Safety of hydroxyanthracene derivatives for use in food
Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene deriva...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) [verfasserIn] Maged Younes [verfasserIn] Peter Aggett [verfasserIn] Fernando Aguilar [verfasserIn] Riccardo Crebelli [verfasserIn] Metka Filipič [verfasserIn] Maria Jose Frutos [verfasserIn] Pierre Galtier [verfasserIn] David Gott [verfasserIn] Ursula Gundert‐Remy [verfasserIn] Gunter Georg Kuhnle [verfasserIn] Claude Lambré [verfasserIn] Jean‐Charles Leblanc [verfasserIn] Inger Therese Lillegaard [verfasserIn] Peter Moldeus [verfasserIn] Alicja Mortensen [verfasserIn] Agneta Oskarsson [verfasserIn] Ivan Stankovic [verfasserIn] Ine Waalkens‐Berendsen [verfasserIn] Rudolf Antonius Woutersen [verfasserIn] Raul J Andrade [verfasserIn] Cristina Fortes [verfasserIn] Pasquale Mosesso [verfasserIn] Patrizia Restani [verfasserIn] Fabiola Pizzo [verfasserIn] Camilla Smeraldi [verfasserIn] Adamantia Papaioannou [verfasserIn] Matthew Wright [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: EFSA Journal - Wiley, 2018, 16(2018), 1, Seite n/a-n/a |
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| Übergeordnetes Werk: |
volume:16 ; year:2018 ; number:1 ; pages:n/a-n/a |
| Links: |
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| DOI / URN: |
10.2903/j.efsa.2018.5090 |
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| Katalog-ID: |
DOAJ057692521 |
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| 520 | |a Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. | ||
| 650 | 4 | |a hydroxyanthracene derivatives | |
| 650 | 4 | |a food supplements | |
| 650 | 4 | |a genotoxicity | |
| 650 | 4 | |a carcinogenicity | |
| 650 | 4 | |a bowel function | |
| 650 | 4 | |a colorectal cancer | |
| 653 | 0 | |a Nutrition. Foods and food supply | |
| 653 | 0 | |a Chemical technology | |
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| 700 | 0 | |a Ursula Gundert‐Remy |e verfasserin |4 aut | |
| 700 | 0 | |a Gunter Georg Kuhnle |e verfasserin |4 aut | |
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10.2903/j.efsa.2018.5090 doi (DE-627)DOAJ057692521 (DE-599)DOAJ155fbde922ba454db5195dba59e8de70 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) verfasserin aut Safety of hydroxyanthracene derivatives for use in food 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. hydroxyanthracene derivatives food supplements genotoxicity carcinogenicity bowel function colorectal cancer Nutrition. Foods and food supply Chemical technology Maged Younes verfasserin aut Peter Aggett verfasserin aut Fernando Aguilar verfasserin aut Riccardo Crebelli verfasserin aut Metka Filipič verfasserin aut Maria Jose Frutos verfasserin aut Pierre Galtier verfasserin aut David Gott verfasserin aut Ursula Gundert‐Remy verfasserin aut Gunter Georg Kuhnle verfasserin aut Claude Lambré verfasserin aut Jean‐Charles Leblanc verfasserin aut Inger Therese Lillegaard verfasserin aut Peter Moldeus verfasserin aut Alicja Mortensen verfasserin aut Agneta Oskarsson verfasserin aut Ivan Stankovic verfasserin aut Ine Waalkens‐Berendsen verfasserin aut Rudolf Antonius Woutersen verfasserin aut Raul J Andrade verfasserin aut Cristina Fortes verfasserin aut Pasquale Mosesso verfasserin aut Patrizia Restani verfasserin aut Fabiola Pizzo verfasserin aut Camilla Smeraldi verfasserin aut Adamantia Papaioannou verfasserin aut Matthew Wright verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 1, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:1 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/article/155fbde922ba454db5195dba59e8de70 kostenfrei https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 1 n/a-n/a |
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10.2903/j.efsa.2018.5090 doi (DE-627)DOAJ057692521 (DE-599)DOAJ155fbde922ba454db5195dba59e8de70 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) verfasserin aut Safety of hydroxyanthracene derivatives for use in food 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. hydroxyanthracene derivatives food supplements genotoxicity carcinogenicity bowel function colorectal cancer Nutrition. Foods and food supply Chemical technology Maged Younes verfasserin aut Peter Aggett verfasserin aut Fernando Aguilar verfasserin aut Riccardo Crebelli verfasserin aut Metka Filipič verfasserin aut Maria Jose Frutos verfasserin aut Pierre Galtier verfasserin aut David Gott verfasserin aut Ursula Gundert‐Remy verfasserin aut Gunter Georg Kuhnle verfasserin aut Claude Lambré verfasserin aut Jean‐Charles Leblanc verfasserin aut Inger Therese Lillegaard