ECS and BCS effectively inhibited the formation of advanced glycation end products (AGEs). In addition, the anti-diabetic nephropathy activity assay displayed that CS, ECS and BCS significantly inhibited the production of Col IV, FN and IL-6 in high-glucose stimulated mesangial cells at 200 μg/mL. These findings suggested the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on DM and DN. The phenolic-enriched CS fractions could be considered as a source of natural antioxidants and further developed for the prevention and treatment of DM and its complications including DN.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corn silk</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidant activity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-diabetic mellitus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-diabetic nephropathy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jin-Liang Zhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biomedicine & Pharmacotherapy</subfield><subfield code="d">Elsevier, 2021</subfield><subfield code="g">110(2019), Seite 510-517</subfield><subfield code="w">(DE-627)306717565</subfield><subfield code="w">(DE-600)1501510-5</subfield><subfield code="x">19506007</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:110</subfield><subfield code="g">year:2019</subfield><subfield code="g">pages:510-517</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.biopha.2018.11.126</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/e902a4baa034422cad6f50259dff8aba</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S0753332218354404</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/0753-3322</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_165</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">110</subfield><subfield code="j">2019</subfield><subfield code="h">510-517</subfield></datafield></record></collection>
score	7.401886

Nicht das Richtige dabei?

Schreiben Sie uns!

Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?