Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective

Lactate, a metabolite produced when the glycolytic flux exceeds mitochondrial oxidative capacities, is now viewed as a critical regulator of metabolism by acting as both a carbon and electron carrier and a signaling molecule between cells and tissues. In recent years, increasing evidence report its...
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Gespeichert in:

Autor*in:	Damien Lagarde [verfasserIn] Yannick Jeanson [verfasserIn] Jean-Charles Portais [verfasserIn] Anne Galinier [verfasserIn] Isabelle Ader [verfasserIn] Louis Casteilla [verfasserIn] Audrey Carrière [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	lactate redox metabolism white adipocytes beige adipocytes brown adipocytes adipose tissues

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2021.689747

Katalog-ID:	DOAJ057565414

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language	English
source	In Frontiers in Physiology 12(2021) volume:12 year:2021
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topic_facet	lactate redox metabolism white adipocytes beige adipocytes brown adipocytes adipose tissues Physiology
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container_title	Frontiers in Physiology
authorswithroles_txt_mv	Damien Lagarde @@aut@@ Yannick Jeanson @@aut@@ Jean-Charles Portais @@aut@@ Anne Galinier @@aut@@ Isabelle Ader @@aut@@ Louis Casteilla @@aut@@ Audrey Carrière @@aut@@
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spellingShingle	Damien Lagarde misc QP1-981 misc lactate misc redox metabolism misc white adipocytes misc beige adipocytes misc brown adipocytes misc adipose tissues misc Physiology Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective
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topic_title	QP1-981 Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective lactate redox metabolism white adipocytes beige adipocytes brown adipocytes adipose tissues
topic	misc QP1-981 misc lactate misc redox metabolism misc white adipocytes misc beige adipocytes misc brown adipocytes misc adipose tissues misc Physiology
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title	Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective
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title_sort	lactate fluxes and plasticity of adipose tissues: a redox perspective
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title_auth	Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective
abstract	Lactate, a metabolite produced when the glycolytic flux exceeds mitochondrial oxidative capacities, is now viewed as a critical regulator of metabolism by acting as both a carbon and electron carrier and a signaling molecule between cells and tissues. In recent years, increasing evidence report its key role in white, beige, and brown adipose tissue biology, and highlights new mechanisms by which lactate participates in the maintenance of whole-body energy homeostasis. Lactate displays a wide range of biological effects in adipose cells not only through its binding to the membrane receptor but also through its transport and the subsequent effect on intracellular metabolism notably on redox balance. This study explores how lactate regulates adipocyte metabolism and plasticity by balancing intracellular redox state and by regulating specific signaling pathways. We also emphasized the contribution of adipose tissues to the regulation of systemic lactate metabolism, their roles in redox homeostasis, and related putative physiopathological repercussions associated with their decline in metabolic diseases and aging.
abstractGer	Lactate, a metabolite produced when the glycolytic flux exceeds mitochondrial oxidative capacities, is now viewed as a critical regulator of metabolism by acting as both a carbon and electron carrier and a signaling molecule between cells and tissues. In recent years, increasing evidence report its key role in white, beige, and brown adipose tissue biology, and highlights new mechanisms by which lactate participates in the maintenance of whole-body energy homeostasis. Lactate displays a wide range of biological effects in adipose cells not only through its binding to the membrane receptor but also through its transport and the subsequent effect on intracellular metabolism notably on redox balance. This study explores how lactate regulates adipocyte metabolism and plasticity by balancing intracellular redox state and by regulating specific signaling pathways. We also emphasized the contribution of adipose tissues to the regulation of systemic lactate metabolism, their roles in redox homeostasis, and related putative physiopathological repercussions associated with their decline in metabolic diseases and aging.
abstract_unstemmed	Lactate, a metabolite produced when the glycolytic flux exceeds mitochondrial oxidative capacities, is now viewed as a critical regulator of metabolism by acting as both a carbon and electron carrier and a signaling molecule between cells and tissues. In recent years, increasing evidence report its key role in white, beige, and brown adipose tissue biology, and highlights new mechanisms by which lactate participates in the maintenance of whole-body energy homeostasis. Lactate displays a wide range of biological effects in adipose cells not only through its binding to the membrane receptor but also through its transport and the subsequent effect on intracellular metabolism notably on redox balance. This study explores how lactate regulates adipocyte metabolism and plasticity by balancing intracellular redox state and by regulating specific signaling pathways. We also emphasized the contribution of adipose tissues to the regulation of systemic lactate metabolism, their roles in redox homeostasis, and related putative physiopathological repercussions associated with their decline in metabolic diseases and aging.
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title_short	Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective
url	https://doi.org/10.3389/fphys.2021.689747 https://doaj.org/article/3c711dc30eab4a7b8c53f11395a88199 https://www.frontiersin.org/articles/10.3389/fphys.2021.689747/full https://doaj.org/toc/1664-042X
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