Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients
The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of...
Ausführliche Beschreibung
Autor*in: |
André Moreira-Rosário [verfasserIn] Cláudia Marques [verfasserIn] Hélder Pinheiro [verfasserIn] João Ricardo Araújo [verfasserIn] Pedro Ribeiro [verfasserIn] Rita Rocha [verfasserIn] Inês Mota [verfasserIn] Diogo Pestana [verfasserIn] Rita Ribeiro [verfasserIn] Ana Pereira [verfasserIn] Maria José de Sousa [verfasserIn] José Pereira-Leal [verfasserIn] José de Sousa [verfasserIn] Juliana Morais [verfasserIn] Diana Teixeira [verfasserIn] Júlio César Rocha [verfasserIn] Marta Silvestre [verfasserIn] Nuno Príncipe [verfasserIn] Nuno Gatta [verfasserIn] José Amado [verfasserIn] Lurdes Santos [verfasserIn] Fernando Maltez [verfasserIn] Ana Boquinhas [verfasserIn] Germano de Sousa [verfasserIn] Nuno Germano [verfasserIn] Gonçalo Sarmento [verfasserIn] Cristina Granja [verfasserIn] Pedro Póvoa [verfasserIn] Ana Faria [verfasserIn] Conceição Calhau [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
WHO Clinical Progression Scale |
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Übergeordnetes Werk: |
In: Frontiers in Microbiology - Frontiers Media S.A., 2011, 12(2021) |
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Übergeordnetes Werk: |
volume:12 ; year:2021 |
Links: |
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DOI / URN: |
10.3389/fmicb.2021.705020 |
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Katalog-ID: |
DOAJ057236925 |
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520 | |a The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. | ||
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10.3389/fmicb.2021.705020 doi (DE-627)DOAJ057236925 (DE-599)DOAJ9c3a1a2aefc14b51a089bbbe7c233b2e DE-627 ger DE-627 rakwb eng QR1-502 André Moreira-Rosário verfasserin aut Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. COVID-19 WHO Clinical Progression Scale Shannon—Weiner diversity index dysbiosis gut microbiota Microbiology André Moreira-Rosário verfasserin aut Cláudia Marques verfasserin aut Cláudia Marques verfasserin aut Hélder Pinheiro verfasserin aut Hélder Pinheiro verfasserin aut João Ricardo Araújo verfasserin aut João Ricardo Araújo verfasserin aut Pedro Ribeiro verfasserin aut Rita Rocha verfasserin aut Rita Rocha verfasserin aut Inês Mota verfasserin aut Inês Mota verfasserin aut Diogo Pestana verfasserin aut Diogo Pestana verfasserin aut Rita Ribeiro verfasserin aut Ana Pereira verfasserin aut Maria José de Sousa verfasserin aut Maria José de Sousa verfasserin aut José Pereira-Leal verfasserin aut José de Sousa verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Diana Teixeira verfasserin aut Diana Teixeira verfasserin aut Júlio César Rocha verfasserin aut Júlio César Rocha verfasserin aut Marta Silvestre verfasserin aut Marta Silvestre verfasserin aut Nuno Príncipe verfasserin aut Nuno Gatta verfasserin aut José Amado verfasserin aut Lurdes Santos verfasserin aut Fernando Maltez verfasserin aut Ana Boquinhas verfasserin aut Germano de Sousa verfasserin aut Nuno Germano verfasserin aut Gonçalo Sarmento verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Ana Faria verfasserin aut Ana Faria verfasserin aut Conceição Calhau verfasserin aut Conceição Calhau verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 12(2021) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:12 year:2021 https://doi.org/10.3389/fmicb.2021.705020 kostenfrei https://doaj.org/article/9c3a1a2aefc14b51a089bbbe7c233b2e kostenfrei https://www.frontiersin.org/articles/10.3389/fmicb.2021.705020/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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10.3389/fmicb.2021.705020 doi (DE-627)DOAJ057236925 (DE-599)DOAJ9c3a1a2aefc14b51a089bbbe7c233b2e DE-627 ger DE-627 rakwb eng QR1-502 André Moreira-Rosário verfasserin aut Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. COVID-19 WHO Clinical Progression Scale Shannon—Weiner diversity index dysbiosis gut microbiota Microbiology André Moreira-Rosário verfasserin aut Cláudia Marques verfasserin aut Cláudia Marques verfasserin