verfasserin aut Peter Moldeus verfasserin aut Alicja Mortensen verfasserin aut Agneta Oskarsson verfasserin aut Ivan Stankovic verfasserin aut Ine Waalkens‐Berendsen verfasserin aut Rudolf Antonius Woutersen verfasserin aut Raul J Andrade verfasserin aut Cristina Fortes verfasserin aut Pasquale Mosesso verfasserin aut Patrizia Restani verfasserin aut Fabiola Pizzo verfasserin aut Camilla Smeraldi verfasserin aut Adamantia Papaioannou verfasserin aut Matthew Wright verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 1, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:1 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/article/155fbde922ba454db5195dba59e8de70 kostenfrei https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 1 n/a-n/a |
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10.2903/j.efsa.2018.5090 doi (DE-627)DOAJ057692521 (DE-599)DOAJ155fbde922ba454db5195dba59e8de70 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) verfasserin aut Safety of hydroxyanthracene derivatives for use in food 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. hydroxyanthracene derivatives food supplements genotoxicity carcinogenicity bowel function colorectal cancer Nutrition. Foods and food supply Chemical technology Maged Younes verfasserin aut Peter Aggett verfasserin aut Fernando Aguilar verfasserin aut Riccardo Crebelli verfasserin aut Metka Filipič verfasserin aut Maria Jose Frutos verfasserin aut Pierre Galtier verfasserin aut David Gott verfasserin aut Ursula Gundert‐Remy verfasserin aut Gunter Georg Kuhnle verfasserin aut Claude Lambré verfasserin aut Jean‐Charles Leblanc verfasserin aut Inger Therese Lillegaard verfasserin aut Peter Moldeus verfasserin aut Alicja Mortensen verfasserin aut Agneta Oskarsson verfasserin aut Ivan Stankovic verfasserin aut Ine Waalkens‐Berendsen verfasserin aut Rudolf Antonius Woutersen verfasserin aut Raul J Andrade verfasserin aut Cristina Fortes verfasserin aut Pasquale Mosesso verfasserin aut Patrizia Restani verfasserin aut Fabiola Pizzo verfasserin aut Camilla Smeraldi verfasserin aut Adamantia Papaioannou verfasserin aut Matthew Wright verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 1, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:1 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/article/155fbde922ba454db5195dba59e8de70 kostenfrei https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 1 n/a-n/a |
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10.2903/j.efsa.2018.5090 doi (DE-627)DOAJ057692521 (DE-599)DOAJ155fbde922ba454db5195dba59e8de70 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) verfasserin aut Safety of hydroxyanthracene derivatives for use in food 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. hydroxyanthracene derivatives food supplements genotoxicity carcinogenicity bowel function colorectal cancer Nutrition. Foods and food supply Chemical technology Maged Younes verfasserin aut Peter Aggett verfasserin aut Fernando Aguilar verfasserin aut Riccardo Crebelli verfasserin aut Metka Filipič verfasserin aut Maria Jose Frutos verfasserin aut Pierre Galtier verfasserin aut David Gott verfasserin aut Ursula Gundert‐Remy verfasserin aut Gunter Georg Kuhnle verfasserin aut Claude Lambré verfasserin aut Jean‐Charles Leblanc verfasserin aut Inger Therese Lillegaard verfasserin aut Peter Moldeus verfasserin aut Alicja Mortensen verfasserin aut Agneta Oskarsson verfasserin aut Ivan Stankovic verfasserin aut Ine Waalkens‐Berendsen verfasserin aut Rudolf Antonius Woutersen verfasserin aut Raul J Andrade verfasserin aut Cristina Fortes verfasserin aut Pasquale Mosesso verfasserin aut Patrizia Restani verfasserin aut Fabiola Pizzo verfasserin aut Camilla Smeraldi verfasserin aut Adamantia Papaioannou verfasserin aut Matthew Wright verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 1, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:1 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/article/155fbde922ba454db5195dba59e8de70 kostenfrei https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 1 n/a-n/a |
