Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study

Volume-stable collagen matrices (VSCM) are conductive for the connective tissue upon soft tissue augmentation. Considering that collagen has osteoconductive properties, we have investigated the possibility that the VSCM also consolidates with the newly formed bone. To this end, we covered nine rat c...
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Autor*in:	Karol Alí Apaza Alccayhuaman [verfasserIn] Stefan Tangl [verfasserIn] Stéphane Blouin [verfasserIn] Markus A. Hartmann [verfasserIn] Patrick Heimel [verfasserIn] Ulrike Kuchler [verfasserIn] Jung-Seok Lee [verfasserIn] Reinhard Gruber [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	bone regeneration volume-stable collagen matrix collagen matrix histology qBEI

Übergeordnetes Werk:	In: Biomedicines - MDPI AG, 2014, 9(2021), 7, p 732
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:7, p 732

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomedicines9070732

Katalog-ID:	DOAJ057481903

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callnumber-first	Q - Science
author	Karol Alí Apaza Alccayhuaman
spellingShingle	Karol Alí Apaza Alccayhuaman misc QH301-705.5 misc bone regeneration misc volume-stable collagen matrix misc collagen matrix misc histology misc qBEI misc Biology (General) Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study
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topic_title	QH301-705.5 Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study bone regeneration volume-stable collagen matrix collagen matrix histology qBEI
topic	misc QH301-705.5 misc bone regeneration misc volume-stable collagen matrix misc collagen matrix misc histology misc qBEI misc Biology (General)
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title	Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study
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title_full	Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study
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title_sort	osteoconductive properties of a volume-stable collagen matrix in rat calvaria defects: a pilot study
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title_auth	Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study
abstract	Volume-stable collagen matrices (VSCM) are conductive for the connective tissue upon soft tissue augmentation. Considering that collagen has osteoconductive properties, we have investigated the possibility that the VSCM also consolidates with the newly formed bone. To this end, we covered nine rat calvaria circular defects with a VSCM. After four weeks, histology, histomorphometry, quantitative backscattered electron imaging, and microcomputed tomography were performed. We report that the overall pattern of mineralization inside the VSCM was heterogeneous. Histology revealed, apart from the characteristic woven bone formation, areas of round-shaped hypertrophic chondrocyte-like cells surrounded by a mineralized extracellular matrix. Quantitative backscattered electron imaging confirmed the heterogenous mineralization occurring within the VSCM. Histomorphometry found new bone to be 0.7 mm<sup<2</sup< (0.01 min; 2.4 max), similar to the chondrogenic mineralized extracellular matrix with 0.7 mm<sup<2</sup< (0.0 min; 4.2 max). Microcomputed tomography showed the overall mineralized tissue in the defect to be 1.6 mm<sup<3</sup< (min 0.0; max 13.3). These findings suggest that in a rat cranial defect, VSCM has a limited and heterogeneous capacity to support intramembranous bone formation but may allow the formation of bone via the endochondral route.
abstractGer	Volume-stable collagen matrices (VSCM) are conductive for the connective tissue upon soft tissue augmentation. Considering that collagen has osteoconductive properties, we have investigated the possibility that the VSCM also consolidates with the newly formed bone. To this end, we covered nine rat calvaria circular defects with a VSCM. After four weeks, histology, histomorphometry, quantitative backscattered electron imaging, and microcomputed tomography were performed. We report that the overall pattern of mineralization inside the VSCM was heterogeneous. Histology revealed, apart from the characteristic woven bone formation, areas of round-shaped hypertrophic chondrocyte-like cells surrounded by a mineralized extracellular matrix. Quantitative backscattered electron imaging confirmed the heterogenous mineralization occurring within the VSCM. Histomorphometry found new bone to be 0.7 mm<sup<2</sup< (0.01 min; 2.4 max), similar to the chondrogenic mineralized extracellular matrix with 0.7 mm<sup<2</sup< (0.0 min; 4.2 max). Microcomputed tomography showed the overall mineralized tissue in the defect to be 1.6 mm<sup<3</sup< (min 0.0; max 13.3). These findings suggest that in a rat cranial defect, VSCM has a limited and heterogeneous capacity to support intramembranous bone formation but may allow the formation of bone via the endochondral route.
abstract_unstemmed	Volume-stable collagen matrices (VSCM) are conductive for the connective tissue upon soft tissue augmentation. Considering that collagen has osteoconductive properties, we have investigated the possibility that the VSCM also consolidates with the newly formed bone. To this end, we covered nine rat calvaria circular defects with a VSCM. After four weeks, histology, histomorphometry, quantitative backscattered electron imaging, and microcomputed tomography were performed. We report that the overall pattern of mineralization inside the VSCM was heterogeneous. Histology revealed, apart from the characteristic woven bone formation, areas of round-shaped hypertrophic chondrocyte-like cells surrounded by a mineralized extracellular matrix. Quantitative backscattered electron imaging confirmed the heterogenous mineralization occurring within the VSCM. Histomorphometry found new bone to be 0.7 mm<sup<2</sup< (0.01 min; 2.4 max), similar to the chondrogenic mineralized extracellular matrix with 0.7 mm<sup<2</sup< (0.0 min; 4.2 max). Microcomputed tomography showed the overall mineralized tissue in the defect to be 1.6 mm<sup<3</sup< (min 0.0; max 13.3). These findings suggest that in a rat cranial defect, VSCM has a limited and heterogeneous capacity to support intramembranous bone formation but may allow the formation of bone via the endochondral route.
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title_short	Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study
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Microcomputed tomography showed the overall mineralized tissue in the defect to be 1.6 mm<sup<3</sup< (min 0.0; max 13.3). 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Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study

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