aut Hélder Pinheiro verfasserin aut Hélder Pinheiro verfasserin aut João Ricardo Araújo verfasserin aut João Ricardo Araújo verfasserin aut Pedro Ribeiro verfasserin aut Rita Rocha verfasserin aut Rita Rocha verfasserin aut Inês Mota verfasserin aut Inês Mota verfasserin aut Diogo Pestana verfasserin aut Diogo Pestana verfasserin aut Rita Ribeiro verfasserin aut Ana Pereira verfasserin aut Maria José de Sousa verfasserin aut Maria José de Sousa verfasserin aut José Pereira-Leal verfasserin aut José de Sousa verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Diana Teixeira verfasserin aut Diana Teixeira verfasserin aut Júlio César Rocha verfasserin aut Júlio César Rocha verfasserin aut Marta Silvestre verfasserin aut Marta Silvestre verfasserin aut Nuno Príncipe verfasserin aut Nuno Gatta verfasserin aut José Amado verfasserin aut Lurdes Santos verfasserin aut Fernando Maltez verfasserin aut Ana Boquinhas verfasserin aut Germano de Sousa verfasserin aut Nuno Germano verfasserin aut Gonçalo Sarmento verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Ana Faria verfasserin aut Ana Faria verfasserin aut Conceição Calhau verfasserin aut Conceição Calhau verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 12(2021) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:12 year:2021 https://doi.org/10.3389/fmicb.2021.705020 kostenfrei https://doaj.org/article/9c3a1a2aefc14b51a089bbbe7c233b2e kostenfrei https://www.frontiersin.org/articles/10.3389/fmicb.2021.705020/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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10.3389/fmicb.2021.705020 doi (DE-627)DOAJ057236925 (DE-599)DOAJ9c3a1a2aefc14b51a089bbbe7c233b2e DE-627 ger DE-627 rakwb eng QR1-502 André Moreira-Rosário verfasserin aut Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. COVID-19 WHO Clinical Progression Scale Shannon—Weiner diversity index dysbiosis gut microbiota Microbiology André Moreira-Rosário verfasserin aut Cláudia Marques verfasserin aut Cláudia Marques verfasserin aut Hélder Pinheiro verfasserin aut Hélder Pinheiro verfasserin aut João Ricardo Araújo verfasserin aut João Ricardo Araújo verfasserin aut Pedro Ribeiro verfasserin aut Rita Rocha verfasserin aut Rita Rocha verfasserin aut Inês Mota verfasserin aut Inês Mota verfasserin aut Diogo Pestana verfasserin aut Diogo Pestana verfasserin aut Rita Ribeiro verfasserin aut Ana Pereira verfasserin aut Maria José de Sousa verfasserin aut Maria José de Sousa verfasserin aut José Pereira-Leal verfasserin aut José de Sousa verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Diana Teixeira verfasserin aut Diana Teixeira verfasserin aut Júlio César Rocha verfasserin aut Júlio César Rocha verfasserin aut Marta Silvestre verfasserin aut Marta Silvestre verfasserin aut Nuno Príncipe verfasserin aut Nuno Gatta verfasserin aut José Amado verfasserin aut Lurdes Santos verfasserin aut Fernando Maltez verfasserin aut Ana Boquinhas verfasserin aut Germano de Sousa verfasserin aut Nuno Germano verfasserin aut Gonçalo Sarmento verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Ana Faria verfasserin aut Ana Faria verfasserin aut Conceição Calhau verfasserin aut Conceição Calhau verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 12(2021) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:12 year:2021 https://doi.org/10.3389/fmicb.2021.705020 kostenfrei https://doaj.org/article/9c3a1a2aefc14b51a089bbbe7c233b2e kostenfrei https://www.frontiersin.org/articles/10.3389/fmicb.2021.705020/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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10.3389/fmicb.2021.705020 doi (DE-627)DOAJ057236925 (DE-599)DOAJ9c3a1a2aefc14b51a089bbbe7c233b2e DE-627 ger DE-627 rakwb eng QR1-502 André Moreira-Rosário verfasserin aut Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. COVID-19 WHO Clinical Progression Scale Shannon—Weiner diversity index dysbiosis gut microbiota Microbiology André Moreira-Rosário verfasserin aut Cláudia Marques verfasserin aut Cláudia Marques verfasserin aut Hélder Pinheiro verfasserin aut Hélder Pinheiro verfasserin aut João Ricardo Araújo verfasserin aut João