Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis

Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lacti...
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Autor*in:	Yihui Ma [verfasserIn] Jinlin Song [verfasserIn] Huthayfa N. S. Almassri [verfasserIn] Dan Zhang [verfasserIn] Ting Zhang [verfasserIn] Yuting Cheng [verfasserIn] Xiaohong Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	minocycline electrospinning sustained release periodontitis osteogenesis

Übergeordnetes Werk:	In: Drug Delivery - Taylor & Francis Group, 2017, 27(2020), 1, Seite 151-160
Übergeordnetes Werk:	volume:27 ; year:2020 ; number:1 ; pages:151-160

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/10717544.2019.1709921

Katalog-ID:	DOAJ057508615

Internformat


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allfields	10.1080/10717544.2019.1709921 doi (DE-627)DOAJ057508615 (DE-599)DOAJe57ddf309c1342fd8ea2a303b989fef9 DE-627 ger DE-627 rakwb eng RM1-950 Yihui Ma verfasserin aut Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis. minocycline electrospinning sustained release periodontitis osteogenesis Therapeutics. Pharmacology Jinlin Song verfasserin aut Huthayfa N. S. Almassri verfasserin aut Dan Zhang verfasserin aut Ting Zhang verfasserin aut Yuting Cheng verfasserin aut Xiaohong Wu verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 151-160 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:151-160 https://doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/article/e57ddf309c1342fd8ea2a303b989fef9 kostenfrei http://dx.doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 151-160
spelling	10.1080/10717544.2019.1709921 doi (DE-627)DOAJ057508615 (DE-599)DOAJe57ddf309c1342fd8ea2a303b989fef9 DE-627 ger DE-627 rakwb eng RM1-950 Yihui Ma verfasserin aut Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis. minocycline electrospinning sustained release periodontitis osteogenesis Therapeutics. Pharmacology Jinlin Song verfasserin aut Huthayfa N. S. Almassri verfasserin aut Dan Zhang verfasserin aut Ting Zhang verfasserin aut Yuting Cheng verfasserin aut Xiaohong Wu verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 151-160 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:151-160 https://doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/article/e57ddf309c1342fd8ea2a303b989fef9 kostenfrei http://dx.doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 151-160
allfields_unstemmed	10.1080/10717544.2019.1709921 doi (DE-627)DOAJ057508615 (DE-599)DOAJe57ddf309c1342fd8ea2a303b989fef9 DE-627 ger DE-627 rakwb eng RM1-950 Yihui Ma verfasserin aut Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis. minocycline electrospinning sustained release periodontitis osteogenesis Therapeutics. Pharmacology Jinlin Song verfasserin aut Huthayfa N. S. Almassri verfasserin aut Dan Zhang verfasserin aut Ting Zhang verfasserin aut Yuting Cheng verfasserin aut Xiaohong Wu verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 151-160 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:151-160 https://doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/article/e57ddf309c1342fd8ea2a303b989fef9 kostenfrei http://dx.doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 151-160
allfieldsGer	10.1080/10717544.2019.1709921 doi (DE-627)DOAJ057508615 (DE-599)DOAJe57ddf309c1342fd8ea2a303b989fef9 DE-627 ger DE-627 rakwb eng RM1-950 Yihui Ma verfasserin aut Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis. minocycline electrospinning sustained release periodontitis osteogenesis Therapeutics. Pharmacology Jinlin Song verfasserin aut Huthayfa N. S. Almassri verfasserin aut Dan Zhang verfasserin aut Ting Zhang verfasserin aut Yuting Cheng verfasserin aut Xiaohong Wu verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 151-160 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:151-160 https://doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/article/e57ddf309c1342fd8ea2a303b989fef9 kostenfrei http://dx.doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 151-160
allfieldsSound	10.1080/10717544.2019.1709921 doi (DE-627)DOAJ057508615 (DE-599)DOAJe57ddf309c1342fd8ea2a303b989fef9 DE-627 ger DE-627 rakwb eng RM1-950 Yihui Ma verfasserin aut Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis. minocycline electrospinning sustained release periodontitis osteogenesis Therapeutics. Pharmacology Jinlin Song verfasserin aut Huthayfa N. S. Almassri verfasserin aut Dan Zhang verfasserin aut Ting Zhang verfasserin aut Yuting Cheng verfasserin aut Xiaohong Wu verfasserin aut In Drug Delivery Taylor & Francis Group, 2017 27(2020), 1, Seite 151-160 (DE-627)320604675 (DE-600)2020593-4 15210464 nnns volume:27 year:2020 number:1 pages:151-160 https://doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/article/e57ddf309c1342fd8ea2a303b989fef9 kostenfrei http://dx.doi.org/10.1080/10717544.2019.1709921 kostenfrei https://doaj.org/toc/1071-7544 Journal toc kostenfrei https://doaj.org/toc/1521-0464 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2020 1 151-160
