TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling

VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, gene...
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Autor*in:	Elena Bresciani [verfasserIn] Roberta Possenti [verfasserIn] Silvia Coco [verfasserIn] Laura Rizzi [verfasserIn] Ramona Meanti [verfasserIn] Laura Molteni [verfasserIn] Vittorio Locatelli [verfasserIn] Antonio Torsello [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	vgf tlqp-21 calcium (ca endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2019), 1, p 130
Übergeordnetes Werk:	volume:21 ; year:2019 ; number:1, p 130

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms21010130

Katalog-ID:	DOAJ05738911X

Internformat


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allfields	10.3390/ijms21010130 doi (DE-627)DOAJ05738911X (DE-599)DOAJc82035ceaeec49fa85534feb7d3f33a7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Bresciani verfasserin aut TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions. vgf tlqp-21 calcium (ca<sup<2+</sup<) endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current Biology (General) Chemistry Roberta Possenti verfasserin aut Silvia Coco verfasserin aut Laura Rizzi verfasserin aut Ramona Meanti verfasserin aut Laura Molteni verfasserin aut Vittorio Locatelli verfasserin aut Antonio Torsello verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2019), 1, p 130 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2019 number:1, p 130 https://doi.org/10.3390/ijms21010130 kostenfrei https://doaj.org/article/c82035ceaeec49fa85534feb7d3f33a7 kostenfrei https://www.mdpi.com/1422-0067/21/1/130 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2019 1, p 130
spelling	10.3390/ijms21010130 doi (DE-627)DOAJ05738911X (DE-599)DOAJc82035ceaeec49fa85534feb7d3f33a7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Bresciani verfasserin aut TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions. vgf tlqp-21 calcium (ca<sup<2+</sup<) endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current Biology (General) Chemistry Roberta Possenti verfasserin aut Silvia Coco verfasserin aut Laura Rizzi verfasserin aut Ramona Meanti verfasserin aut Laura Molteni verfasserin aut Vittorio Locatelli verfasserin aut Antonio Torsello verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2019), 1, p 130 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2019 number:1, p 130 https://doi.org/10.3390/ijms21010130 kostenfrei https://doaj.org/article/c82035ceaeec49fa85534feb7d3f33a7 kostenfrei https://www.mdpi.com/1422-0067/21/1/130 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2019 1, p 130
allfields_unstemmed	10.3390/ijms21010130 doi (DE-627)DOAJ05738911X (DE-599)DOAJc82035ceaeec49fa85534feb7d3f33a7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Bresciani verfasserin aut TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions. vgf tlqp-21 calcium (ca<sup<2+</sup<) endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current Biology (General) Chemistry Roberta Possenti verfasserin aut Silvia Coco verfasserin aut Laura Rizzi verfasserin aut Ramona Meanti verfasserin aut Laura Molteni verfasserin aut Vittorio Locatelli verfasserin aut Antonio Torsello verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2019), 1, p 130 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2019 number:1, p 130 https://doi.org/10.3390/ijms21010130 kostenfrei https://doaj.org/article/c82035ceaeec49fa85534feb7d3f33a7 kostenfrei https://www.mdpi.com/1422-0067/21/1/130 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2019 1, p 130
allfieldsGer	10.3390/ijms21010130 doi (DE-627)DOAJ05738911X (DE-599)DOAJc82035ceaeec49fa85534feb7d3f33a7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Bresciani verfasserin aut TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions. vgf tlqp-21 calcium (ca<sup<2+</sup<) endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current Biology (General) Chemistry Roberta Possenti verfasserin aut Silvia Coco verfasserin aut Laura Rizzi verfasserin aut Ramona Meanti verfasserin aut Laura Molteni verfasserin aut Vittorio Locatelli verfasserin aut Antonio Torsello verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2019), 1, p 130 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2019 number:1, p 130 https://doi.org/10.3390/ijms21010130 kostenfrei https://doaj.org/article/c82035ceaeec49fa85534feb7d3f33a7 kostenfrei https://www.mdpi.com/1422-0067/21/1/130 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2019 1, p 130
allfieldsSound	10.3390/ijms21010130 doi (DE-627)DOAJ05738911X (DE-599)DOAJc82035ceaeec49fa85534feb7d3f33a7 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Elena Bresciani verfasserin aut TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions. vgf tlqp-21 calcium (ca<sup<2+</sup<) endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current Biology (General) Chemistry Roberta Possenti verfasserin aut Silvia Coco verfasserin aut Laura Rizzi verfasserin aut Ramona Meanti verfasserin aut Laura Molteni verfasserin aut Vittorio Locatelli verfasserin aut Antonio Torsello verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2019), 1, p 130 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2019 number:1, p 130 https://doi.org/10.3390/ijms21010130 kostenfrei https://doaj.org/article/c82035ceaeec49fa85534feb7d3f33a7 kostenfrei https://www.mdpi.com/1422-0067/21/1/130 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2019 1, p 130