Ricardo Araújo verfasserin aut Pedro Ribeiro verfasserin aut Rita Rocha verfasserin aut Rita Rocha verfasserin aut Inês Mota verfasserin aut Inês Mota verfasserin aut Diogo Pestana verfasserin aut Diogo Pestana verfasserin aut Rita Ribeiro verfasserin aut Ana Pereira verfasserin aut Maria José de Sousa verfasserin aut Maria José de Sousa verfasserin aut José Pereira-Leal verfasserin aut José de Sousa verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Diana Teixeira verfasserin aut Diana Teixeira verfasserin aut Júlio César Rocha verfasserin aut Júlio César Rocha verfasserin aut Marta Silvestre verfasserin aut Marta Silvestre verfasserin aut Nuno Príncipe verfasserin aut Nuno Gatta verfasserin aut José Amado verfasserin aut Lurdes Santos verfasserin aut Fernando Maltez verfasserin aut Ana Boquinhas verfasserin aut Germano de Sousa verfasserin aut Nuno Germano verfasserin aut Gonçalo Sarmento verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Ana Faria verfasserin aut Ana Faria verfasserin aut Conceição Calhau verfasserin aut Conceição Calhau verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 12(2021) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:12 year:2021 https://doi.org/10.3389/fmicb.2021.705020 kostenfrei https://doaj.org/article/9c3a1a2aefc14b51a089bbbe7c233b2e kostenfrei https://www.frontiersin.org/articles/10.3389/fmicb.2021.705020/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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10.3389/fmicb.2021.705020 doi (DE-627)DOAJ057236925 (DE-599)DOAJ9c3a1a2aefc14b51a089bbbe7c233b2e DE-627 ger DE-627 rakwb eng QR1-502 André Moreira-Rosário verfasserin aut Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. COVID-19 WHO Clinical Progression Scale Shannon—Weiner diversity index dysbiosis gut microbiota Microbiology André Moreira-Rosário verfasserin aut Cláudia Marques verfasserin aut Cláudia Marques verfasserin aut Hélder Pinheiro verfasserin aut Hélder Pinheiro verfasserin aut João Ricardo Araújo verfasserin aut João Ricardo Araújo verfasserin aut Pedro Ribeiro verfasserin aut Rita Rocha verfasserin aut Rita Rocha verfasserin aut Inês Mota verfasserin aut Inês Mota verfasserin aut Diogo Pestana verfasserin aut Diogo Pestana verfasserin aut Rita Ribeiro verfasserin aut Ana Pereira verfasserin aut Maria José de Sousa verfasserin aut Maria José de Sousa verfasserin aut José Pereira-Leal verfasserin aut José de Sousa verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Juliana Morais verfasserin aut Diana Teixeira verfasserin aut Diana Teixeira verfasserin aut Júlio César Rocha verfasserin aut Júlio César Rocha verfasserin aut Marta Silvestre verfasserin aut Marta Silvestre verfasserin aut Nuno Príncipe verfasserin aut Nuno Gatta verfasserin aut José Amado verfasserin aut Lurdes Santos verfasserin aut Fernando Maltez verfasserin aut Ana Boquinhas verfasserin aut Germano de Sousa verfasserin aut Nuno Germano verfasserin aut Gonçalo Sarmento verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Cristina Granja verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Pedro Póvoa verfasserin aut Ana Faria verfasserin aut Ana Faria verfasserin aut Conceição Calhau verfasserin aut Conceição Calhau verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 12(2021) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:12 year:2021 https://doi.org/10.3389/fmicb.2021.705020 kostenfrei https://doaj.org/article/9c3a1a2aefc14b51a089bbbe7c233b2e kostenfrei https://www.frontiersin.org/articles/10.3389/fmicb.2021.705020/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 |
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André Moreira-Rosário @@aut@@ Cláudia Marques @@aut@@ Hélder Pinheiro @@aut@@ João Ricardo Araújo @@aut@@ Pedro Ribeiro @@aut@@ Rita Rocha @@aut@@ Inês Mota @@aut@@ Diogo Pestana @@aut@@ Rita Ribeiro @@aut@@ Ana Pereira @@aut@@ Maria José de Sousa @@aut@@ José Pereira-Leal @@aut@@ José de Sousa @@aut@@ Juliana Morais @@aut@@ Diana Teixeira @@aut@@ Júlio César Rocha @@aut@@ Marta Silvestre @@aut@@ Nuno Príncipe @@aut@@ Nuno Gatta @@aut@@ José Amado @@aut@@ Lurdes Santos @@aut@@ Fernando Maltez @@aut@@ Ana Boquinhas @@aut@@ Germano de Sousa @@aut@@ Nuno Germano @@aut@@ Gonçalo Sarmento @@aut@@ Cristina Granja @@aut@@ Pedro Póvoa @@aut@@ Ana Faria @@aut@@ Conceição Calhau @@aut@@ |
