Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters...
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Autor*in:	Fiorella D’Onofrio [verfasserIn] Giorgia Renga [verfasserIn] Matteo Puccetti [verfasserIn] Marilena Pariano [verfasserIn] Marina Maria Bellet [verfasserIn] Ilaria Santarelli [verfasserIn] Claudia Stincardini [verfasserIn] Paolo Mosci [verfasserIn] Maurizio Ricci [verfasserIn] Stefano Giovagnoli [verfasserIn] Claudio Costantini [verfasserIn] Luigina Romani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	primary sclerosing cholangitis aryl hydrocarbon receptor indole-3-carboxaldehyde mucosal barrier microbiota

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 10(2021), 7, p 1622
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:7, p 1622

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells10071622

Katalog-ID:	DOAJ057485585

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520			\|a Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. This study points to the therapeutic potential of 3-IAld in liver pathology.
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allfields	10.3390/cells10071622 doi (DE-627)DOAJ057485585 (DE-599)DOAJa8df52a440f549719ddba6107ac9c9bc DE-627 ger DE-627 rakwb eng QH573-671 Fiorella D’Onofrio verfasserin aut Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. This study points to the therapeutic potential of 3-IAld in liver pathology. primary sclerosing cholangitis aryl hydrocarbon receptor indole-3-carboxaldehyde mucosal barrier microbiota Cytology Giorgia Renga verfasserin aut Matteo Puccetti verfasserin aut Marilena Pariano verfasserin aut Marina Maria Bellet verfasserin aut Ilaria Santarelli verfasserin aut Claudia Stincardini verfasserin aut Paolo Mosci verfasserin aut Maurizio Ricci verfasserin aut Stefano Giovagnoli verfasserin aut Claudio Costantini verfasserin aut Luigina Romani verfasserin aut In Cells MDPI AG, 2012 10(2021), 7, p 1622 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:7, p 1622 https://doi.org/10.3390/cells10071622 kostenfrei https://doaj.org/article/a8df52a440f549719ddba6107ac9c9bc kostenfrei https://www.mdpi.com/2073-4409/10/7/1622 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 7, p 1622
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allfieldsSound	10.3390/cells10071622 doi (DE-627)DOAJ057485585 (DE-599)DOAJa8df52a440f549719ddba6107ac9c9bc DE-627 ger DE-627 rakwb eng QH573-671 Fiorella D’Onofrio verfasserin aut Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. This study points to the therapeutic potential of 3-IAld in liver pathology. primary sclerosing cholangitis aryl hydrocarbon receptor indole-3-carboxaldehyde mucosal barrier microbiota Cytology Giorgia Renga verfasserin aut Matteo Puccetti verfasserin aut Marilena Pariano verfasserin aut Marina Maria Bellet verfasserin aut Ilaria Santarelli verfasserin aut Claudia Stincardini verfasserin aut Paolo Mosci verfasserin aut Maurizio Ricci verfasserin aut Stefano Giovagnoli verfasserin aut Claudio Costantini verfasserin aut Luigina Romani verfasserin aut In Cells MDPI AG, 2012 10(2021), 7, p 1622 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:10 year:2021 number:7, p 1622 https://doi.org/10.3390/cells10071622 kostenfrei https://doaj.org/article/a8df52a440f549719ddba6107ac9c9bc kostenfrei https://www.mdpi.com/2073-4409/10/7/1622 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 7, p 1622
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source	In Cells 10(2021), 7, p 1622 volume:10 year:2021 number:7, p 1622
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authorswithroles_txt_mv	Fiorella D’Onofrio @@aut@@ Giorgia Renga @@aut@@ Matteo Puccetti @@aut@@ Marilena Pariano @@aut@@ Marina Maria Bellet @@aut@@ Ilaria Santarelli @@aut@@ Claudia Stincardini @@aut@@ Paolo Mosci @@aut@@ Maurizio Ricci @@aut@@ Stefano Giovagnoli @@aut@@ Claudio Costantini @@aut@@ Luigina Romani @@aut@@
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callnumber-first	Q - Science
author	Fiorella D’Onofrio
spellingShingle	Fiorella D’Onofrio misc QH573-671 misc primary sclerosing cholangitis misc aryl hydrocarbon receptor misc indole-3-carboxaldehyde misc mucosal barrier misc microbiota misc Cytology Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis
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topic_title	QH573-671 Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis primary sclerosing cholangitis aryl hydrocarbon receptor indole-3-carboxaldehyde mucosal barrier microbiota
topic	misc QH573-671 misc primary sclerosing cholangitis misc aryl hydrocarbon receptor misc indole-3-carboxaldehyde misc mucosal barrier misc microbiota misc Cytology
topic_unstemmed	misc QH573-671 misc primary sclerosing cholangitis misc aryl hydrocarbon receptor misc indole-3-carboxaldehyde misc mucosal barrier misc microbiota misc Cytology
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title	Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis
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title_full	Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis
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author_browse	Fiorella D’Onofrio Giorgia Renga Matteo Puccetti Marilena Pariano Marina Maria Bellet Ilaria Santarelli Claudia Stincardini Paolo Mosci Maurizio Ricci Stefano Giovagnoli Claudio Costantini Luigina Romani
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title_sort	indole-3-carboxaldehyde restores gut mucosal integrity and protects from liver fibrosis in murine sclerosing cholangitis
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title_auth	Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis
abstract	Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. This study points to the therapeutic potential of 3-IAld in liver pathology.
abstractGer	Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. This study points to the therapeutic potential of 3-IAld in liver pathology.
abstract_unstemmed	Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. This study points to the therapeutic potential of 3-IAld in liver pathology.
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title_short	Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis
url	https://doi.org/10.3390/cells10071622 https://doaj.org/article/a8df52a440f549719ddba6107ac9c9bc https://www.mdpi.com/2073-4409/10/7/1622 https://doaj.org/toc/2073-4409
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up_date	2024-07-04T01:51:13.046Z
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Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. 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Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis

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