Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity

Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null fat cells to that in cells reconstituted for cav...
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Autor*in:	Tova Meshulam [verfasserIn] Michael R. Breen [verfasserIn] Libin Liu [verfasserIn] Robert G. Parton [verfasserIn] Paul F. Pilch [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	caveolin-1 cavin fasting lipid rafts lipolysis

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 52(2011), 8, Seite 1526-1532
Übergeordnetes Werk:	volume:52 ; year:2011 ; number:8 ; pages:1526-1532

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M015628

Katalog-ID:	DOAJ057532737

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source	In Journal of Lipid Research 52(2011), 8, Seite 1526-1532 volume:52 year:2011 number:8 pages:1526-1532
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authorswithroles_txt_mv	Tova Meshulam @@aut@@ Michael R. Breen @@aut@@ Libin Liu @@aut@@ Robert G. Parton @@aut@@ Paul F. Pilch @@aut@@
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author	Tova Meshulam
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topic_title	QD415-436 Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity caveolin-1 cavin fasting lipid rafts lipolysis
topic	misc QD415-436 misc caveolin-1 misc cavin misc fasting misc lipid rafts misc lipolysis misc Biochemistry
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title	Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity
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title_full	Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity
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title_sort	caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity
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title_auth	Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity
abstract	Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null fat cells to that in cells reconstituted for caveolae by caveolin-1 re-expression. We find that the Cav1-null cells have a modestly enhanced rate of lipolysis and reduced cellular integrity compared with reconstituted cells as determined by the release of lipid metabolites and lactic dehydrogenase, respectively, into the media. There are no apparent differences in the levels of lipolytic enzymes or hormonally stimulated phosphorylation events in the two cell lines. In addition, acute fasting, which dramatically raises circulating fatty acid levels in vivo, causes a significant upregulation of caveolar protein constituents. These results are consistent with the hypothesis that caveolae protect fat cells from the lipotoxic effects of elevated levels fatty acids, which are weak detergents at physiological pH, by virtue of the property of caveolae to form detergent-resistant membrane domains.
abstractGer	Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null fat cells to that in cells reconstituted for caveolae by caveolin-1 re-expression. We find that the Cav1-null cells have a modestly enhanced rate of lipolysis and reduced cellular integrity compared with reconstituted cells as determined by the release of lipid metabolites and lactic dehydrogenase, respectively, into the media. There are no apparent differences in the levels of lipolytic enzymes or hormonally stimulated phosphorylation events in the two cell lines. In addition, acute fasting, which dramatically raises circulating fatty acid levels in vivo, causes a significant upregulation of caveolar protein constituents. These results are consistent with the hypothesis that caveolae protect fat cells from the lipotoxic effects of elevated levels fatty acids, which are weak detergents at physiological pH, by virtue of the property of caveolae to form detergent-resistant membrane domains.
abstract_unstemmed	Mice and humans lacking functional caveolae are dyslipidemic and have reduced fat stores and smaller fat cells. To test the role of caveolins/caveolae in maintaining lipid stores and adipocyte integrity, we compared lipolysis in caveolin-1 (Cav1)-null fat cells to that in cells reconstituted for caveolae by caveolin-1 re-expression. We find that the Cav1-null cells have a modestly enhanced rate of lipolysis and reduced cellular integrity compared with reconstituted cells as determined by the release of lipid metabolites and lactic dehydrogenase, respectively, into the media. There are no apparent differences in the levels of lipolytic enzymes or hormonally stimulated phosphorylation events in the two cell lines. In addition, acute fasting, which dramatically raises circulating fatty acid levels in vivo, causes a significant upregulation of caveolar protein constituents. These results are consistent with the hypothesis that caveolae protect fat cells from the lipotoxic effects of elevated levels fatty acids, which are weak detergents at physiological pH, by virtue of the property of caveolae to form detergent-resistant membrane domains.
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title_short	Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity
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