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10.2903/j.efsa.2018.5090 doi (DE-627)DOAJ057692521 (DE-599)DOAJ155fbde922ba454db5195dba59e8de70 DE-627 ger DE-627 rakwb eng TX341-641 TP1-1185 EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) verfasserin aut Safety of hydroxyanthracene derivatives for use in food 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. hydroxyanthracene derivatives food supplements genotoxicity carcinogenicity bowel function colorectal cancer Nutrition. Foods and food supply Chemical technology Maged Younes verfasserin aut Peter Aggett verfasserin aut Fernando Aguilar verfasserin aut Riccardo Crebelli verfasserin aut Metka Filipič verfasserin aut Maria Jose Frutos verfasserin aut Pierre Galtier verfasserin aut David Gott verfasserin aut Ursula Gundert‐Remy verfasserin aut Gunter Georg Kuhnle verfasserin aut Claude Lambré verfasserin aut Jean‐Charles Leblanc verfasserin aut Inger Therese Lillegaard verfasserin aut Peter Moldeus verfasserin aut Alicja Mortensen verfasserin aut Agneta Oskarsson verfasserin aut Ivan Stankovic verfasserin aut Ine Waalkens‐Berendsen verfasserin aut Rudolf Antonius Woutersen verfasserin aut Raul J Andrade verfasserin aut Cristina Fortes verfasserin aut Pasquale Mosesso verfasserin aut Patrizia Restani verfasserin aut Fabiola Pizzo verfasserin aut Camilla Smeraldi verfasserin aut Adamantia Papaioannou verfasserin aut Matthew Wright verfasserin aut In EFSA Journal Wiley, 2018 16(2018), 1, Seite n/a-n/a (DE-627)618834982 (DE-600)2540248-1 18314732 nnns volume:16 year:2018 number:1 pages:n/a-n/a https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/article/155fbde922ba454db5195dba59e8de70 kostenfrei https://doi.org/10.2903/j.efsa.2018.5090 kostenfrei https://doaj.org/toc/1831-4732 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2018 1 n/a-n/a |
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EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) @@aut@@ Maged Younes @@aut@@ Peter Aggett @@aut@@ Fernando Aguilar @@aut@@ Riccardo Crebelli @@aut@@ Metka Filipič @@aut@@ Maria Jose Frutos @@aut@@ Pierre Galtier @@aut@@ David Gott @@aut@@ Ursula Gundert‐Remy @@aut@@ Gunter Georg Kuhnle @@aut@@ Claude Lambré @@aut@@ Jean‐Charles Leblanc @@aut@@ Inger Therese Lillegaard @@aut@@ Peter Moldeus @@aut@@ Alicja Mortensen @@aut@@ Agneta Oskarsson @@aut@@ Ivan Stankovic @@aut@@ Ine Waalkens‐Berendsen @@aut@@ Rudolf Antonius Woutersen @@aut@@ Raul J Andrade @@aut@@ Cristina Fortes @@aut@@ Pasquale Mosesso @@aut@@ Patrizia Restani @@aut@@ Fabiola Pizzo @@aut@@ Camilla Smeraldi @@aut@@ Adamantia Papaioannou @@aut@@ Matthew Wright @@aut@@ |
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Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. 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EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) |
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safety of hydroxyanthracene derivatives for use in food |
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Safety of hydroxyanthracene derivatives for use in food |
| abstract |
Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. |
| abstractGer |
Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. |
| abstract_unstemmed |
Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene derivatives are a class of chemical substances naturally occurring in different botanical species and used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic effects. On the basis of the data currently available, the Panel noted that emodin, aloe‐emodin and the structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene derivatives in the extract. Furthermore, aloe‐emodin was shown to be genotoxic in vivo and the whole‐leaf aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe‐emodin and emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives that does not give rise to concerns about harmful effects to health. |
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Safety of hydroxyanthracene derivatives for use in food |
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Maged Younes Peter Aggett Fernando Aguilar Riccardo Crebelli Metka Filipič Maria Jose Frutos Pierre Galtier David Gott Ursula Gundert‐Remy Gunter Georg Kuhnle Claude Lambré Jean‐Charles Leblanc Inger Therese Lillegaard Peter Moldeus Alicja Mortensen Agneta Oskarsson Ivan Stankovic Ine Waalkens‐Berendsen Rudolf Antonius Woutersen Raul J Andrade Cristina Fortes Pasquale Mosesso Patrizia Restani Fabiola Pizzo Camilla Smeraldi Adamantia Papaioannou Matthew Wright |
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Maged Younes Peter Aggett Fernando Aguilar Riccardo Crebelli Metka Filipič Maria Jose Frutos Pierre Galtier David Gott Ursula Gundert‐Remy Gunter Georg Kuhnle Claude Lambré Jean‐Charles Leblanc Inger Therese Lillegaard Peter Moldeus Alicja Mortensen Agneta Oskarsson Ivan Stankovic Ine Waalkens‐Berendsen Rudolf Antonius Woutersen Raul J Andrade Cristina Fortes Pasquale Mosesso Patrizia Restani Fabiola Pizzo Camilla Smeraldi Adamantia Papaioannou Matthew Wright |
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| score |
7.3993816 |