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In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). 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André Moreira-Rosário Cláudia Marques Hélder Pinheiro João Ricardo Araújo Pedro Ribeiro Rita Rocha Inês Mota Diogo Pestana Rita Ribeiro Ana Pereira Maria José de Sousa José Pereira-Leal José de Sousa Juliana Morais Diana Teixeira Júlio César Rocha Marta Silvestre Nuno Príncipe Nuno Gatta José Amado Lurdes Santos Fernando Maltez Ana Boquinhas Germano de Sousa Nuno Germano Gonçalo Sarmento Cristina Granja Pedro Póvoa Ana Faria Conceição Calhau |
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gut microbiota diversity and c-reactive protein are predictors of disease severity in covid-19 patients |
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Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
abstract |
The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. |
abstractGer |
The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. |
abstract_unstemmed |
The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale—mild, 19 (16.5%); moderate, 37 (32.2%); or severe, 59 (51.3%), and (2) the location of recovery from COVID-19—ambulatory, 14 (household isolation, 12.2%); hospitalized in ward, 40 (34.8%); or hospitalized in the intensive care unit, 61 (53.0%). Gut microbiota analysis was performed through 16S rRNA gene sequencing, and the data obtained were further related to the clinical parameters of COVID-19 patients. The risk factors for COVID-19 severity were identified by univariate and multivariable logistic regression models. In comparison to mild COVID-19 patients, the gut microbiota of moderate and severe patients have: (a) lower Firmicutes/Bacteroidetes ratio; (b) higher abundance of Proteobacteria; and (c) lower abundance of beneficial butyrate-producing bacteria such as the genera Roseburia and Lachnospira. Multivariable regression analysis showed that the Shannon diversity index [odds ratio (OR) = 2.85, 95% CI = 1.09–7.41, p = 0.032) and C-reactive protein (OR = 3.45, 95% CI = 1.33–8.91, p = 0.011) are risk factors for severe COVID-19 (a score of 6 or higher in the WHO Clinical Progression Scale). In conclusion, our results demonstrated that hospitalized patients with moderate and severe COVID-19 have microbial signatures of gut dysbiosis; for the first time, the gut microbiota diversity is pointed out as a prognostic biomarker of COVID-19 severity. |
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title_short |
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients |
url |
https://doi.org/10.3389/fmicb.2021.705020 https://doaj.org/article/9c3a1a2aefc14b51a089bbbe7c233b2e https://www.frontiersin.org/articles/10.3389/fmicb.2021.705020/full https://doaj.org/toc/1664-302X |
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author2 |
André Moreira-Rosário Cláudia Marques Hélder Pinheiro João Ricardo Araújo Pedro Ribeiro Rita Rocha Inês Mota Diogo Pestana Rita Ribeiro Ana Pereira Maria José de Sousa José Pereira-Leal José de Sousa Juliana Morais Diana Teixeira Júlio César Rocha Marta Silvestre Nuno Príncipe Nuno Gatta José Amado Lurdes Santos Fernando Maltez Ana Boquinhas Germano de Sousa Nuno Germano Gonçalo Sarmento Cristina Granja Pedro Póvoa Ana Faria Conceição Calhau |
author2Str |
André Moreira-Rosário Cláudia Marques Hélder Pinheiro João Ricardo Araújo Pedro Ribeiro Rita Rocha Inês Mota Diogo Pestana Rita Ribeiro Ana Pereira Maria José de Sousa José Pereira-Leal José de Sousa Juliana Morais Diana Teixeira Júlio César Rocha Marta Silvestre Nuno Príncipe Nuno Gatta José Amado Lurdes Santos Fernando Maltez Ana Boquinhas Germano de Sousa Nuno Germano Gonçalo Sarmento Cristina Granja Pedro Póvoa Ana Faria Conceição Calhau |
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10.3389/fmicb.2021.705020 |
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up_date |
2024-07-04T00:52:12.016Z |
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