language	English
source	In Drug Delivery 27(2020), 1, Seite 151-160 volume:27 year:2020 number:1 pages:151-160
sourceStr	In Drug Delivery 27(2020), 1, Seite 151-160 volume:27 year:2020 number:1 pages:151-160
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	minocycline electrospinning sustained release periodontitis osteogenesis Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Drug Delivery
authorswithroles_txt_mv	Yihui Ma @@aut@@ Jinlin Song @@aut@@ Huthayfa N. S. Almassri @@aut@@ Dan Zhang @@aut@@ Ting Zhang @@aut@@ Yuting Cheng @@aut@@ Xiaohong Wu @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	320604675
id	DOAJ057508615
language_de	englisch
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callnumber-first	R - Medicine
author	Yihui Ma
spellingShingle	Yihui Ma misc RM1-950 misc minocycline misc electrospinning misc sustained release misc periodontitis misc osteogenesis misc Therapeutics. Pharmacology Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
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topic_title	RM1-950 Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis minocycline electrospinning sustained release periodontitis osteogenesis
topic	misc RM1-950 misc minocycline misc electrospinning misc sustained release misc periodontitis misc osteogenesis misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc minocycline misc electrospinning misc sustained release misc periodontitis misc osteogenesis misc Therapeutics. Pharmacology
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title	Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
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title_full	Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
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author_browse	Yihui Ma Jinlin Song Huthayfa N. S. Almassri Dan Zhang Ting Zhang Yuting Cheng Xiaohong Wu
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title_sort	minocycline-loaded plga electrospun membrane prevents alveolar bone loss in experimental peridontitis
callnumber	RM1-950
title_auth	Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
abstract	Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis.
abstractGer	Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis.
abstract_unstemmed	Minocycline (MINO) is a tetracycline antibiotic effective against most of the bacteria microorganisms related to periodontal disease. Additionally, MINO promotes bone in vitro and in vivo. The objective of the present study was to establish the protocol for the preparation of MINO-loaded poly (lactic-co-glycolic acid) (MINO-PLGA) electrospun membranes and to evaluate their effect on osteogenesis in vitro and in a rat model of periodontitis. The characterization of MINO-PLGA electrospun membranes was assessed by scanning electron microscopy, laser scanning confocal microscopy, and contact angle measurement. The drug release study showed a sustained diffusion of MINO from electrospun membranes over a period of 40 d. The MINO-PLGA membranes containing 2% of the drug exhibited better support of osteoblast proliferation and adhesion and was subsequently used in vivo in an experimental periodontitis model. Its therapeutic potential was evaluated by the measurement of alveolar bone loss (ABL), bone volume analysis, histological analysis, and immunohistochemistry. MINO-PLGA membrane increased alveolar crest height in the periodontitis model, inhibited the expression of the ligand of the receptor activator for nuclear factor-κB (RANKL), and promoted the expression of its inhibitor, osteoprotegerin. The study demonstrated that MINO-PLGA electrospun membranes may be applied to stimulate bone regeneration in periodontitis.
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title_short	Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
url	https://doi.org/10.1080/10717544.2019.1709921 https://doaj.org/article/e57ddf309c1342fd8ea2a303b989fef9 http://dx.doi.org/10.1080/10717544.2019.1709921 https://doaj.org/toc/1071-7544 https://doaj.org/toc/1521-0464
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Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis

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