language	English
source	In International Journal of Molecular Sciences 21(2019), 1, p 130 volume:21 year:2019 number:1, p 130
sourceStr	In International Journal of Molecular Sciences 21(2019), 1, p 130 volume:21 year:2019 number:1, p 130
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	vgf tlqp-21 calcium (ca<sup<2+</sup<) endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Elena Bresciani @@aut@@ Roberta Possenti @@aut@@ Silvia Coco @@aut@@ Laura Rizzi @@aut@@ Ramona Meanti @@aut@@ Laura Molteni @@aut@@ Vittorio Locatelli @@aut@@ Antonio Torsello @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ05738911X
language_de	englisch
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callnumber-first	Q - Science
author	Elena Bresciani
spellingShingle	Elena Bresciani misc QH301-705.5 misc QD1-999 misc vgf misc tlqp-21 misc calcium (ca<sup<2+</sup<) misc endocrine misc extraendocrine misc complement c3a receptor-1 (c3ar1) misc stromal interaction molecules (stim) misc calcium release-activated calcium channel (crac)-orai1 misc transient receptor potential channel (trpc) misc kca3.1 current misc Biology (General) misc Chemistry TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling
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topic_title	QH301-705.5 QD1-999 TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling vgf tlqp-21 calcium (ca<sup<2+</sup<) endocrine extraendocrine complement c3a receptor-1 (c3ar1) stromal interaction molecules (stim) calcium release-activated calcium channel (crac)-orai1 transient receptor potential channel (trpc) kca3.1 current
topic	misc QH301-705.5 misc QD1-999 misc vgf misc tlqp-21 misc calcium (ca<sup<2+</sup<) misc endocrine misc extraendocrine misc complement c3a receptor-1 (c3ar1) misc stromal interaction molecules (stim) misc calcium release-activated calcium channel (crac)-orai1 misc transient receptor potential channel (trpc) misc kca3.1 current misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc vgf misc tlqp-21 misc calcium (ca<sup<2+</sup<) misc endocrine misc extraendocrine misc complement c3a receptor-1 (c3ar1) misc stromal interaction molecules (stim) misc calcium release-activated calcium channel (crac)-orai1 misc transient receptor potential channel (trpc) misc kca3.1 current misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc vgf misc tlqp-21 misc calcium (ca<sup<2+</sup<) misc endocrine misc extraendocrine misc complement c3a receptor-1 (c3ar1) misc stromal interaction molecules (stim) misc calcium release-activated calcium channel (crac)-orai1 misc transient receptor potential channel (trpc) misc kca3.1 current misc Biology (General) misc Chemistry
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title	TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling
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title_full	TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling
author_sort	Elena Bresciani
journal	International Journal of Molecular Sciences
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author_browse	Elena Bresciani Roberta Possenti Silvia Coco Laura Rizzi Ramona Meanti Laura Molteni Vittorio Locatelli Antonio Torsello
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author-letter	Elena Bresciani
doi_str_mv	10.3390/ijms21010130
author2-role	verfasserin
title_sort	tlqp-21, a vgf-derived peptide endowed of endocrine and extraendocrine properties: focus on in vitro calcium signaling
callnumber	QH301-705.5
title_auth	TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling
abstract	VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions.
abstractGer	VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions.
abstract_unstemmed	VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca<sup<2+</sup<. This effect relies both on Ca<sup<2+</sup< release from the endoplasmic reticulum (ER) and extracellular Ca<sup<2+</sup< entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca<sup<2+</sup< entry, the activation of outward K<sup<+</sup<-Ca<sup<2+</sup<-dependent currents, mainly the K<sub<Ca3.1</sub< currents, provides a membrane polarizing influence which offset the depolarizing action of Ca<sup<2+</sup< elevation and indirectly maintains the driving force for optimal Ca<sup<2+</sup< increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions.
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title_short	TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling
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TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling

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